用于抗肿瘤药物递送的刺激敏感型聚合物载体的研究进展

刺激敏感型聚合物纳米载体由于在药物递送和药物的智能控释方面具有良好的应用前景,受到了广大研究人员的广泛关注。其种类包括响应内源刺激的pH敏感聚合物载体、氧化还原敏感聚合物载体和低氧敏感聚合物载体,响应外源刺激的光敏感聚合物载体和超声波敏感聚合物载体。本文主要综述不同刺激敏感型聚合物载体和多重刺激响应聚合物载体的研究进展,激励未来的研究人员设计和合成新型刺激响应聚合物载体,以便实现更加高效的药物递送和智能控释的效果。

Study on Shock Wave and Turbulent Boundary Layer Interactions in a Square Duct at Mach 2 and 4

In this paper, the outline of the Mach 4 supersonic wind tunnel for the investigation of the supersonic internal flows in ducts was firstly described. Secondly, the location, structure and characteristics of the Mach 2 and Mach 4 pseudo-shock waves in a square duct were investigated by color schlieren photographs and duct wall pressure fluctuation measurements. Finally, the wall shear stress distributions on the side, top and bottom walls of the square duct with the Mach 4 pseudo-shock wave were investigated qualitatively by the shear stress-sensitive liquid crystal visualization method. The side wall boundary layer separation region under the first shock is narrow near the top wall, while the side wall boundary layer separation region under the first shock is very wide near the bottom wall.