目的:探讨含重组人碱性成纤维细胞生长因子(recombinant human basic fibroblast growth factor,rhbFGF)和重组人骨形态发生蛋白-2(recombinant human bone morphogenetic protein-2,rhBMP-2)骨水泥在骨质疏松性腰椎压缩性骨折(osteopor...目的:探讨含重组人碱性成纤维细胞生长因子(recombinant human basic fibroblast growth factor,rhbFGF)和重组人骨形态发生蛋白-2(recombinant human bone morphogenetic protein-2,rhBMP-2)骨水泥在骨质疏松性腰椎压缩性骨折(osteoporotic vertebral compression fracture,OVCF)患者经皮椎体后凸成形术(percutaneous kyphoplasty,PKP)治疗的应用价值。方法:回顾性分析2018年1月至2021年1月收治的103例行PKP手术治疗的OVCF患者,男40例,女63例;年龄61~78(65.72±3.29)岁。受伤原因:滑倒33例,跌倒42例,提重物受伤28例。根据填充骨水泥不同分为3组:磷酸钙组34例,男14例,女20例,年龄(65.1±3.3)岁,填充磷酸钙骨水泥;rhBMP-2组34例,男12例,女22例,年龄(64.8±3.2)岁,填充含rhBMP-2的骨水泥;rhbFGF+rhBMP-2组35例,男14例,女21例,年龄(65.1±3.6)岁,填充含rhbFGF和rhBMP-2的骨水泥。比较3组Oswestry功能障碍指数(Oswestry dysfunction index,ODI)、骨密度、椎体前缘丢失高度、伤椎前缘压缩率、疼痛视觉模拟评分(visual simulation score,VAS)及再骨折发生率。结果:所有患者获得12个月随访。3组术后ODI、VAS呈下降(P<0.001),骨密度增高(P<0.001),椎体前缘丢失高度、伤椎前缘压缩率呈先下降后缓慢上升趋势(P<0.001),rhbFGF+rhBMP-2组术后第1、6、12个月ODI、VAS均低于rhBMP-2组和磷酸钙组(P<0.05),术后第6、12个月骨密度大于rhBMP-2组和磷酸钙组(P<0.05)。rhbFGF+rhBMP-2组术后第6、12个月椎体前缘丢失高度、伤椎前缘压缩率均低于rhBMP-2组和磷酸钙组(P<0.05)。3组再骨折发生率比较差异无统计学意义(P>0.05)。结论:含rhbFGF和rhBMP-2骨水泥可更有效地增加OVCF患者骨密度,获得术后满意的临床和放射学效果,显著改善临床症状。展开更多
随着全球各国逐渐步入老龄化社会,骨质疏松性椎体压缩性骨折(osteoporotic vertebral compression fracture, OVCF)的发病率越来越高,患者主要表现为腰背部的疼痛、活动受限,这严重影响患者的生活质量,所以早期诊断及治疗相当关键,目前...随着全球各国逐渐步入老龄化社会,骨质疏松性椎体压缩性骨折(osteoporotic vertebral compression fracture, OVCF)的发病率越来越高,患者主要表现为腰背部的疼痛、活动受限,这严重影响患者的生活质量,所以早期诊断及治疗相当关键,目前有几种不同的治疗策略:保守治疗、微创手术及传统开放性手术治疗。目前临床医生大多首选微创手术治疗,因其治疗效果好且见效快,但针对各种不同实际病情的患者,要选择适合患者的治疗方案。近些年来,为了患者获得更好的预后,医生们也不断对每种治疗方式研究改进,该文旨在对OVCF的治疗进展作一综述。With the aging of the world, the incidence of osteoporotic vertebral compression fracture (OVCF) is increasing. The main manifestations of patients are pain in the lower back and limited activity, which seriously affect the quality of life of patients. So the key to early diagnosis and treatment of quite, there are several different treatment strategies: conservative treatment, minimally invasive surgery and traditional open surgery. At present, most clinicians prefer minimally invasive surgery because of its good therapeutic effect and quick effect. However, for patients with different actual conditions, we should choose the appropriate treatment plan for the patient. In recent years, in order to get better prognosis patients, doctors and continuous improvement for each treatment study, this paper aims to review summarized the progress in treatment of OVCF.展开更多
文摘随着全球各国逐渐步入老龄化社会,骨质疏松性椎体压缩性骨折(osteoporotic vertebral compression fracture, OVCF)的发病率越来越高,患者主要表现为腰背部的疼痛、活动受限,这严重影响患者的生活质量,所以早期诊断及治疗相当关键,目前有几种不同的治疗策略:保守治疗、微创手术及传统开放性手术治疗。目前临床医生大多首选微创手术治疗,因其治疗效果好且见效快,但针对各种不同实际病情的患者,要选择适合患者的治疗方案。近些年来,为了患者获得更好的预后,医生们也不断对每种治疗方式研究改进,该文旨在对OVCF的治疗进展作一综述。With the aging of the world, the incidence of osteoporotic vertebral compression fracture (OVCF) is increasing. The main manifestations of patients are pain in the lower back and limited activity, which seriously affect the quality of life of patients. So the key to early diagnosis and treatment of quite, there are several different treatment strategies: conservative treatment, minimally invasive surgery and traditional open surgery. At present, most clinicians prefer minimally invasive surgery because of its good therapeutic effect and quick effect. However, for patients with different actual conditions, we should choose the appropriate treatment plan for the patient. In recent years, in order to get better prognosis patients, doctors and continuous improvement for each treatment study, this paper aims to review summarized the progress in treatment of OVCF.
