Transforming growth factor-beta （TGF-β）/bone morphogenic protein （BMP） signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of all metazoans. Dere...Transforming growth factor-beta （TGF-β）/bone morphogenic protein （BMP） signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of all metazoans. Deregulation of TGF-β/ BMP activity almost invariably leads to developmental defects and/or diseases, including cancer. The proper functioning of the TGF-β/BMP pathway depends on its constitutive and extensive communication with other signaling pathways, leading to synergistic or antagonistic effects and eventually desirable biological outcomes. The nature of such signaling cross-talk is overwhelmingly complex and highly context-dependent. Here we review the different modes of cross-talk between TGF-β/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/ Akt, Wnt, Hedgehog, Notch, and the interleukin/interferon-gamma/tumor necrosis factor-alpha cytokines, with an emphasis on the underlying molecular mechanisms.展开更多
The c-Jun NH2-terminal Kinase (JNK) pathway representsone sub-group of the mitogen-activated protein (MAP)kinases which plays an important role in variousinflammatory diseases states, including inflammatorybowel disea...The c-Jun NH2-terminal Kinase (JNK) pathway representsone sub-group of the mitogen-activated protein (MAP)kinases which plays an important role in variousinflammatory diseases states, including inflammatorybowel disease (IBD). Significant progress towardsunderstanding the function of the JNK signaling pathwayhas been achieved during the past few years. Blockadeof the JNK pathway with JNK inhibitors in animal modelsof IBD lead to resolution of intestinal inflammation.Current data suggest specific JNK inhibitors hold promiseas novel therapies in IBD.展开更多
The multi-linear variable separation approach method is very useful to solve (2+1)-dimensional integrable systems. In this letter, we extend this method to solve (1+1)-dimensional Boiti system, (2+1)-dimensional Burge...The multi-linear variable separation approach method is very useful to solve (2+1)-dimensional integrable systems. In this letter, we extend this method to solve (1+1)-dimensional Boiti system, (2+1)-dimensional Burgers system, (2+1)-dimensional breaking soliton system, and (2+1)-dimensional Maccari system. Some new exact solutions are obtained and the universal formula obtained from many (2+1)-dimensional systems is extended or modified.展开更多
By means of a special Painleve—Baecklund transformation and a multilinearvariable separation approach, an exact solution with arbitrary functions of the (2+1)-dimensionalBoiti-Leon-Pempinelli system (BLP) is derived....By means of a special Painleve—Baecklund transformation and a multilinearvariable separation approach, an exact solution with arbitrary functions of the (2+1)-dimensionalBoiti-Leon-Pempinelli system (BLP) is derived. Based on the derived variable separation solution, weobtain some special soliton fission and fusion solutions for the higher dimensional BLP system.展开更多
文摘Transforming growth factor-beta （TGF-β）/bone morphogenic protein （BMP） signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of all metazoans. Deregulation of TGF-β/ BMP activity almost invariably leads to developmental defects and/or diseases, including cancer. The proper functioning of the TGF-β/BMP pathway depends on its constitutive and extensive communication with other signaling pathways, leading to synergistic or antagonistic effects and eventually desirable biological outcomes. The nature of such signaling cross-talk is overwhelmingly complex and highly context-dependent. Here we review the different modes of cross-talk between TGF-β/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/ Akt, Wnt, Hedgehog, Notch, and the interleukin/interferon-gamma/tumor necrosis factor-alpha cytokines, with an emphasis on the underlying molecular mechanisms.
文摘The c-Jun NH2-terminal Kinase (JNK) pathway representsone sub-group of the mitogen-activated protein (MAP)kinases which plays an important role in variousinflammatory diseases states, including inflammatorybowel disease (IBD). Significant progress towardsunderstanding the function of the JNK signaling pathwayhas been achieved during the past few years. Blockadeof the JNK pathway with JNK inhibitors in animal modelsof IBD lead to resolution of intestinal inflammation.Current data suggest specific JNK inhibitors hold promiseas novel therapies in IBD.
文摘The multi-linear variable separation approach method is very useful to solve (2+1)-dimensional integrable systems. In this letter, we extend this method to solve (1+1)-dimensional Boiti system, (2+1)-dimensional Burgers system, (2+1)-dimensional breaking soliton system, and (2+1)-dimensional Maccari system. Some new exact solutions are obtained and the universal formula obtained from many (2+1)-dimensional systems is extended or modified.
基金国家自然科学基金，the Scientific Research Fund of Educational Department of Zhejiang Province of China under，浙江省自然科学基金
文摘By means of a special Painleve—Baecklund transformation and a multilinearvariable separation approach, an exact solution with arbitrary functions of the (2+1)-dimensionalBoiti-Leon-Pempinelli system (BLP) is derived. Based on the derived variable separation solution, weobtain some special soliton fission and fusion solutions for the higher dimensional BLP system.
