[Objective] Water quality variation trend of Wei River was analyzed and the water quality evaluation was performed in this study. [Method] Stationing and water sampling were conducted along Wei River at three differen...[Objective] Water quality variation trend of Wei River was analyzed and the water quality evaluation was performed in this study. [Method] Stationing and water sampling were conducted along Wei River at three different sites during the 12 months from January to December of 2014, the water samples were pre-treated and analyzed on chemical pollution indexes with the national standard, water quality data of Wei River in the 12 months was processed with periodic time series method, Spearman rank correlation coefficient was adopted to test pollution changing trend, and water quality status of Wei water was evaluated with integrated index of organic pollution. [Result] NH3-N and TN of Wei River exceeded the standard's lim- its; [ Y~ [ 〉Wp=0.506, [ Yss~ [ 〉Wp=0.506 and [ Y&=0~,, Diecqieo 〉Wp=0.506 indicated that the integrated index of organic pollution of Shawangdu section, S.huyuan section and Tongguan Diaoqiao section showed a significant downtrend, respetively; and the water quality of the three sections became better, and it was worth noting that it was necessary to strengthen the water quality control of Wei River from January to June, so as to ensure that the water quality of Wei River reached the standard all the time. [Cendasien] This research was of significance in improving water ecological environment in Weinan as well as rationally utilizing water resources and finally realizing permanent development. Key words Wei River; Water quality variation trend; Integrated index of organic pollution; Evaluation展开更多
The output of 25 models used in the Coupled Model Intercomparison Project phase 3 (CMIP3) were evaluated,with a focus on summer precipitation in eastern China for the last 40 years of the 20th century.Most mod-els fai...The output of 25 models used in the Coupled Model Intercomparison Project phase 3 (CMIP3) were evaluated,with a focus on summer precipitation in eastern China for the last 40 years of the 20th century.Most mod-els failed to reproduce rainfall associated with the East Asian summer monsoon (EASM),and hence the seasonal cycle in eastern China,but provided reasonable results in Southwest (SW) and Northeast China (NE).The simula-tions produced reasonable results for the Yangtze-Huai (YH) Basin area,although the Meiyu phenomenon was underestimated in general.One typical regional phe-nomenon,a seasonal northward shift in the rain belt from early to late summer,was completely missed by most models.The long-term climate trends in rainfall over eastern China were largely underestimated,and the ob-served geographical pattern of rainfall changes was not reproduced by most models.Precipitation extremes were evaluated via parameters of fitted GEV (Generalized Ex-treme Values) distributions.The annual extremes were grossly underestimated in the monsoon-dominated YH and SW regions,but reasonable values were calculated for the North China (NC) and NE regions.These results suggest a general failure to capture the dynamics of the EASM in current coupled climate models.Nonetheless,models with higher resolution tend to reproduce larger decadal trends and annual extremes of precipitation in the regions studied.展开更多
The emergence of media convergence have so huge impact on paper-based media that paper-based media no longer has a monopoly. Some people assert that paper-based media will come to an end. However, the author believes ...The emergence of media convergence have so huge impact on paper-based media that paper-based media no longer has a monopoly. Some people assert that paper-based media will come to an end. However, the author believes that the paper media will not come to an end under the media convergence trend. It will develop parallel with media integration. The reason why the author has this view is that, on one hand, paper-based media has its unique physical characteristics. In the real world, paper media brought us the aesthetic experience by "five senses" . It cannot be replaced by the media convergence. The paper media will also make survival steering dimension; on the other hand, cultural heritage of the paper media make itself a unique appreciation of the value and not transcendent. Therefore, the paper media in the media convergence trend will continue to exist and turned to be "concept book" that admiring is the main part and reading supplemented.展开更多
