To determine the effect of growth hormone (GH) on body composition and motor development in infants and toddlers with Prader-Willi syndrome (PWS). Twenty-nine subjects with PWS (4-37 months of age) were randomized to ...To determine the effect of growth hormone (GH) on body composition and motor development in infants and toddlers with Prader-Willi syndrome (PWS). Twenty-nine subjects with PWS (4-37 months of age) were randomized to GH treatment (1mg/m2/day) or observation for 12 months. Percent body fat, lean body mass, and bone mineral density were measured by dual x-ray absorptiometry; energy expenditure was measured by deuterium dilution; and motor constructs of mobility (M)-and stability (S) were assessed using the Toddler Infant Motor Evaluation (TIME). GH-treated subjects, compared with controls, demonstrated decreased percent body fat (mean, 22. 6% ± 8. 9% vs 28. 5% ± 7. 9% ; P < . 001), increased lean body mass (mean, 9. 82 ± 1. 9 kg vs 6. 3 ± 1. 9 kg; P < . 001), and increased height velocity Z scores (mean, 5. 0 ± 1. 8 vs 1. 4 ± 1. 0; P < .001). Patients who began GH before 18 months of age showed higher mobility skill acquisition compared with controls within the same age range (mean increase in raw score, 284 ± 105 vs 206 ± 63; P < . 05). GH treatment of infants and toddlers with PWS for 12 months significantly improves body composition and when begun before 18 months of age increases mobility skill acquisition. These results suggest that GH therapy instituted early in life may lessen deterioration of body composition in PWS while also accelerating motor development.展开更多
The purpose of this study was to determine whether there is a difference in body composition and the factors that are associated with fat mass in the large-for -gestational -age infants of women with gestational diabe...The purpose of this study was to determine whether there is a difference in body composition and the factors that are associated with fat mass in the large-for -gestational -age infants of women with gestational diabetes mellitus compared with the large -for -gestational -age infants of women with normal glucose tolerance levels.Large for gestational age was defined as weigh t >90th percentile for gestational age,race,and sex on the basis of our popula-tion’s normative data.Anthropometric me asurements and /or total body electrical conductivity estimated body com-position that included fat mass,percent body fat,and lean body mass were obtained.Multiple stepwise regression was used to determine factors correlating with fat mass.Fifty cases of women with gestational diab etes mellitus and 52cases of women with normal glucose to lerance levels were evaluated.Infants of mothers with g estational diabetes mellitus had increased fat mass(662vs 563g;P =.02)and percent body fat(16.2%vs 13.5%;P =.002)but decreased lean body mass(3400vs 3557g;P =.0009),as compared with infants of mothers w ith normal glucose tolerance levels,despite similar b irth weights.Stepwise regression on all 102women showed ge stational age and a diagnosis of gestational diabetes m ellitus correlated with fat mass(r2 =0.11;P =.001).For gestational dia-betesmellitus alone,both gestatio nal age and fasting value of the oral glucose tolerance test co rrelated with fatmass and percent body fat(r 2 =0.33P=.0009and r 2 =0.26P =.005,respectively).Large -for -gestational -age infants of mothers with gestational diabetes mellitus have increased fat mass and decreased lean body mass compared with infants of mothers with normal g lucose tolerance lev-els.In gestational diabetes mellit us,gestational age and fasting value of the oral glucose tolerance test correlated best with fat mass.展开更多
0032335 1998年的内分泌学[德]/MllerB//Schweiz Med Wochenschr.-1999,129(1/2).-20～21 同医图0032336 Werner 综合征[德,英摘]/Schulthess G//Dtsch Med Wochenschr.-1999,124(11).-314～320 同医图0032337 生长激素治疗可逆转生长...0032335 1998年的内分泌学[德]/MllerB//Schweiz Med Wochenschr.-1999,129(1/2).-20～21 同医图0032336 Werner 综合征[德,英摘]/Schulthess G//Dtsch Med Wochenschr.-1999,124(11).-314～320 同医图0032337 生长激素治疗可逆转生长激素缺乏成人患者的早期动脉粥样硬化/PfeiferM//J Clin Endoc Metab.-1999,84(2).-453～457展开更多
文摘To determine the effect of growth hormone (GH) on body composition and motor development in infants and toddlers with Prader-Willi syndrome (PWS). Twenty-nine subjects with PWS (4-37 months of age) were randomized to GH treatment (1mg/m2/day) or observation for 12 months. Percent body fat, lean body mass, and bone mineral density were measured by dual x-ray absorptiometry; energy expenditure was measured by deuterium dilution; and motor constructs of mobility (M)-and stability (S) were assessed using the Toddler Infant Motor Evaluation (TIME). GH-treated subjects, compared with controls, demonstrated decreased percent body fat (mean, 22. 6% ± 8. 9% vs 28. 5% ± 7. 9% ; P < . 001), increased lean body mass (mean, 9. 82 ± 1. 9 kg vs 6. 3 ± 1. 9 kg; P < . 001), and increased height velocity Z scores (mean, 5. 0 ± 1. 8 vs 1. 4 ± 1. 0; P < .001). Patients who began GH before 18 months of age showed higher mobility skill acquisition compared with controls within the same age range (mean increase in raw score, 284 ± 105 vs 206 ± 63; P < . 05). GH treatment of infants and toddlers with PWS for 12 months significantly improves body composition and when begun before 18 months of age increases mobility skill acquisition. These results suggest that GH therapy instituted early in life may lessen deterioration of body composition in PWS while also accelerating motor development.
文摘The purpose of this study was to determine whether there is a difference in body composition and the factors that are associated with fat mass in the large-for -gestational -age infants of women with gestational diabetes mellitus compared with the large -for -gestational -age infants of women with normal glucose tolerance levels.Large for gestational age was defined as weigh t >90th percentile for gestational age,race,and sex on the basis of our popula-tion’s normative data.Anthropometric me asurements and /or total body electrical conductivity estimated body com-position that included fat mass,percent body fat,and lean body mass were obtained.Multiple stepwise regression was used to determine factors correlating with fat mass.Fifty cases of women with gestational diab etes mellitus and 52cases of women with normal glucose to lerance levels were evaluated.Infants of mothers with g estational diabetes mellitus had increased fat mass(662vs 563g;P =.02)and percent body fat(16.2%vs 13.5%;P =.002)but decreased lean body mass(3400vs 3557g;P =.0009),as compared with infants of mothers w ith normal glucose tolerance levels,despite similar b irth weights.Stepwise regression on all 102women showed ge stational age and a diagnosis of gestational diabetes m ellitus correlated with fat mass(r2 =0.11;P =.001).For gestational dia-betesmellitus alone,both gestatio nal age and fasting value of the oral glucose tolerance test co rrelated with fatmass and percent body fat(r 2 =0.33P=.0009and r 2 =0.26P =.005,respectively).Large -for -gestational -age infants of mothers with gestational diabetes mellitus have increased fat mass and decreased lean body mass compared with infants of mothers with normal g lucose tolerance lev-els.In gestational diabetes mellit us,gestational age and fasting value of the oral glucose tolerance test correlated best with fat mass.
文摘0032335 1998年的内分泌学[德]/MllerB//Schweiz Med Wochenschr.-1999,129(1/2).-20～21 同医图0032336 Werner 综合征[德,英摘]/Schulthess G//Dtsch Med Wochenschr.-1999,124(11).-314～320 同医图0032337 生长激素治疗可逆转生长激素缺乏成人患者的早期动脉粥样硬化/PfeiferM//J Clin Endoc Metab.-1999,84(2).-453～457
