To determine whether the short or long protocol for controlled ovarian hyperstimulation works better in older patients undergoing IVF. Design: Controlled, randomized study. Setting: A single private IVF center. Patien...To determine whether the short or long protocol for controlled ovarian hyperstimulation works better in older patients undergoing IVF. Design: Controlled, randomized study. Setting: A single private IVF center. Patient(s): Two hundred twenty infertile women aged ≥ 40 years undergoing IVF.Intervention(s): At their first IVF cycle, the women were randomized into two stud groups according to a computer-generated number sequence: 110 patients were treated with a long protocol, and the other 110 were treated with a short protocol for controlled ovarian hyperstimulation. Main Outcome Measure(s): Days of stimulation, E2 level at the day of hCG administration, amount of FSH administered, number of oocytes collected, number of embryos obtained, pregnancy rate, implantation rate. Result(s): Patients treated with a long protocol showed a significantly higher number of oocytes retrieved, a higher number of embryos obtained, and a higher pregnancy rate, both for cycle and transfer, compared with the short-protocol patients. The other parameters evaluated did not show any statistically significant differences. Conclusion(s): Our study showed that the long protocol performed better than the short protocol in older women. Our findings demonstrated that flare-up in older women might be detrimental.展开更多
枸椽酸克罗米芬(clomip hene cierocee 简称C)又称氯底酚胺或舒经芬．是三苯乙烯的衍生物，它有顺式或反式。顺式CC具有雌激素作用，反式CC则有抗雌激素作用．伴较弱的雌性激素性质．是合成的非类固醇物质，结构与乙烯雌酚相似．每片50m...枸椽酸克罗米芬(clomip hene cierocee 简称C)又称氯底酚胺或舒经芬．是三苯乙烯的衍生物，它有顺式或反式。顺式CC具有雌激素作用，反式CC则有抗雌激素作用．伴较弱的雌性激素性质．是合成的非类固醇物质，结构与乙烯雌酚相似．每片50mg。口服后当下丘脑的雌二醇受体结合而启动生理的排卵周期变化。展开更多
文摘To determine whether the short or long protocol for controlled ovarian hyperstimulation works better in older patients undergoing IVF. Design: Controlled, randomized study. Setting: A single private IVF center. Patient(s): Two hundred twenty infertile women aged ≥ 40 years undergoing IVF.Intervention(s): At their first IVF cycle, the women were randomized into two stud groups according to a computer-generated number sequence: 110 patients were treated with a long protocol, and the other 110 were treated with a short protocol for controlled ovarian hyperstimulation. Main Outcome Measure(s): Days of stimulation, E2 level at the day of hCG administration, amount of FSH administered, number of oocytes collected, number of embryos obtained, pregnancy rate, implantation rate. Result(s): Patients treated with a long protocol showed a significantly higher number of oocytes retrieved, a higher number of embryos obtained, and a higher pregnancy rate, both for cycle and transfer, compared with the short-protocol patients. The other parameters evaluated did not show any statistically significant differences. Conclusion(s): Our study showed that the long protocol performed better than the short protocol in older women. Our findings demonstrated that flare-up in older women might be detrimental.
文摘枸椽酸克罗米芬(clomip hene cierocee 简称C)又称氯底酚胺或舒经芬．是三苯乙烯的衍生物，它有顺式或反式。顺式CC具有雌激素作用，反式CC则有抗雌激素作用．伴较弱的雌性激素性质．是合成的非类固醇物质，结构与乙烯雌酚相似．每片50mg。口服后当下丘脑的雌二醇受体结合而启动生理的排卵周期变化。