Based on observations and Coupled Model lntercomparison Project Phase 5 (CMIP5) results, multidecadal variations and trends in annual mean surface air temperature anomalies (SATa) at global, hemispheric, and hemis...Based on observations and Coupled Model lntercomparison Project Phase 5 (CMIP5) results, multidecadal variations and trends in annual mean surface air temperature anomalies (SATa) at global, hemispheric, and hemispheric land and ocean scales in the past and under the future scenarios of two representative concentration pathways (RCPs) are analyzed. Fifteen models are selected based on their performances in capturing the temporal variability, long-term trend, multidecadal variations, and trends in global annual mean SATa. Observational data analysis shows that the multidecadal variations in annual mean SATa of the land and ocean in the northern hemisphere (NH) and of the ocean in the southern hemisphere (SH) are similar to those of the global mean, showing an increase during the 1900-1944 and 1971-2000 periods, and flattening or even cooling during the 1945-1970 and 2001-2013 periods. These observed characteristics are basically reproduced by the models. However, SATa over SH land show an increase during the 1945-1970 period, which differs from the other hemispheric scales, and this feature is not captured well by the models. For the recent hiatus period (2001-2013), the projected trends of BCC-CSM1-1-m, CMCC-CM, GFDL-ESM2M, and NorESM1-ME at the global and hemispheric scales are closest to the observations based on RCP4.5 and RCP8.5 scenarios, suggesting that these four models have better projection capability in SATa. Because these four models are better at simulating and projecting the multidecadal trends of SATa, they are selected to analyze future SATa variations at the global and hemispheric scales during the 2006-2099 period. The selected multi-model ensemble (MME) projected trends in annual mean SATa for the globe, NH, and SH under RCP4.5 (RCP8.5) are 0.17 (0.29) ℃, 0.22 (0.36) ℃, and 0.11 (0.23) ℃-decade-1 in the 21st century, respectively. These values are significantly lower than the projections of CMIP5 MME without model selection.展开更多
With the development of economy and society, every comer of the world' s cultural and spiritual civilization are closely linked together, At the same time, the clothing and contemporary art are in the big tide of mut...With the development of economy and society, every comer of the world' s cultural and spiritual civilization are closely linked together, At the same time, the clothing and contemporary art are in the big tide of mutual penetration and mutual influence. Contemporary art has influenced on the costume design. Costume design can play their own advantages in art tide, toward a higher point. The passage from the clothing design and other fields of contemporary art in the process of cross-border integration explores the future development trend of garment design.展开更多
Background Although thyroid hormone (TH) has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role i...Background Although thyroid hormone (TH) has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role in statin responsiveness in patients with acute myocardial infarction (AMI). Methods Consecutive 1091 hospitalized AMI patients in Fuwai hospital (Beijing, China) were enrolled into this current study. The study population was divided into three groups based on the intensity of statin treatment: low-intensity (n = 221), moderate-intensity (n = 712) and high-intensity (n = 158). Lipid levels were measured after statin therapy lasting for 10-14 days. The association between TH, lipid profile levels and achievement of low-density lipoprotein cholesterol (LDL-C) lowering goals was explored in patients with AMI on statin therapy. Results By general linear analysis, a significant linear trend between free triiodothyronine (FT3) and LDL-C level (linear coefficient r = -0.082, P = 0.001) and FT3 and total cholesterol (TC) level (r = -0.105, P = 0.031) was observed in the moderate-intensity statin group. A more apparent linear trend was detected in the high-intensity statin group (for LDL-C: r = -0.113, P = 0.005; for TC: r = -0.172, P = 0.029, respectively). However, no significant correlation was observed in the low-intensity statin group. Compared with the low-FT3 group (defined as FT3 〈 1.79 pg/mL), the OR (95% CI) for attaining a LDL-C 〈 3.0mmol/L was found to be 2.217 (1.001–4.839) in the higher FT3 group (〉 2.95 pg/mL). The OR (95% CI) for attaining the more intensive goal (LDL-C 〈 1.8mmol/L) was 2.836 (1.014–5.182). Conclusions Our study reveals that variation in FT3 levels is related to the cholesterol-lowering responsiveness of statins in AMI patients. These findings suggest that low FT3 may be a factor responsible for lack of LDL-C goal attainment and patients’ poor responsiveness to statin treatment.展开更多
Three types of low-carbon vehicle technologies in China are reviewed. Potential effects are listed for those integrated energy-saving technologies for conventional vehicles. Low carbon transitions, including alternati...Three types of low-carbon vehicle technologies in China are reviewed. Potential effects are listed for those integrated energy-saving technologies for conventional vehicles. Low carbon transitions, including alternative vehicle power train systems and fuels, are discussed on their development status and trends, including life cycle primary fossil energy use and greenhouse gas emissions of each pathway. To further support the low-carbon vehicle technologies development, integrated policies should seek to: (1) employ those integrated energy-saving technologies, (2) apply hybrid electric technology, (3) commercialize electric vehicles through battery technology innovation, (4) support fuel cell vehicles and hydrogen technology R&D for future potential applications, (5) boost the R&D of second generation biofuel technology, and (6) conduct further research on applying low-carbon technologies including CO2 capture and storage technology to coal-based transportation solutions.展开更多
