Background: In paediatric clinical practice treatment is often adjusted in rel ation to body size, for example the calculation of pharmacological and dialysis dosages. In addition to use of body weight, for some purpo...Background: In paediatric clinical practice treatment is often adjusted in rel ation to body size, for example the calculation of pharmacological and dialysis dosages. In addition to use of body weight, for some purposes total body water ( TBW) and surface area are estimated from anthropometry using equations developed several decades previously. Whether such equations remain valid in contemporary populations is not known. Methods: Total body water was measured using deuteriu m dilution in 672 subjects (265 infants aged < 1 year; 407 children and adolesce nts aged 1-19 years) during the period 1990-2003. TBW was predicted (a) using published equations, and (b) directly from data on age, sex, weight, and height. Results: Previously published equations, based on data obtained before 1970, si gnificantly overestimated TBW, with average biases ranging from 4%to 11%. For all equations, the overestimation of TBW was greatest in infancy. New equations were generated. The best equation, incorporating log weight, log height, age, an d sex, had a standard error of the estimate of 7.8%. Conclusions: Secular trend s in the nutritional status of infants and children are altering the relation be tween age or weight and TBW. Equations developed in previous decades significant ly overestimate TBW in all age groups, especially infancy; however, the relation between TBW and weight may continue to change. This scenario is predicted to ap ply more generally to many aspects of paediatric clinical practice in which dosa ges are calculated on the basis of anthropometric data collected in previous dec ades.展开更多
Objective: It has been recommended that age-related centile curves of anthropometric indexes(such as height, weight) be used rountinly to evaluate the growth and development statues in children. Presented here is the ...Objective: It has been recommended that age-related centile curves of anthropometric indexes(such as height, weight) be used rountinly to evaluate the growth and development statues in children. Presented here is the age-related height centile curves for children aged 0-18 years in Shaanxi, China,1995. Methods: Data of the Shaanxi population were retrieved from The Third Nationwide Growth Survey to construct the age-related height centile curves. The LMS method was used for curve fitting; all analyses were carried out on the basis of different sexes through a special program for LMS(λ-median-coefficient) method which was devised by Cole TJ. Results: Centile curves for boys and girls, showing similar age-related features but girls'puberty coming two years earlier than boys'. The period of puberty growth increment was about 2 years longer for boys. At age 18, boys were taller than girls for about 14 cm. Compared with height standard of NCHS(national center of health statistics), Shaanxi children were taller than American children before 14 years for boys, 12 years for girls, but after 15 years for boys and 13 years for girls, Shaanxi children were shorter than American ones. At age 18, Shaanxi children was 5.6 cm for boys and 4.9 cm for girls shorter than NCHS. Shaanxi children's height increase range from 1958 to 1995 at the same age was 4.9-15.1 cm ,with the mean of 9.59 cm for boys, and 3.7-12.5 cm, with the mean of 8.38 cm for girls. Between 1958-1995, the increasing velocity every ten years were 2.57 cm for boys and 2.26 cm for girls, which indicated that the children have reached the optimum. Conclusion: By means of LMS method, we constructed age-related height centile curves for Shaanxi children aged 0-18 years, these height centile curves are the first one for the Chinese children. It can be used as a reference for assessing growth and development status of Shaanxi children aged 0-18 years.展开更多
文摘Background: In paediatric clinical practice treatment is often adjusted in rel ation to body size, for example the calculation of pharmacological and dialysis dosages. In addition to use of body weight, for some purposes total body water ( TBW) and surface area are estimated from anthropometry using equations developed several decades previously. Whether such equations remain valid in contemporary populations is not known. Methods: Total body water was measured using deuteriu m dilution in 672 subjects (265 infants aged < 1 year; 407 children and adolesce nts aged 1-19 years) during the period 1990-2003. TBW was predicted (a) using published equations, and (b) directly from data on age, sex, weight, and height. Results: Previously published equations, based on data obtained before 1970, si gnificantly overestimated TBW, with average biases ranging from 4%to 11%. For all equations, the overestimation of TBW was greatest in infancy. New equations were generated. The best equation, incorporating log weight, log height, age, an d sex, had a standard error of the estimate of 7.8%. Conclusions: Secular trend s in the nutritional status of infants and children are altering the relation be tween age or weight and TBW. Equations developed in previous decades significant ly overestimate TBW in all age groups, especially infancy; however, the relation between TBW and weight may continue to change. This scenario is predicted to ap ply more generally to many aspects of paediatric clinical practice in which dosa ges are calculated on the basis of anthropometric data collected in previous dec ades.
文摘Objective: It has been recommended that age-related centile curves of anthropometric indexes(such as height, weight) be used rountinly to evaluate the growth and development statues in children. Presented here is the age-related height centile curves for children aged 0-18 years in Shaanxi, China,1995. Methods: Data of the Shaanxi population were retrieved from The Third Nationwide Growth Survey to construct the age-related height centile curves. The LMS method was used for curve fitting; all analyses were carried out on the basis of different sexes through a special program for LMS(λ-median-coefficient) method which was devised by Cole TJ. Results: Centile curves for boys and girls, showing similar age-related features but girls'puberty coming two years earlier than boys'. The period of puberty growth increment was about 2 years longer for boys. At age 18, boys were taller than girls for about 14 cm. Compared with height standard of NCHS(national center of health statistics), Shaanxi children were taller than American children before 14 years for boys, 12 years for girls, but after 15 years for boys and 13 years for girls, Shaanxi children were shorter than American ones. At age 18, Shaanxi children was 5.6 cm for boys and 4.9 cm for girls shorter than NCHS. Shaanxi children's height increase range from 1958 to 1995 at the same age was 4.9-15.1 cm ,with the mean of 9.59 cm for boys, and 3.7-12.5 cm, with the mean of 8.38 cm for girls. Between 1958-1995, the increasing velocity every ten years were 2.57 cm for boys and 2.26 cm for girls, which indicated that the children have reached the optimum. Conclusion: By means of LMS method, we constructed age-related height centile curves for Shaanxi children aged 0-18 years, these height centile curves are the first one for the Chinese children. It can be used as a reference for assessing growth and development status of Shaanxi children aged 0-18 years.
