Abstract： The shortest path problem in a network G is to find shortest paths between some specified source vertices and terminal vertices when the lengths of edges are given. The structure of the optimal solutions se...Abstract： The shortest path problem in a network G is to find shortest paths between some specified source vertices and terminal vertices when the lengths of edges are given. The structure of the optimal solutions set on the shortest paths is studied in this paper. First, the conditions of having unique shortest path between two distinguished vertices 8 and t in a network G are discussed; Second, the structural properties of 2-transformation ^-G graph G on the shortest-paths for G are presented heavily.展开更多
Colorectal cancer is the second most common malignant tumor in China.The FOLFOXIRI regimen,which combines 5-fluorouracil/leucovorin,oxaliplatin,and irinotecan,is a high-intensity and highly effective chemotherapy regi...Colorectal cancer is the second most common malignant tumor in China.The FOLFOXIRI regimen,which combines 5-fluorouracil/leucovorin,oxaliplatin,and irinotecan,is a high-intensity and highly effective chemotherapy regimen.However,the original regimen is poorly tolerated in Chinese patients.In order to promote the standardization and rational application of FOLFOXIRI regimen by clinicians in China,the“Chinese Expert Consensus on the Clinical Application of the Chinese Modified Triplet Combination with Irinotecan(CPT-11),Oxaliplatin(LOHP),Continuous Infusion 5-Fluorouracil,and Leucovorin for Colorectal Cancer”was formulated by the Committee of Colorectal Cancer in Chinese Southwest Oncology Group.Based on the mechanism underlying the combined three drugs and toxicity profile,the dosage of Chinese modified FOLFOXIRI(cmFOLFOXIRI)regimen and the management of adverse reactions are proposed.This consensus recommended that the FOLFOXIRI regimen be used in neoadjuvant,conversion,and palliative therapy for colorectal cancer under specific conditions.This consensus aimed to drive the application of cmFOLFOXIRI in the field of colorectal cancer in order to bring benefits to colorectal cancer patients.展开更多
文摘Abstract： The shortest path problem in a network G is to find shortest paths between some specified source vertices and terminal vertices when the lengths of edges are given. The structure of the optimal solutions set on the shortest paths is studied in this paper. First, the conditions of having unique shortest path between two distinguished vertices 8 and t in a network G are discussed; Second, the structural properties of 2-transformation ^-G graph G on the shortest-paths for G are presented heavily.
基金supported by The National Key Research and Development Plan of China[2019YFC1316003].
文摘Colorectal cancer is the second most common malignant tumor in China.The FOLFOXIRI regimen,which combines 5-fluorouracil/leucovorin,oxaliplatin,and irinotecan,is a high-intensity and highly effective chemotherapy regimen.However,the original regimen is poorly tolerated in Chinese patients.In order to promote the standardization and rational application of FOLFOXIRI regimen by clinicians in China,the“Chinese Expert Consensus on the Clinical Application of the Chinese Modified Triplet Combination with Irinotecan(CPT-11),Oxaliplatin(LOHP),Continuous Infusion 5-Fluorouracil,and Leucovorin for Colorectal Cancer”was formulated by the Committee of Colorectal Cancer in Chinese Southwest Oncology Group.Based on the mechanism underlying the combined three drugs and toxicity profile,the dosage of Chinese modified FOLFOXIRI(cmFOLFOXIRI)regimen and the management of adverse reactions are proposed.This consensus recommended that the FOLFOXIRI regimen be used in neoadjuvant,conversion,and palliative therapy for colorectal cancer under specific conditions.This consensus aimed to drive the application of cmFOLFOXIRI in the field of colorectal cancer in order to bring benefits to colorectal cancer patients.
