A novel structure of spot size converter is designed to allow low loss and large alignment tolerance between single mode rib waveguide devices and fiber arrays theoretically.The spot size converter consists of a ta...A novel structure of spot size converter is designed to allow low loss and large alignment tolerance between single mode rib waveguide devices and fiber arrays theoretically.The spot size converter consists of a tapered rib core region and a double cladding region.Through optimizing parameters,an expanded mode field can be tightly confined in the inner cladding and thus radiation loss be reduced largely at the tapered region.The influence of refractive index and thickness of the inner cladding on coupling loss is analyzed in particular.A novel,easy method of fabricating tapered rib spot size converter based on silicon on insulator material is proposed.展开更多
The wear behavior and mild−severe(M−S)wear transition of Mg−10Gd−1.5Y−0.4Zr alloy were investigated within a temperature range of 20−200℃.The morphologies and compositions of worn surfaces were examined to identify t...The wear behavior and mild−severe(M−S)wear transition of Mg−10Gd−1.5Y−0.4Zr alloy were investigated within a temperature range of 20−200℃.The morphologies and compositions of worn surfaces were examined to identify the wear mechanisms using scanning electron microscope and energy dispersive X-ray spectrometer.The microstructure and hardness in the subsurfaces were analyzed to reveal the M−S wear transition mechanism.Under a constant loads of 20,35 and 40 N,each wear rate−test temperature curve presented a turning point which corresponded to the M−S wear transition.In mild wear,the surface material was plastically deformed and hence was strainhardened,whereas in severe wear,the surface material was dynamically recrystallized and consequently was softened.It has been found that the critical temperature for M−S wear transition decreases with increasing the normal load,and the normal load exhibits an almost linear relationship with critical temperature for M−S wear transition.This work reveals that the M−S wear transition of the studied alloy conforms to the surface DRX temperature criterion.展开更多
The torsional fretting wear tests of 7075 aluminum alloy flat against 52100 steel ball in dry condition were carried out on a new high-precision torsional fretting-wear tester.The kinetics behaviors and damage mechani...The torsional fretting wear tests of 7075 aluminum alloy flat against 52100 steel ball in dry condition were carried out on a new high-precision torsional fretting-wear tester.The kinetics behaviors and damage mechanism of 7075 aluminum alloy under different angular displacement amplitudes were investigated in detail.The results show that the torsional fretting running behaviors of 7075 aluminum alloy can be defined by three fretting regimes(i.e.partial slip regime(PSR),mixed fretting regime(MFR) and slip regime(SR)) with the increase of angular displacement amplitudes.In PSR,the damage occurs at the lateral portion of the contact zone with a slight annular shape.However,in MFR and SR,more severe damages are observed and the debris layer covers the wear scars.Friction torque and dissipation energy which are strongly dependent upon the imposed angular displacement amplitudes and presented in three stages were discussed in detail.The mechanisms of torsional fretting wear of aluminum alloy are mainly oxidative wear,abrasive wear and delamination in the three fretting regimes.In addition,the oxidative debris plays an important role during the torsional fretting wear processes.展开更多
The tumor suppressor p53 is a multifunctional, highly regulated, and promoter-specific transcriptional factor that is uniquely sensitive to DNA damage and cellular stress signaling. The mechanisms by which p53 directs...The tumor suppressor p53 is a multifunctional, highly regulated, and promoter-specific transcriptional factor that is uniquely sensitive to DNA damage and cellular stress signaling. The mechanisms by which p53 directs a damaged cell down either a cell growth arrest or an apoptotic pathway remain poorly understood. Evidence suggests that the in vivo functions of p53 seem to balance the cell-fate choice with the type and severity of damage that occurs. The concept of antirepression, or inhibition of factors that normally keep p53 at bay, may help explain the physiological mechanisms for p53 activation. These factors also provide novel chemotherapeutic targets for the reactivation of p53 in tumors harboring a wild-type copy of the gene.展开更多