Public benefit trust is of great significance to the development of social public welfare, and the cy-pres doctrine as a special principle of public benefit trust, plays an important role in protecting the continuatio...Public benefit trust is of great significance to the development of social public welfare, and the cy-pres doctrine as a special principle of public benefit trust, plays an important role in protecting the continuation of public benefit trust, and the realization and reasonable use of high-efficiency trust properties. In this paper, therefore, the origin, establishment, and development trend of the approximation principle as well as its current legislative situation in China are studied, and also its applicability of the Cy-Pres doctrine in China's public benefit trust is briefly evaluated, so as to further deepen the understanding of the Cy-Pres doctrine and develop the public benefit trust undertakings in China.展开更多
AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraduc...AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course.展开更多
Interior is the main space of human activities, which is an important part of human life and design activities, and is the link between spiritual civilization and material civilization. Interior design originates from...Interior is the main space of human activities, which is an important part of human life and design activities, and is the link between spiritual civilization and material civilization. Interior design originates from life, and needs to solve the problem of the material world and spiritual world. People improve the living environment and life quality through interior designs. The style of design depends on the geographical features and various cultures, which refi ects the artistic features and personality. The development history of modern architecture and interior design shows that the style of interior design is an important part of the whole architectural style, which reffects the design features of the whole building. Therefore, interior design and outdoor design should be in harmony. The orientation and characteristics of interior design determine the necessity of the style reforms. The future development trend of interior development may have the following characteristics humanism, green design, nationalization, intelligence and regionalization.展开更多
Objective: To observe the effect of moxibustion therapy on heme oxygenase-1(HO-1) and monocyte chemoattractant protein-3(MCP-3) protein expressions in the colonic mucosa of rats with Crohn's disease(CD), and t...Objective: To observe the effect of moxibustion therapy on heme oxygenase-1(HO-1) and monocyte chemoattractant protein-3(MCP-3) protein expressions in the colonic mucosa of rats with Crohn's disease(CD), and to explore the intestinal mucosal immune mechanism of moxibustion therapy in treating CD. Methods: The CD rat model was established using the internationally accepted Morris method. The rats were randomly divided into a model group, a herbal cake-partitioned moxibustion group, a mild moxibustion group, a cigarette moxibustion group and a hot compress group, which were compared with the normal group. Except the normal group and the model group, rats in the other groups accepted different moxibustion therapies on bilateral Tianshu(ST 25). Hematoxylin-eosin(HE) staining was conducted and the pathological changes of the colon were observed under light microscope; the expressions of HO-1 and MCP-3 protein in rat's colonic mucosa were determined by immunohisto-chemistry. Results: Compared with the normal group, rats in the model group showed mucosal defect, villus destruction or loss, submucosal congestion and edema, glandular destruction or disappearance, reduced goblet cells, ulcer formation, significantly increased positive target area and positive target integral optical density of HO-1 and MCP-3 protein expression(all P〈0.01). After treatment, compared with the model group, colonic mucosa was significantly improved in the herbal cake-partitioned moxibustion group and the mild moxibustion group, which mainly showed that the intestinal glands were arranged regularly, ulcer surfaces were covered by the neoformative epitheliums, or intestinal ulcers were replaced by the nascent granulation tissue, and submucosal edema was alleviated, with a small amount of inflammatory cell infiltration. The total areas and the integral optical densities of the positive targets for rat's colonic mucosa HO-1 and MCP-3 protein expressions were decreased(all P〈0.01). Compared with the cigarette moxibustion group and the hot compress group, the total areas and the integral optical densities of the positive targets for rat's colonic mucosa HO-1 and MCP-3 protein expressions were significantly decreased(all P〈0.01) in the herbal cake-partitioned moxibustion group and the mild moxibustion group. Conclusion: Herbal cake-partitioned moxibustion and mild moxibustion can significantly improve the inflammatory response of colonic mucosa in CD rats. It can down-regulate the expressions of HO-1 and MCP-3 proteins in the colonic mucosa of CD rats, which may be one of the mechanism in intestinal mucosal immunity caused by moxibustion therapy.展开更多
