世界卫生组织(World Health Organization,WHO)国际癌症研究机构发布的数据显示,乳腺癌现已成为全球女性发病率最高的恶性肿瘤,严重威胁女性健康。2022年乳腺癌基础与转化研究领域进展颇丰,深化了对乳腺癌分子本质的认识,为乳腺癌精准...世界卫生组织(World Health Organization,WHO)国际癌症研究机构发布的数据显示,乳腺癌现已成为全球女性发病率最高的恶性肿瘤,严重威胁女性健康。2022年乳腺癌基础与转化研究领域进展颇丰,深化了对乳腺癌分子本质的认识,为乳腺癌精准治疗提供了新的思路。本文从肿瘤代谢、肿瘤微环境、微生物与肿瘤、肿瘤转移、肿瘤耐药与药物筛选、多组学研究、人工智能共7个方面对2022年乳腺癌基础与转化研究的年度进展进行总结,并对乳腺癌研究未来的发展方向进行展望,以期为乳腺癌研究的进一步深化提供参考。展开更多
AIM: To investigate the correlation between uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphisms and irinotecan-associated side effects and parameters of drug efficacy in patients with metastat...AIM: To investigate the correlation between uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphisms and irinotecan-associated side effects and parameters of drug efficacy in patients with metastatic colorectal cancer (mCRC) receiving a low-dose weekly irinotecan chemotherapeutic regimen. METHODS: Genotypes were retrospectively evaluated by gene scan analysis on the ABI 310 sequencer of the TATAA box in the promoter region of the UGT1A1 gene in blood samples from 105 patients who had received 1st line irinotecan-based chemotherapy for mCRC. RESULTS: The distribution of the genotypes was as follows: wild type genotype (WT) (6/6 ) 39.0%, heterozygous genotype (6/7) 49.5%, and homozygous genotype (7/7) 9.5%. The overall response rate (OR) was similar between patients carrying the (6/7, 7/7) or the WT genotype (6/6) (44.3% vs 43.2%, P = 0.75). Neither time to progression [(TTP) 8.1 vs 8.2 mo, P = 0.97] nor overall survival [(OS) 21.2 vs 18.9 mo, P = 0.73] differed significantly in patients who carried the(6/6) when compared to the (6/7, 7/7) genotype. No significant differences in toxicity were observed: Grade 3 and 4 delayed diarrhoea [(6/7, 7/7) vs (6/6); 13.0% vs 6.2%, P =0.08], treatment delays [(6/7, 7/7) vs (6/6); 25.1% vs 19.3%, P = 0.24] or dose reductions [(6/7, 7/7) vs (6/6); 21.5% vs 27.2%, P = 0.07].CONCLUSION: This analysis demonstrates the non-significant influence of the UGT1A1 gene polymorphism on efficacy and rate of irinotecan-associated toxicity in mCRC patients receiving low-dose irinotecan based chemotherapy.展开更多
This paper examines the role of transformational leadership in transforming an organization into a knowledge based, then into learning organization so that it becomes an innovative company. Important features of the l...This paper examines the role of transformational leadership in transforming an organization into a knowledge based, then into learning organization so that it becomes an innovative company. Important features of the leader such and ability to assist in developing and accommodating the implementation of knowledge management programs, learning organization concepts and innovation protocols are discussed in this paper. This paper demonstrates that shifting the organization to become a knowledge based and then to be learning organization and finally to become innovative company could involve some unique attributes of a transformation leadership. In that regards, the paper also demonstrates that organizations need first to create, capture, transfer, and mobilize knowledge before it can be used for learning and then for innovation. The paper will present a method of a studying how successful innovation leaders of companies could found themselves acting in three roles namely： knowledge leader, learning leader and then innovation leader.展开更多
The dynamic model of a novel electric power steering （EPS） system integrated with active front steering function （the novel EPS system） is built. The concepts and quantitative expressions of the steering road feel...The dynamic model of a novel electric power steering （EPS） system integrated with active front steering function （the novel EPS system） is built. The concepts and quantitative expressions of the steering road feel, steering sensibility, and steering operation stability are introduced. Based on quality engineering theory, the optimization algorithm is proposed by integrating the Monte Carlo descriptive sampling, elitist non-dominated sorting genetic algorithm （NSGA-II） and 6-sigma design method. With the steering road feel and the steering portability as optimization targets, the system parameters are optimized by the proposed optimization algorithm. The simulation results show that the system optimized based on quality engineering theory can improve the steering road feel, guarantee steering stability and steering portability and thus provide a theoretical basis for the design and optimization of the novel electric power steering system.展开更多