AIM: To identify the proportion, causes and the nature of drug-induced liver injury (DILI) in patients with no- tably elevated alanine aminotransferase (ALT). METHODS: All the inpatients with ALT levels above 10...AIM: To identify the proportion, causes and the nature of drug-induced liver injury (DILI) in patients with no- tably elevated alanine aminotransferase (ALT). METHODS: All the inpatients with ALT levels above 10 times upper limit of normal range (ULN) were ret- rospectively identified from a computerized clinical laboratory database at our hospital covering a 12-mo period. Relevant clinical information was obtained from medical records. Alternative causes of ALT eleva- tions were examined for each patient, including bili- ary abnormality, viral hepatitis, hemodynamic injury, malignancy, DILI or undetermined and other causes. All suspected DILI cases were causality assessed usingthe Council for International Organizations of Medical Sciences scale, and only the cases classified as highly probable, probable, or possible were diagnosed as DILI. Comments related to the diagnosis of DILI in the medical record and in the discharge letter for each case were also examined to evaluate DILI detection by the treating doctors. RESULTS: A total of 129 cases with ALT 〉 i0 ULN were identified. Hemodynamic injury (n = 46, 35.7%), DILl (n = 25, 19.4%) and malignancy (n = 21, 16.3%) were the top three causes of liver injury. Peak ALT val- ues were lower in DILI patients than in patients with hemodynamic injury (14.5 5.6 ULN vs 32.5 :I: 30.7 ULN, P = 0.001). Among DILI patients, one (4%) case was classified as definite, 19 (76%) cases were clas- sified as probable and 5 (20%) as possible according to the ClOMS scale. A hepatocellular pattern was ob- served in 23 (92%) cases and mixed in 2 (8%). The extent of severity of liver injury was mild in 21 (84%) patients and moderate in 4 (16%). Before discharge, 10 (40%) patients were recovered and the other 15 (60%) were improved. The improved patients tended to have a higher peak ALT (808 + 348 U/L vs 623 + 118 U/L, P = 0.016) and shorter treatment duration before discharge (8 + 6 d vs 28 ~ 12 d, P = 0.008) compared with the recovered patients. Twenty-two drugs and 6 herbs were found associated with DILl. Antibacterials were the most common agents causing DILI in 8 (32%) cases, followed by glucocorticoids in 6 (24%) cases. Twenty-four (96%) cases received treatment of DILl with at least one adjunctive drug. Agents for treatment of DILI included anti-inflammatory drugs (e.g., glycyr- rhizinate), antioxidants (e.g., glutathione, ademetionine 1,4-butanedisulfonate and tiopronin), polyene phospha- tidyl choline and herbal extracts (e.g., protoporphyrin disodium and silymarin). Diagnosis of DILl was not mentioned in the discharge letter in 60% of the cases. Relative to prevalent cases and cases from wards of internal medicine, incident cases and cases from surgi- cal wards had a higher risk of missed diagnosis in dis- charge letter [odds ratio (OR) 32.7, 95%CI (2.8-374.1),CONCLUSION: DILI is mostly caused by use of anti- bacterials and glucocorticoids, and constitutes about one fifth of hospitalized patients with ALT 〉 10 ULN. DILI is underdiagnosed frequently.展开更多
To locate and quantify local damage in a simply supported bridge, in this study, we derived a rotational-angle influence line equation of a simply supported beam model with local damage. Using the diagram multiplicati...To locate and quantify local damage in a simply supported bridge, in this study, we derived a rotational-angle influence line equation of a simply supported beam model with local damage. Using the diagram multiplication method, we introduce an analytical formula for a novel damage-identification indicator, namely the diff erence of rotational-angle influence linescurvature(DRAIL-C). If the initial stiff ness of the simply supported beam is known, the analytical formula can be effectively used to determine the extent of damage under certain circumstances. We determined the effectiveness and anti-noise performance of this new damage-identification method using numerical examples of a simply supported beam, a simply supported hollow-slab bridge, and a simply supported truss bridge. The results show that the DRAIL-C is directly proportional to the moving concentrated load and inversely proportional to the distance between the bridge support and the concentrated load and the distance between the damaged truss girder and the angle measuring points. The DRAIL-C indicator is more sensitive to the damage in a steel-truss-bridge bottom chord than it is to the other elements.展开更多