基金Supported by Natural Science Foundation of China(41171061)Technological Innovation Support Fund of Weinan city(2012KYJ-3)Characteristic Discipline Construction Project of Weinan Normal University(14TSXK04,14TSXK05)~~
文摘[Objective] Water quality variation trend of Wei River was analyzed and the water quality evaluation was performed in this study. [Method] Stationing and water sampling were conducted along Wei River at three different sites during the 12 months from January to December of 2014, the water samples were pre-treated and analyzed on chemical pollution indexes with the national standard, water quality data of Wei River in the 12 months was processed with periodic time series method, Spearman rank correlation coefficient was adopted to test pollution changing trend, and water quality status of Wei water was evaluated with integrated index of organic pollution. [Result] NH3-N and TN of Wei River exceeded the standard's lim- its; [ Y~ [ 〉Wp=0.506, [ Yss~ [ 〉Wp=0.506 and [ Y&=0~,, Diecqieo 〉Wp=0.506 indicated that the integrated index of organic pollution of Shawangdu section, S.huyuan section and Tongguan Diaoqiao section showed a significant downtrend, respetively; and the water quality of the three sections became better, and it was worth noting that it was necessary to strengthen the water quality control of Wei River from January to June, so as to ensure that the water quality of Wei River reached the standard all the time. [Cendasien] This research was of significance in improving water ecological environment in Weinan as well as rationally utilizing water resources and finally realizing permanent development. Key words Wei River; Water quality variation trend; Integrated index of organic pollution; Evaluation
基金supported by the National Basic Research Program of China 2009CB421401/2006CB400503the Chinese Meteorological Administration ProgramGYHY200706001
文摘The output of 25 models used in the Coupled Model Intercomparison Project phase 3 (CMIP3) were evaluated,with a focus on summer precipitation in eastern China for the last 40 years of the 20th century.Most mod-els failed to reproduce rainfall associated with the East Asian summer monsoon (EASM),and hence the seasonal cycle in eastern China,but provided reasonable results in Southwest (SW) and Northeast China (NE).The simula-tions produced reasonable results for the Yangtze-Huai (YH) Basin area,although the Meiyu phenomenon was underestimated in general.One typical regional phe-nomenon,a seasonal northward shift in the rain belt from early to late summer,was completely missed by most models.The long-term climate trends in rainfall over eastern China were largely underestimated,and the ob-served geographical pattern of rainfall changes was not reproduced by most models.Precipitation extremes were evaluated via parameters of fitted GEV (Generalized Ex-treme Values) distributions.The annual extremes were grossly underestimated in the monsoon-dominated YH and SW regions,but reasonable values were calculated for the North China (NC) and NE regions.These results suggest a general failure to capture the dynamics of the EASM in current coupled climate models.Nonetheless,models with higher resolution tend to reproduce larger decadal trends and annual extremes of precipitation in the regions studied.
文摘The emergence of media convergence have so huge impact on paper-based media that paper-based media no longer has a monopoly. Some people assert that paper-based media will come to an end. However, the author believes that the paper media will not come to an end under the media convergence trend. It will develop parallel with media integration. The reason why the author has this view is that, on one hand, paper-based media has its unique physical characteristics. In the real world, paper media brought us the aesthetic experience by "five senses" . It cannot be replaced by the media convergence. The paper media will also make survival steering dimension; on the other hand, cultural heritage of the paper media make itself a unique appreciation of the value and not transcendent. Therefore, the paper media in the media convergence trend will continue to exist and turned to be "concept book" that admiring is the main part and reading supplemented.
基金This study was supported by National Key Research and Development Program of China (2016YFA0601801), the State Key Program of National Natural Science Foundation of China (41530424), National Program on Global Change and Air-Sea Interactions, State Oceanic Administration (SOA) (GASI-IPOVAI-03), and the National Natural Science Foundation of China (41305121). We sincerely thank two anonymous reviewers whose comments improved the paper.