Many researchers have studied the ocean carbon cycle model trying to regulate the level of CO2 in atmosphere from viewpoint of quantification. Unlike other researches, this paper analyzes the conversion process of car...Many researchers have studied the ocean carbon cycle model trying to regulate the level of CO2 in atmosphere from viewpoint of quantification. Unlike other researches, this paper analyzes the conversion process of carbon element in the ocean from the qualitative viewpoint. There are many complex roles in the ocean carbon cycle, and it is hard to represent the case that an entity plays different role in different environment. An ontology technology Hozo role theory developed by Osaka University Mizoguchi Laboratory is proposed as a solution. The basic concepts and representation mode of Hozo role theory is introduced. The conversion process of ocean carbon cycle is abstracted and an ontology model using Hozo role theory is proposed. Instead of comprehensive common ontology construction method, we propose our own ontology development steps. Then an ontology about ocean carbon cycle is built in order to describe and share the basic knowledge of ocean carbon cycle. A knowledge base of material circulation is proposed based on the ontology. Its construction framework is described and some knowledge base query examples are also illustrated. Conclusions show that the role theory can effectively solve the problem of multirole description in ocean carbon cycle, and knowledge reasoning based on ontology is also effective.展开更多
In the knowledge management domain, the conversion of tacit knowledge to explicit knowledge is critical because it is a prerequisite to the knowledge amplification process wherein knowledge becomes part of an organiza...In the knowledge management domain, the conversion of tacit knowledge to explicit knowledge is critical because it is a prerequisite to the knowledge amplification process wherein knowledge becomes part of an organization＇s knowledge network. Although codified knowledge and its capture is commonplace, tacit knowledge has up until recent years proved elusive in its inclusion within the organization＇s knowledge base. In this paper, the conversion process has been dealt with the help of protocols. It is learned that while structure may significantly improve the tacit to explicit conversion process, it also may matter how the structure is employed. It is anticipated that eventual successful modeling of such knowledge will ultimately be undertaken in several organizations with a view to improving information capture and transference.展开更多
Realizing personalized medicine requires integrating diverse data types with bioinformatics.The most vital data are genomic information for individuals that are from advanced next-generation sequencing(NGS) technologi...Realizing personalized medicine requires integrating diverse data types with bioinformatics.The most vital data are genomic information for individuals that are from advanced next-generation sequencing(NGS) technologies at present.The technologies continue to advance in terms of both decreasing cost and sequencing speed with concomitant increase in the amount and complexity of the data.The prodigious data together with the requisite computational pipelines for data analysis and interpretation are stressors to IT infrastructure and the scientists conducting the work alike.Bioinformatics is increasingly becoming the rate-limiting step with numerous challenges to be overcome for translating NGS data for personalized medicine.We review some key bioinformatics tasks,issues,and challenges in contexts of IT requirements,data quality,analysis tools and pipelines,and validation of biomarkers.展开更多
