Objective. To assess the health-related quality of life (HRQL) of 8-to 12-year-old children undergoing therapy for cancer or childhood-cancer survivors by using the Minneapolis-Manchester Quality of Life-Youth Form(MM...Objective. To assess the health-related quality of life (HRQL) of 8-to 12-year-old children undergoing therapy for cancer or childhood-cancer survivors by using the Minneapolis-Manchester Quality of Life-Youth Form(MMQL-YF),a comprehensive,multidimensional self-report instrument with demonstrable reliability and validity. Design,Setting,and Patients. The MMQL-YF consists of 32 items comprising 4 scales:physical functioning,psychologic functioning,physical symptoms,and outlook on life. Scoring on the MMQL ranges from 1 to 5; 5 indicates maximal HRQL. An overall quality-of life (QOL) score is also computed. By using a cross-sectional study design,the MMQL-YF was administered to 90 off-therapy cancer survivors,72 children with cancer undergoing active therapy,and 481 healthy children without a history of cancer or other chronic disease. Results. Compared with healthy controls,children actively undergoing cancer treatment report low overall QOL,physical functioning,and outlook-on-life scores. However,off-therapy survivors report a superior overall QOL,compared with age-matched healthy controls. Conclusions. Young survivors of childhood cancer report a favorable HRQL relative to healthy controls. These results are reassuring,suggesting that this group of survivors may have been too young to encounter some of the negative psychosocial impacts of cancer and its treatment.展开更多
The pathophysiology of irritable bowel syndrome（IBS） is complex and not fully understood, so the aim of this study was to evaluate whether visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction,...The pathophysiology of irritable bowel syndrome（IBS） is complex and not fully understood, so the aim of this study was to evaluate whether visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction, and low-grade inflammation of the gut wall are associated with diarrhea-predominant IBS（D-IBS）. Sixty-two patients with D-IBS and 20 control subjects participated in the study. Using the ascending method of limits（AML） protocol, we demonstrated that D-IBS patients had significantly lower sensory thresholds compared with healthy controls（P〈0.001）. Using diverse methods, especially the ischemic sensitivity test, for the first time in China, we confirmed that D-IBS patients have somatic hypersensitivity. They had a significantly higher systolic blood pressure and heart rate after a cold stimulus, indicative of autonomic cardiovascular dysfunction. Compared with the control group, D-IBS patients had a significantly higher level of calprotectin（P〈0.001）. We also found significant correlations between visceral and somatic hypersensitivity, visceral hypersensitivity and autonomic cardiovascular dysfunction, and somatic hypersensitivity and autonomic cardiovascular dysfunction. Our findings may provide valuable suggestions for the treatment of D-IBS.展开更多
文摘Objective. To assess the health-related quality of life (HRQL) of 8-to 12-year-old children undergoing therapy for cancer or childhood-cancer survivors by using the Minneapolis-Manchester Quality of Life-Youth Form(MMQL-YF),a comprehensive,multidimensional self-report instrument with demonstrable reliability and validity. Design,Setting,and Patients. The MMQL-YF consists of 32 items comprising 4 scales:physical functioning,psychologic functioning,physical symptoms,and outlook on life. Scoring on the MMQL ranges from 1 to 5; 5 indicates maximal HRQL. An overall quality-of life (QOL) score is also computed. By using a cross-sectional study design,the MMQL-YF was administered to 90 off-therapy cancer survivors,72 children with cancer undergoing active therapy,and 481 healthy children without a history of cancer or other chronic disease. Results. Compared with healthy controls,children actively undergoing cancer treatment report low overall QOL,physical functioning,and outlook-on-life scores. However,off-therapy survivors report a superior overall QOL,compared with age-matched healthy controls. Conclusions. Young survivors of childhood cancer report a favorable HRQL relative to healthy controls. These results are reassuring,suggesting that this group of survivors may have been too young to encounter some of the negative psychosocial impacts of cancer and its treatment.
基金Project supported by the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period of China(No.2014BAI08B02)the National Science & Technology Major Projects(Major Drug Discovery)of China(No.2012ZX09103201-021)
文摘The pathophysiology of irritable bowel syndrome（IBS） is complex and not fully understood, so the aim of this study was to evaluate whether visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction, and low-grade inflammation of the gut wall are associated with diarrhea-predominant IBS（D-IBS）. Sixty-two patients with D-IBS and 20 control subjects participated in the study. Using the ascending method of limits（AML） protocol, we demonstrated that D-IBS patients had significantly lower sensory thresholds compared with healthy controls（P〈0.001）. Using diverse methods, especially the ischemic sensitivity test, for the first time in China, we confirmed that D-IBS patients have somatic hypersensitivity. They had a significantly higher systolic blood pressure and heart rate after a cold stimulus, indicative of autonomic cardiovascular dysfunction. Compared with the control group, D-IBS patients had a significantly higher level of calprotectin（P〈0.001）. We also found significant correlations between visceral and somatic hypersensitivity, visceral hypersensitivity and autonomic cardiovascular dysfunction, and somatic hypersensitivity and autonomic cardiovascular dysfunction. Our findings may provide valuable suggestions for the treatment of D-IBS.
