目的:系统评价rhGH用于治疗亚洲特发性身材矮小症的短期和长期效果以及相关安全性。方法:计算机检索PubMed、Cochrane图书馆、OVID、EBSCO、Web of science;中文数据库:中国知网数据库(CNKI)、中国维普科技期刊数据库(VIP)和万方数据库(...目的:系统评价rhGH用于治疗亚洲特发性身材矮小症的短期和长期效果以及相关安全性。方法:计算机检索PubMed、Cochrane图书馆、OVID、EBSCO、Web of science;中文数据库:中国知网数据库(CNKI)、中国维普科技期刊数据库(VIP)和万方数据库(Wangfang)发表的rhGH治疗亚洲特发性身材矮小症的RCT文献,检索时间均从建库至2019年7月13日。对符合纳入标准的文献进行资料提取,并采用Cochrane系统评价手册5.1.0进行质量评价后,使用stata12.0进行meta分析。结果:纳入文献14篇,共1290例ISS患儿,其中试验组667例,对照组623例。治疗后骨龄12篇,治疗后生长速度13篇,治疗后身高6篇,治疗后成人身高5篇,Meta分析生长速度、治疗后身高、治疗后成人身高和疗程为1年的治疗后骨龄比较差异均有统计学意义(P<0.05),且rhGH治疗组高于对照组(P<0.05);而对疗程为6个月的治疗后骨龄、疗程为大于1年的治疗后骨龄比较、暂时性血糖身高,甲状腺功能异常或膝部疼痛的不良反应发生率比较差异均无统计学意义(P>0.05)。结论:rhGH治疗特发性身材矮小症有效果,且不会明显增加不良反应发生率。展开更多
Aim: 1) To assess the reliability and validity of the Swedish version of the Child Health Questionnaire (CHQ), 2) to determine the correlation between children’ s and parents’ responses to the CHQ, and 3) to describ...Aim: 1) To assess the reliability and validity of the Swedish version of the Child Health Questionnaire (CHQ), 2) to determine the correlation between children’ s and parents’ responses to the CHQ, and 3) to describe and compare responses to the CHQ of four diagnostic groups. Methods: A total of 199 Swedish children aged 9- 16 with diagnoses of asthma (n = 53), diabetes (n = 48), short stature (n = 51) and juvenile chronic arthritis (JCA, n = 47) and their parents answered the CHQ and relevant validation instruments at a clinic check- up. Coefficient alphas were determined for all dimensions of the instrument, and all but four had acceptable to very good reliability (0.75- 0.94). Results: Concerning construct validity, the CHQ correlated significantly with appropriate dimensions of the validation instruments. In general, there were significant correlations between the children’ s and parents’ responses. Comparisons between the diagnostic groups showed several significant differences. The short stature group had the highest quality of life and the JCA group the lowest. There were no sex differences, but children who had not reached puberty scored better on the dimensions of mental health and self- esteem. Conclusion: The Swedish version of the CHQ is a reliable and valid instrument. Furthermore, it is recommended to ask children themselves about their healthrelated quality of life.展开更多
文摘目的:系统评价rhGH用于治疗亚洲特发性身材矮小症的短期和长期效果以及相关安全性。方法:计算机检索PubMed、Cochrane图书馆、OVID、EBSCO、Web of science;中文数据库:中国知网数据库(CNKI)、中国维普科技期刊数据库(VIP)和万方数据库(Wangfang)发表的rhGH治疗亚洲特发性身材矮小症的RCT文献,检索时间均从建库至2019年7月13日。对符合纳入标准的文献进行资料提取,并采用Cochrane系统评价手册5.1.0进行质量评价后,使用stata12.0进行meta分析。结果:纳入文献14篇,共1290例ISS患儿,其中试验组667例,对照组623例。治疗后骨龄12篇,治疗后生长速度13篇,治疗后身高6篇,治疗后成人身高5篇,Meta分析生长速度、治疗后身高、治疗后成人身高和疗程为1年的治疗后骨龄比较差异均有统计学意义(P<0.05),且rhGH治疗组高于对照组(P<0.05);而对疗程为6个月的治疗后骨龄、疗程为大于1年的治疗后骨龄比较、暂时性血糖身高,甲状腺功能异常或膝部疼痛的不良反应发生率比较差异均无统计学意义(P>0.05)。结论:rhGH治疗特发性身材矮小症有效果,且不会明显增加不良反应发生率。
文摘Aim: 1) To assess the reliability and validity of the Swedish version of the Child Health Questionnaire (CHQ), 2) to determine the correlation between children’ s and parents’ responses to the CHQ, and 3) to describe and compare responses to the CHQ of four diagnostic groups. Methods: A total of 199 Swedish children aged 9- 16 with diagnoses of asthma (n = 53), diabetes (n = 48), short stature (n = 51) and juvenile chronic arthritis (JCA, n = 47) and their parents answered the CHQ and relevant validation instruments at a clinic check- up. Coefficient alphas were determined for all dimensions of the instrument, and all but four had acceptable to very good reliability (0.75- 0.94). Results: Concerning construct validity, the CHQ correlated significantly with appropriate dimensions of the validation instruments. In general, there were significant correlations between the children’ s and parents’ responses. Comparisons between the diagnostic groups showed several significant differences. The short stature group had the highest quality of life and the JCA group the lowest. There were no sex differences, but children who had not reached puberty scored better on the dimensions of mental health and self- esteem. Conclusion: The Swedish version of the CHQ is a reliable and valid instrument. Furthermore, it is recommended to ask children themselves about their healthrelated quality of life.
