Ad Hoc网络中由于节点移动、计算限制等因素导致其拓扑结构多变,需要频繁重建路由,直接在原始拓扑上执行数据转发算法显得极其困难,影响分组转发可靠性和效率。利用社会网络和行为规律的知识,在构建连通子图的基础上,通过分析、预测节...Ad Hoc网络中由于节点移动、计算限制等因素导致其拓扑结构多变,需要频繁重建路由,直接在原始拓扑上执行数据转发算法显得极其困难,影响分组转发可靠性和效率。利用社会网络和行为规律的知识,在构建连通子图的基础上,通过分析、预测节点联系的时间、联系时间间隔和空间位置等方法,构建了一个联系时空的预测转发模型。通过仿真实验对该模型进行验证,结果表明:该模型能有效地预测并建立转发路由,在分组转发成功率、端到端平均时延以及平均路由开销等性能上较现有模型有较大的提升。展开更多
Microblogs currently play an important role in social communication. Hot topics currently being tweeted can quickly become popular within a very short time as a result of retweeting. Gaining an understanding of the re...Microblogs currently play an important role in social communication. Hot topics currently being tweeted can quickly become popular within a very short time as a result of retweeting. Gaining an understanding of the retweeting behavior is desirable for a number of tasks such as topic detection, personalized message recommendation, and fake information monitoring and prevention. Interestingly, the propagation of tweets bears some similarity to the spread of infectious diseases. We present a method to model the tweets' spread behavior in microblogs based on the classic Susceptible-Infectious-Susceptible (SIS) epidemic model that was developed in the medical field for the spread of infectious diseases. On the basis of this model, future retweeting trends can be predicted. Our experiments on data obtained from the Chinese micro-blogging website Sina Weibo show that the proposed model has lower predictive error compared to the four commonly used prediction methods.展开更多
In the paper, we concentrate on the infl uence of heterogeneity on the performance of forwarding algorithms under opportunistic networks. Therefore, we first describe two different heterogeneous network models, and ca...In the paper, we concentrate on the infl uence of heterogeneity on the performance of forwarding algorithms under opportunistic networks. Therefore, we first describe two different heterogeneous network models, and capture the heterogeneity which concern mobile nodes' contact dynamics under the individual models and the spatial models. Then we investigate inter-contact time is not fully follow exponential distribution and compare the performance of the delivery delay between direct forwarding protocol and three-hop forwarding protocol under three network models. We illustrate the performance of message delivery delay under the spray and wait protocol and prophet protocol from simulation results. Our simulation results show that the heterogeneity should be considered for the performance of forwarding protocols.展开更多
Although VEGFR-3 deficiency disrupts blood vascular development during early embryogenesis, the underlying mechanism was not clear. To characterize its function in angiogenesis and lymphangiogenesis, we employed two g...Although VEGFR-3 deficiency disrupts blood vascular development during early embryogenesis, the underlying mechanism was not clear. To characterize its function in angiogenesis and lymphangiogenesis, we employed two genetically modified mouse models in this study, targeting the coding region for the ligand-binding domain （Vegfr△LBD） or the tyrosine kinase domain with an inactivation point mutation （Vegfr3^TKmat）. We show that lymphatic growth was disrupted in Vegfr3△LBD/△LBD and Vegfr3^TKmut3^TKmat mice, but blood vessels developed normally in both embryo and yolk sac. Interestingly, in Vegfr3△LBD/△LBD but not Vegfr3^TKmut3^TKmat mice, lymph sac was present but there was lack of iym- phangiogenic sprouting. We further demonstrate that both the wild-type and mutant forms of VEGFR-3 could form heterodimers with VEGFR-2, and decreased the level of phospho-VEGFR-2 and the downstream phospho-Erk1/2 in endothelial cells when they were treated with VEGF-A. These findings indicate that signaling mediated via VEGFR-3 activation by its cognate ligands （VEGF-C/-D） is not required for angiogenesis, and that VEGFR-3 may play a role in this process by modulating VEGFR-2-mediated signals.展开更多
基金supported by National Natural Science Foundation of China under Grants No. 60773156, No. 61073004Chinese Major State Basic Research Development 973 Program under Grant No. 2011CB302203-2Important National Science &Technology Specific Program under Grant No. 2011ZX01042001-002-2
文摘Microblogs currently play an important role in social communication. Hot topics currently being tweeted can quickly become popular within a very short time as a result of retweeting. Gaining an understanding of the retweeting behavior is desirable for a number of tasks such as topic detection, personalized message recommendation, and fake information monitoring and prevention. Interestingly, the propagation of tweets bears some similarity to the spread of infectious diseases. We present a method to model the tweets' spread behavior in microblogs based on the classic Susceptible-Infectious-Susceptible (SIS) epidemic model that was developed in the medical field for the spread of infectious diseases. On the basis of this model, future retweeting trends can be predicted. Our experiments on data obtained from the Chinese micro-blogging website Sina Weibo show that the proposed model has lower predictive error compared to the four commonly used prediction methods.
基金supported by the National Natural Science Foundation of China under Grant No.61171097
文摘In the paper, we concentrate on the infl uence of heterogeneity on the performance of forwarding algorithms under opportunistic networks. Therefore, we first describe two different heterogeneous network models, and capture the heterogeneity which concern mobile nodes' contact dynamics under the individual models and the spatial models. Then we investigate inter-contact time is not fully follow exponential distribution and compare the performance of the delivery delay between direct forwarding protocol and three-hop forwarding protocol under three network models. We illustrate the performance of message delivery delay under the spray and wait protocol and prophet protocol from simulation results. Our simulation results show that the heterogeneity should be considered for the performance of forwarding protocols.
基金Acknowledgments We thank Dr Lena Claesson-Welsh （Uppsala University）, and PIs of Model Animal Research Center （MARC, Nanjing University） for the helpful discussion about the work, and Yanlan Cao, Wenting Shi and all the staff in the MARC Animal facility of Nanjing University for excellent technical assistance. This work wasfinancially supported by grants from the National Natural Science Foundation of China （30771069, 30671038, and 30930028）, the Ministry of Science and Technology of China （2006CB943500）, and the Ministry of Education of China （NCET： Program for New Century Excellent Talents in University）.
文摘Although VEGFR-3 deficiency disrupts blood vascular development during early embryogenesis, the underlying mechanism was not clear. To characterize its function in angiogenesis and lymphangiogenesis, we employed two genetically modified mouse models in this study, targeting the coding region for the ligand-binding domain （Vegfr△LBD） or the tyrosine kinase domain with an inactivation point mutation （Vegfr3^TKmat）. We show that lymphatic growth was disrupted in Vegfr3△LBD/△LBD and Vegfr3^TKmut3^TKmat mice, but blood vessels developed normally in both embryo and yolk sac. Interestingly, in Vegfr3△LBD/△LBD but not Vegfr3^TKmut3^TKmat mice, lymph sac was present but there was lack of iym- phangiogenic sprouting. We further demonstrate that both the wild-type and mutant forms of VEGFR-3 could form heterodimers with VEGFR-2, and decreased the level of phospho-VEGFR-2 and the downstream phospho-Erk1/2 in endothelial cells when they were treated with VEGF-A. These findings indicate that signaling mediated via VEGFR-3 activation by its cognate ligands （VEGF-C/-D） is not required for angiogenesis, and that VEGFR-3 may play a role in this process by modulating VEGFR-2-mediated signals.