Biological light-driven proton pumps which could transfer light energy to electrical energy have aroused intense interest in the past years.Many related researches have been conducted to mimic this process in vitro be...Biological light-driven proton pumps which could transfer light energy to electrical energy have aroused intense interest in the past years.Many related researches have been conducted to mimic this process in vitro because of its potential significant applications.This review describes the progress in biomimetic photoelectric conversion systems based on different kinds of promising artificial membranes.Both biological bacteriorhodopsin and the photosensitive chemical molecules which could be used to achieve the photoelectric conversion function are discussed.Also a short outlook in this field is demonstrated at the end.展开更多
文摘世界卫生组织(World Health Organization,WHO)国际癌症研究机构发布的数据显示,乳腺癌现已成为全球女性发病率最高的恶性肿瘤,严重威胁女性健康。2022年乳腺癌基础与转化研究领域进展颇丰,深化了对乳腺癌分子本质的认识,为乳腺癌精准治疗提供了新的思路。本文从肿瘤代谢、肿瘤微环境、微生物与肿瘤、肿瘤转移、肿瘤耐药与药物筛选、多组学研究、人工智能共7个方面对2022年乳腺癌基础与转化研究的年度进展进行总结,并对乳腺癌研究未来的发展方向进行展望,以期为乳腺癌研究的进一步深化提供参考。
文摘AIM: To investigate the correlation between uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphisms and irinotecan-associated side effects and parameters of drug efficacy in patients with metastatic colorectal cancer (mCRC) receiving a low-dose weekly irinotecan chemotherapeutic regimen. METHODS: Genotypes were retrospectively evaluated by gene scan analysis on the ABI 310 sequencer of the TATAA box in the promoter region of the UGT1A1 gene in blood samples from 105 patients who had received 1st line irinotecan-based chemotherapy for mCRC. RESULTS: The distribution of the genotypes was as follows: wild type genotype (WT) (6/6 ) 39.0%, heterozygous genotype (6/7) 49.5%, and homozygous genotype (7/7) 9.5%. The overall response rate (OR) was similar between patients carrying the (6/7, 7/7) or the WT genotype (6/6) (44.3% vs 43.2%, P = 0.75). Neither time to progression [(TTP) 8.1 vs 8.2 mo, P = 0.97] nor overall survival [(OS) 21.2 vs 18.9 mo, P = 0.73] differed significantly in patients who carried the(6/6) when compared to the (6/7, 7/7) genotype. No significant differences in toxicity were observed: Grade 3 and 4 delayed diarrhoea [(6/7, 7/7) vs (6/6); 13.0% vs 6.2%, P =0.08], treatment delays [(6/7, 7/7) vs (6/6); 25.1% vs 19.3%, P = 0.24] or dose reductions [(6/7, 7/7) vs (6/6); 21.5% vs 27.2%, P = 0.07].CONCLUSION: This analysis demonstrates the non-significant influence of the UGT1A1 gene polymorphism on efficacy and rate of irinotecan-associated toxicity in mCRC patients receiving low-dose irinotecan based chemotherapy.
文摘This paper examines the role of transformational leadership in transforming an organization into a knowledge based, then into learning organization so that it becomes an innovative company. Important features of the leader such and ability to assist in developing and accommodating the implementation of knowledge management programs, learning organization concepts and innovation protocols are discussed in this paper. This paper demonstrates that shifting the organization to become a knowledge based and then to be learning organization and finally to become innovative company could involve some unique attributes of a transformation leadership. In that regards, the paper also demonstrates that organizations need first to create, capture, transfer, and mobilize knowledge before it can be used for learning and then for innovation. The paper will present a method of a studying how successful innovation leaders of companies could found themselves acting in three roles namely： knowledge leader, learning leader and then innovation leader.