文摘Based on observations and Coupled Model lntercomparison Project Phase 5 (CMIP5) results, multidecadal variations and trends in annual mean surface air temperature anomalies (SATa) at global, hemispheric, and hemispheric land and ocean scales in the past and under the future scenarios of two representative concentration pathways (RCPs) are analyzed. Fifteen models are selected based on their performances in capturing the temporal variability, long-term trend, multidecadal variations, and trends in global annual mean SATa. Observational data analysis shows that the multidecadal variations in annual mean SATa of the land and ocean in the northern hemisphere (NH) and of the ocean in the southern hemisphere (SH) are similar to those of the global mean, showing an increase during the 1900-1944 and 1971-2000 periods, and flattening or even cooling during the 1945-1970 and 2001-2013 periods. These observed characteristics are basically reproduced by the models. However, SATa over SH land show an increase during the 1945-1970 period, which differs from the other hemispheric scales, and this feature is not captured well by the models. For the recent hiatus period (2001-2013), the projected trends of BCC-CSM1-1-m, CMCC-CM, GFDL-ESM2M, and NorESM1-ME at the global and hemispheric scales are closest to the observations based on RCP4.5 and RCP8.5 scenarios, suggesting that these four models have better projection capability in SATa. Because these four models are better at simulating and projecting the multidecadal trends of SATa, they are selected to analyze future SATa variations at the global and hemispheric scales during the 2006-2099 period. The selected multi-model ensemble (MME) projected trends in annual mean SATa for the globe, NH, and SH under RCP4.5 (RCP8.5) are 0.17 (0.29) ℃, 0.22 (0.36) ℃, and 0.11 (0.23) ℃-decade-1 in the 21st century, respectively. These values are significantly lower than the projections of CMIP5 MME without model selection.
文摘With the development of economy and society, every comer of the world' s cultural and spiritual civilization are closely linked together, At the same time, the clothing and contemporary art are in the big tide of mutual penetration and mutual influence. Contemporary art has influenced on the costume design. Costume design can play their own advantages in art tide, toward a higher point. The passage from the clothing design and other fields of contemporary art in the process of cross-border integration explores the future development trend of garment design.
基金We acknowledge the help from Wei LI, Yang WANG and Yan-Yan ZHAO (Medical Research & Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Disease, China) with the statistical analyses. This work was supported by the National Natural Science Foundation of China (No. 81470485), Capital Clinical Featured Application Research Project (No. z151100004015175), and CAMS Innovation Fund for Medical Sciences (CIFMS 2016-I2M- 1-009). The authors have no potential conflict of interest to declare.
文摘Background Although thyroid hormone (TH) has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role in statin responsiveness in patients with acute myocardial infarction (AMI). Methods Consecutive 1091 hospitalized AMI patients in Fuwai hospital (Beijing, China) were enrolled into this current study. The study population was divided into three groups based on the intensity of statin treatment: low-intensity (n = 221), moderate-intensity (n = 712) and high-intensity (n = 158). Lipid levels were measured after statin therapy lasting for 10-14 days. The association between TH, lipid profile levels and achievement of low-density lipoprotein cholesterol (LDL-C) lowering goals was explored in patients with AMI on statin therapy. Results By general linear analysis, a significant linear trend between free triiodothyronine (FT3) and LDL-C level (linear coefficient r = -0.082, P = 0.001) and FT3 and total cholesterol (TC) level (r = -0.105, P = 0.031) was observed in the moderate-intensity statin group. A more apparent linear trend was detected in the high-intensity statin group (for LDL-C: r = -0.113, P = 0.005; for TC: r = -0.172, P = 0.029, respectively). However, no significant correlation was observed in the low-intensity statin group. Compared with the low-FT3 group (defined as FT3 〈 1.79 pg/mL), the OR (95% CI) for attaining a LDL-C 〈 3.0mmol/L was found to be 2.217 (1.001–4.839) in the higher FT3 group (〉 2.95 pg/mL). The OR (95% CI) for attaining the more intensive goal (LDL-C 〈 1.8mmol/L) was 2.836 (1.014–5.182). Conclusions Our study reveals that variation in FT3 levels is related to the cholesterol-lowering responsiveness of statins in AMI patients. These findings suggest that low FT3 may be a factor responsible for lack of LDL-C goal attainment and patients’ poor responsiveness to statin treatment.
基金co-supported by the China National Social Science Foundation(09&ZD029)MOE Project of Key Research Institute of Humanities and Social Sciences at Universities in China (2009JJD790029)+1 种基金Doctoral Thesis Fund of Beijing Municipal Science and Technology Commission (zz200923)the CAERC program(Tsinghua/ GM/SAIC-China)
文摘Three types of low-carbon vehicle technologies in China are reviewed. Potential effects are listed for those integrated energy-saving technologies for conventional vehicles. Low carbon transitions, including alternative vehicle power train systems and fuels, are discussed on their development status and trends, including life cycle primary fossil energy use and greenhouse gas emissions of each pathway. To further support the low-carbon vehicle technologies development, integrated policies should seek to: (1) employ those integrated energy-saving technologies, (2) apply hybrid electric technology, (3) commercialize electric vehicles through battery technology innovation, (4) support fuel cell vehicles and hydrogen technology R&D for future potential applications, (5) boost the R&D of second generation biofuel technology, and (6) conduct further research on applying low-carbon technologies including CO2 capture and storage technology to coal-based transportation solutions.