Background Development of arterial dissection is thought to be an important key factor for bailout stenting in femoropopliteal disease. We aimed to evaluate the difference in dissection rate and outcomes between the t...Background Development of arterial dissection is thought to be an important key factor for bailout stenting in femoropopliteal disease. We aimed to evaluate the difference in dissection rate and outcomes between the treatment group with rotational atherectomy and with?out it. Methods From January 2011 to October 2016, we compared the angiography after balloon angioplasty (BA) of de-novo, femoropop?liteal, steno-occlusive lesions whether they were treated by rotational atherectomy prior to the BA or not. Fifty-nine lesions (8 occlusions; 3 involving popliteal segment; lesion length: 86.3 ± 66.8 mm) in 44 patients (29 males; mean age 66.9 ± 9.7 years) were enrolled for this review. Results Forty-two lesions were treated using rotational atherectomy, prior to BA while 17 were recanalized firstly by BA. Clinical and lesion characteristics were not different between the groups. However, the rate of significant arterial dissection (type C to F) was lower in the atherectomy group (88.2% vs. 42.9%; P = 0.001). In multivariate analysis, use of the atherectomy device was the only risk factor for prevention of development of significant dissection (P = 0.013; OR = 0.12; 95% CI: 0.025?0.642). Patients were treated either by the angioplasty alone, drug coated balloon or stent insertion. There was lower trend in target vessel revascularization and primary patency toward the atherectomy group (low rank P = 0.108 and 0.166), however secondary patency was significantly better (low rank P = 0.001). Conclusions Rotational atherec?tomy before BA reduced the rate of significant dissection and therefore, might be a valuable option for minimizing need of bailout stenting.展开更多
The wear rate between the rotors of a hypotrochoidal gear pump is characterized.Using the knowledge of shape design on the rotors,the contact stresses without hydrodynamic effect between the rotor teeth were evaluated...The wear rate between the rotors of a hypotrochoidal gear pump is characterized.Using the knowledge of shape design on the rotors,the contact stresses without hydrodynamic effect between the rotor teeth were evaluated through the calculation of the Hertzian contact stress.Based on the above results and the sliding velocity between the rotors,a genetic algorithm (GA) was used as an optimization technique forminimizing the wear rate proportional factor (WRPF).The result shows that the wear rate or the WRPF can be reduced considerably,e.g.approximately 12.8%,throughout the optimization using GA.展开更多
文摘A novel structure of spot size converter is designed to allow low loss and large alignment tolerance between single mode rib waveguide devices and fiber arrays theoretically.The spot size converter consists of a tapered rib core region and a double cladding region.Through optimizing parameters,an expanded mode field can be tightly confined in the inner cladding and thus radiation loss be reduced largely at the tapered region.The influence of refractive index and thickness of the inner cladding on coupling loss is analyzed in particular.A novel,easy method of fabricating tapered rib spot size converter based on silicon on insulator material is proposed.
基金financial support from the National Natural Science Foundation of China (No.51775226)。
文摘The wear behavior and mild−severe(M−S)wear transition of Mg−10Gd−1.5Y−0.4Zr alloy were investigated within a temperature range of 20−200℃.The morphologies and compositions of worn surfaces were examined to identify the wear mechanisms using scanning electron microscope and energy dispersive X-ray spectrometer.The microstructure and hardness in the subsurfaces were analyzed to reveal the M−S wear transition mechanism.Under a constant loads of 20,35 and 40 N,each wear rate−test temperature curve presented a turning point which corresponded to the M−S wear transition.In mild wear,the surface material was plastically deformed and hence was strainhardened,whereas in severe wear,the surface material was dynamically recrystallized and consequently was softened.It has been found that the critical temperature for M−S wear transition decreases with increasing the normal load,and the normal load exhibits an almost linear relationship with critical temperature for M−S wear transition.This work reveals that the M−S wear transition of the studied alloy conforms to the surface DRX temperature criterion.