基金Projects(51005115,51205191)supported by the National Natural Science Foundation of ChinaProject(QC201101)supported by the Visiting Scholar Foundation of the Automobile Engineering Key Laboratory of Jiangsu Province,China+1 种基金Project(SKLMT-KFKT-201105)supported by the Visiting Scholar Foundation of the State Key Laboratory of Mechanical Transmission in Chongqing University,ChinaProjects(NS2013015,NS2012086)supported by the Funds from the Postgraduate Creative Base in Nanjing University of Areonautics and Astronautics,and NUAA Research Funding,China
文摘The dynamic model of a novel electric power steering （EPS） system integrated with active front steering function （the novel EPS system） is built. The concepts and quantitative expressions of the steering road feel, steering sensibility, and steering operation stability are introduced. Based on quality engineering theory, the optimization algorithm is proposed by integrating the Monte Carlo descriptive sampling, elitist non-dominated sorting genetic algorithm （NSGA-II） and 6-sigma design method. With the steering road feel and the steering portability as optimization targets, the system parameters are optimized by the proposed optimization algorithm. The simulation results show that the system optimized based on quality engineering theory can improve the steering road feel, guarantee steering stability and steering portability and thus provide a theoretical basis for the design and optimization of the novel electric power steering system.
基金supported by the New Century Excellent Talents in University (NCET-07-0784)the Foundation of Henan Educational Committee (12A520003)
文摘Many researchers have studied the ocean carbon cycle model trying to regulate the level of CO2 in atmosphere from viewpoint of quantification. Unlike other researches, this paper analyzes the conversion process of carbon element in the ocean from the qualitative viewpoint. There are many complex roles in the ocean carbon cycle, and it is hard to represent the case that an entity plays different role in different environment. An ontology technology Hozo role theory developed by Osaka University Mizoguchi Laboratory is proposed as a solution. The basic concepts and representation mode of Hozo role theory is introduced. The conversion process of ocean carbon cycle is abstracted and an ontology model using Hozo role theory is proposed. Instead of comprehensive common ontology construction method, we propose our own ontology development steps. Then an ontology about ocean carbon cycle is built in order to describe and share the basic knowledge of ocean carbon cycle. A knowledge base of material circulation is proposed based on the ontology. Its construction framework is described and some knowledge base query examples are also illustrated. Conclusions show that the role theory can effectively solve the problem of multirole description in ocean carbon cycle, and knowledge reasoning based on ontology is also effective.
文摘In the knowledge management domain, the conversion of tacit knowledge to explicit knowledge is critical because it is a prerequisite to the knowledge amplification process wherein knowledge becomes part of an organization＇s knowledge network. Although codified knowledge and its capture is commonplace, tacit knowledge has up until recent years proved elusive in its inclusion within the organization＇s knowledge base. In this paper, the conversion process has been dealt with the help of protocols. It is learned that while structure may significantly improve the tacit to explicit conversion process, it also may matter how the structure is employed. It is anticipated that eventual successful modeling of such knowledge will ultimately be undertaken in several organizations with a view to improving information capture and transference.
文摘Realizing personalized medicine requires integrating diverse data types with bioinformatics.The most vital data are genomic information for individuals that are from advanced next-generation sequencing(NGS) technologies at present.The technologies continue to advance in terms of both decreasing cost and sequencing speed with concomitant increase in the amount and complexity of the data.The prodigious data together with the requisite computational pipelines for data analysis and interpretation are stressors to IT infrastructure and the scientists conducting the work alike.Bioinformatics is increasingly becoming the rate-limiting step with numerous challenges to be overcome for translating NGS data for personalized medicine.We review some key bioinformatics tasks,issues,and challenges in contexts of IT requirements,data quality,analysis tools and pipelines,and validation of biomarkers.
基金supported by the National Basic Research Program of China (2010CB934700,2009CB930404,2007CB936403,2007CB936400)National Natural Science Foundation of China (20974113,20920102036)
文摘Biological light-driven proton pumps which could transfer light energy to electrical energy have aroused intense interest in the past years.Many related researches have been conducted to mimic this process in vitro because of its potential significant applications.This review describes the progress in biomimetic photoelectric conversion systems based on different kinds of promising artificial membranes.Both biological bacteriorhodopsin and the photosensitive chemical molecules which could be used to achieve the photoelectric conversion function are discussed.Also a short outlook in this field is demonstrated at the end.
