Background Although thyroid hormone （TH） has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role i...Background Although thyroid hormone （TH） has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role in statin responsiveness in patients with acute myocardial infarction （AMI）. Methods Consecutive 1091 hospitalized AMI patients in Fuwai hospital （Beijing, China） were enrolled into this current study. The study population was divided into three groups based on the intensity of statin treatment： low-intensity （n = 221）, moderate-intensity （n = 712） and high-intensity （n = 158）. Lipid levels were measured after statin therapy lasting for 10-14 days. The association between TH, lipid profile levels and achievement of low-density lipoprotein cholesterol （LDL-C） lowering goals was explored in patients with AMI on statin therapy. Results By general linear analysis, a significant linear trend between free triiodothyronine （FT3） and LDL-C level （linear coefficient r = -0.082, P = 0.001） and FT3 and total cholesterol （TC） level （r = -0.105, P = 0.031） was observed in the moderate-intensity statin group. A more apparent linear trend was detected in the high-intensity statin group （for LDL-C： r = -0.113, P = 0.005; for TC： r = -0.172, P = 0.029, respectively）. However, no significant correlation was observed in the low-intensity statin group. Compared with the low-FT3 group （defined as FT3 〈 1.79 pg/mL）, the OR （95% CI） for attaining a LDL-C 〈 3.0mmol/L was found to be 2.217 （1.001–4.839） in the higher FT3 group （〉 2.95 pg/mL）. The OR （95% CI） for attaining the more intensive goal （LDL-C 〈 1.8mmol/L） was 2.836 （1.014–5.182）. Conclusions Our study reveals that variation in FT3 levels is related to the cholesterol-lowering responsiveness of statins in AMI patients. These findings suggest that low FT3 may be a factor responsible for lack of LDL-C goal attainment and patients’ poor responsiveness to statin treatment.展开更多
The emergence of media convergence have so huge impact on paper-based media that paper-based media no longer has a monopoly. Some people assert that paper-based media will come to an end. However, the author believes ...The emergence of media convergence have so huge impact on paper-based media that paper-based media no longer has a monopoly. Some people assert that paper-based media will come to an end. However, the author believes that the paper media will not come to an end under the media convergence trend. It will develop parallel with media integration. The reason why the author has this view is that, on one hand, paper-based media has its unique physical characteristics. In the real world, paper media brought us the aesthetic experience by ＂five senses＂ . It cannot be replaced by the media convergence. The paper media will also make survival steering dimension; on the other hand, cultural heritage of the paper media make itself a unique appreciation of the value and not transcendent. Therefore, the paper media in the media convergence trend will continue to exist and turned to be ＂concept book＂ that admiring is the main part and reading supplemented.展开更多
基金We acknowledge the help from Wei LI, Yang WANG and Yan-Yan ZHAO （Medical Research ＆ Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Disease, China） with the statistical analyses. This work was supported by the National Natural Science Foundation of China （No. 81470485）, Capital Clinical Featured Application Research Project （No. z151100004015175）, and CAMS Innovation Fund for Medical Sciences （CIFMS 2016-I2M- 1-009）. The authors have no potential conflict of interest to declare.
文摘Background Although thyroid hormone （TH） has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role in statin responsiveness in patients with acute myocardial infarction （AMI）. Methods Consecutive 1091 hospitalized AMI patients in Fuwai hospital （Beijing, China） were enrolled into this current study. The study population was divided into three groups based on the intensity of statin treatment： low-intensity （n = 221）, moderate-intensity （n = 712） and high-intensity （n = 158）. Lipid levels were measured after statin therapy lasting for 10-14 days. The association between TH, lipid profile levels and achievement of low-density lipoprotein cholesterol （LDL-C） lowering goals was explored in patients with AMI on statin therapy. Results By general linear analysis, a significant linear trend between free triiodothyronine （FT3） and LDL-C level （linear coefficient r = -0.082, P = 0.001） and FT3 and total cholesterol （TC） level （r = -0.105, P = 0.031） was observed in the moderate-intensity statin group. A more apparent linear trend was detected in the high-intensity statin group （for LDL-C： r = -0.113, P = 0.005; for TC： r = -0.172, P = 0.029, respectively）. However, no significant correlation was observed in the low-intensity statin group. Compared with the low-FT3 group （defined as FT3 〈 1.79 pg/mL）, the OR （95% CI） for attaining a LDL-C 〈 3.0mmol/L was found to be 2.217 （1.001–4.839） in the higher FT3 group （〉 2.95 pg/mL）. The OR （95% CI） for attaining the more intensive goal （LDL-C 〈 1.8mmol/L） was 2.836 （1.014–5.182）. Conclusions Our study reveals that variation in FT3 levels is related to the cholesterol-lowering responsiveness of statins in AMI patients. These findings suggest that low FT3 may be a factor responsible for lack of LDL-C goal attainment and patients’ poor responsiveness to statin treatment.
文摘The emergence of media convergence have so huge impact on paper-based media that paper-based media no longer has a monopoly. Some people assert that paper-based media will come to an end. However, the author believes that the paper media will not come to an end under the media convergence trend. It will develop parallel with media integration. The reason why the author has this view is that, on one hand, paper-based media has its unique physical characteristics. In the real world, paper media brought us the aesthetic experience by ＂five senses＂ . It cannot be replaced by the media convergence. The paper media will also make survival steering dimension; on the other hand, cultural heritage of the paper media make itself a unique appreciation of the value and not transcendent. Therefore, the paper media in the media convergence trend will continue to exist and turned to be ＂concept book＂ that admiring is the main part and reading supplemented.