文摘Public benefit trust is of great significance to the development of social public welfare, and the cy-pres doctrine as a special principle of public benefit trust, plays an important role in protecting the continuation of public benefit trust, and the realization and reasonable use of high-efficiency trust properties. In this paper, therefore, the origin, establishment, and development trend of the approximation principle as well as its current legislative situation in China are studied, and also its applicability of the Cy-Pres doctrine in China's public benefit trust is briefly evaluated, so as to further deepen the understanding of the Cy-Pres doctrine and develop the public benefit trust undertakings in China.
文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course.
文摘Interior is the main space of human activities, which is an important part of human life and design activities, and is the link between spiritual civilization and material civilization. Interior design originates from life, and needs to solve the problem of the material world and spiritual world. People improve the living environment and life quality through interior designs. The style of design depends on the geographical features and various cultures, which refi ects the artistic features and personality. The development history of modern architecture and interior design shows that the style of interior design is an important part of the whole architectural style, which reffects the design features of the whole building. Therefore, interior design and outdoor design should be in harmony. The orientation and characteristics of interior design determine the necessity of the style reforms. The future development trend of interior development may have the following characteristics humanism, green design, nationalization, intelligence and regionalization.
基金supported by National Basic Research Program of China(973 Program,No.2015CB554501)Shang hai Leading Academic Discipline Project(No.S30304)+2 种基金Youth Project of Anhui Provincial Natural Science Foundation(No.1508085QH160)Youth Scientific Research Fund Project of Anhui University of Chinese Medicine(No.2014qn004)Innovation Team Project of Scientific Research Platform for Universities in AnhuiProvince(No.2015TD033)~~
文摘Objective: To observe the effect of moxibustion therapy on heme oxygenase-1(HO-1) and monocyte chemoattractant protein-3(MCP-3) protein expressions in the colonic mucosa of rats with Crohn's disease(CD), and to explore the intestinal mucosal immune mechanism of moxibustion therapy in treating CD. Methods: The CD rat model was established using the internationally accepted Morris method. The rats were randomly divided into a model group, a herbal cake-partitioned moxibustion group, a mild moxibustion group, a cigarette moxibustion group and a hot compress group, which were compared with the normal group. Except the normal group and the model group, rats in the other groups accepted different moxibustion therapies on bilateral Tianshu(ST 25). Hematoxylin-eosin(HE) staining was conducted and the pathological changes of the colon were observed under light microscope; the expressions of HO-1 and MCP-3 protein in rat's colonic mucosa were determined by immunohisto-chemistry. Results: Compared with the normal group, rats in the model group showed mucosal defect, villus destruction or loss, submucosal congestion and edema, glandular destruction or disappearance, reduced goblet cells, ulcer formation, significantly increased positive target area and positive target integral optical density of HO-1 and MCP-3 protein expression(all P〈0.01). After treatment, compared with the model group, colonic mucosa was significantly improved in the herbal cake-partitioned moxibustion group and the mild moxibustion group, which mainly showed that the intestinal glands were arranged regularly, ulcer surfaces were covered by the neoformative epitheliums, or intestinal ulcers were replaced by the nascent granulation tissue, and submucosal edema was alleviated, with a small amount of inflammatory cell infiltration. The total areas and the integral optical densities of the positive targets for rat's colonic mucosa HO-1 and MCP-3 protein expressions were decreased(all P〈0.01). Compared with the cigarette moxibustion group and the hot compress group, the total areas and the integral optical densities of the positive targets for rat's colonic mucosa HO-1 and MCP-3 protein expressions were significantly decreased(all P〈0.01) in the herbal cake-partitioned moxibustion group and the mild moxibustion group. Conclusion: Herbal cake-partitioned moxibustion and mild moxibustion can significantly improve the inflammatory response of colonic mucosa in CD rats. It can down-regulate the expressions of HO-1 and MCP-3 proteins in the colonic mucosa of CD rats, which may be one of the mechanism in intestinal mucosal immunity caused by moxibustion therapy.