基金Project(2007CB714704) supported by the National Basic Research Program of ChinaProjects(50775192,50821063) supported by the National Natural Science Foundation of China
文摘The torsional fretting wear tests of 7075 aluminum alloy flat against 52100 steel ball in dry condition were carried out on a new high-precision torsional fretting-wear tester.The kinetics behaviors and damage mechanism of 7075 aluminum alloy under different angular displacement amplitudes were investigated in detail.The results show that the torsional fretting running behaviors of 7075 aluminum alloy can be defined by three fretting regimes(i.e.partial slip regime(PSR),mixed fretting regime(MFR) and slip regime(SR)) with the increase of angular displacement amplitudes.In PSR,the damage occurs at the lateral portion of the contact zone with a slight annular shape.However,in MFR and SR,more severe damages are observed and the debris layer covers the wear scars.Friction torque and dissipation energy which are strongly dependent upon the imposed angular displacement amplitudes and presented in three stages were discussed in detail.The mechanisms of torsional fretting wear of aluminum alloy are mainly oxidative wear,abrasive wear and delamination in the three fretting regimes.In addition,the oxidative debris plays an important role during the torsional fretting wear processes.
文摘The tumor suppressor p53 is a multifunctional, highly regulated, and promoter-specific transcriptional factor that is uniquely sensitive to DNA damage and cellular stress signaling. The mechanisms by which p53 directs a damaged cell down either a cell growth arrest or an apoptotic pathway remain poorly understood. Evidence suggests that the in vivo functions of p53 seem to balance the cell-fate choice with the type and severity of damage that occurs. The concept of antirepression, or inhibition of factors that normally keep p53 at bay, may help explain the physiological mechanisms for p53 activation. These factors also provide novel chemotherapeutic targets for the reactivation of p53 in tumors harboring a wild-type copy of the gene.
基金Supported by Zhejiang Provincial Bureau of Education,No.200908690Zhejiang Provincial Bureau of Health,No.2012KYA090
文摘AIM: To identify the proportion, causes and the nature of drug-induced liver injury (DILI) in patients with no- tably elevated alanine aminotransferase (ALT). METHODS: All the inpatients with ALT levels above 10 times upper limit of normal range (ULN) were ret- rospectively identified from a computerized clinical laboratory database at our hospital covering a 12-mo period. Relevant clinical information was obtained from medical records. Alternative causes of ALT eleva- tions were examined for each patient, including bili- ary abnormality, viral hepatitis, hemodynamic injury, malignancy, DILI or undetermined and other causes. All suspected DILI cases were causality assessed usingthe Council for International Organizations of Medical Sciences scale, and only the cases classified as highly probable, probable, or possible were diagnosed as DILI. Comments related to the diagnosis of DILI in the medical record and in the discharge letter for each case were also examined to evaluate DILI detection by the treating doctors. RESULTS: A total of 129 cases with ALT 〉 i0 ULN were identified. Hemodynamic injury (n = 46, 35.7%), DILl (n = 25, 19.4%) and malignancy (n = 21, 16.3%) were the top three causes of liver injury. Peak ALT val- ues were lower in DILI patients than in patients with hemodynamic injury (14.5 5.6 ULN vs 32.5 :I: 30.7 ULN, P = 0.001). Among DILI patients, one (4%) case was classified as definite, 19 (76%) cases were clas- sified as probable and 5 (20%) as possible according to the ClOMS scale. A hepatocellular pattern was ob- served in 23 (92%) cases and mixed in 2 (8%). The extent of severity of liver injury was mild in 21 (84%) patients and moderate in 4 (16%). Before discharge, 10 (40%) patients were recovered and the other 15 (60%) were improved. The improved patients tended to have a higher peak ALT (808 + 348 U/L vs 623 + 118 U/L, P = 0.016) and shorter treatment duration before discharge (8 + 6 d vs 28 ~ 12 d, P = 0.008) compared with the recovered patients. Twenty-two drugs and 6 herbs were found associated with DILl. Antibacterials were the most common agents causing DILI in 8 (32%) cases, followed by glucocorticoids in 6 (24%) cases. Twenty-four (96%) cases received treatment of DILl with at least one adjunctive drug. Agents for treatment of DILI included anti-inflammatory drugs (e.g., glycyr- rhizinate), antioxidants (e.g., glutathione, ademetionine 1,4-butanedisulfonate and tiopronin), polyene phospha- tidyl choline and herbal extracts (e.g., protoporphyrin disodium and silymarin). Diagnosis of DILl was not mentioned in the discharge letter in 60% of the cases. Relative to prevalent cases and cases from wards of internal medicine, incident cases and cases from surgi- cal wards had a higher risk of missed diagnosis in dis- charge letter [odds ratio (OR) 32.7, 95%CI (2.8-374.1),CONCLUSION: DILI is mostly caused by use of anti- bacterials and glucocorticoids, and constitutes about one fifth of hospitalized patients with ALT 〉 10 ULN. DILI is underdiagnosed frequently.
基金supported by the National Natural Science Foundation of China(Nos.51608245 and 51568041)Natural Science Foundation of Gansu Province(Nos.148RJZA026 and 2014GS02269)
文摘To locate and quantify local damage in a simply supported bridge, in this study, we derived a rotational-angle influence line equation of a simply supported beam model with local damage. Using the diagram multiplication method, we introduce an analytical formula for a novel damage-identification indicator, namely the diff erence of rotational-angle influence linescurvature(DRAIL-C). If the initial stiff ness of the simply supported beam is known, the analytical formula can be effectively used to determine the extent of damage under certain circumstances. We determined the effectiveness and anti-noise performance of this new damage-identification method using numerical examples of a simply supported beam, a simply supported hollow-slab bridge, and a simply supported truss bridge. The results show that the DRAIL-C is directly proportional to the moving concentrated load and inversely proportional to the distance between the bridge support and the concentrated load and the distance between the damaged truss girder and the angle measuring points. The DRAIL-C indicator is more sensitive to the damage in a steel-truss-bridge bottom chord than it is to the other elements.
文摘Background Development of arterial dissection is thought to be an important key factor for bailout stenting in femoropopliteal disease. We aimed to evaluate the difference in dissection rate and outcomes between the treatment group with rotational atherectomy and with?out it. Methods From January 2011 to October 2016, we compared the angiography after balloon angioplasty (BA) of de-novo, femoropop?liteal, steno-occlusive lesions whether they were treated by rotational atherectomy prior to the BA or not. Fifty-nine lesions (8 occlusions; 3 involving popliteal segment; lesion length: 86.3 ± 66.8 mm) in 44 patients (29 males; mean age 66.9 ± 9.7 years) were enrolled for this review. Results Forty-two lesions were treated using rotational atherectomy, prior to BA while 17 were recanalized firstly by BA. Clinical and lesion characteristics were not different between the groups. However, the rate of significant arterial dissection (type C to F) was lower in the atherectomy group (88.2% vs. 42.9%; P = 0.001). In multivariate analysis, use of the atherectomy device was the only risk factor for prevention of development of significant dissection (P = 0.013; OR = 0.12; 95% CI: 0.025?0.642). Patients were treated either by the angioplasty alone, drug coated balloon or stent insertion. There was lower trend in target vessel revascularization and primary patency toward the atherectomy group (low rank P = 0.108 and 0.166), however secondary patency was significantly better (low rank P = 0.001). Conclusions Rotational atherec?tomy before BA reduced the rate of significant dissection and therefore, might be a valuable option for minimizing need of bailout stenting.
基金supported by Changwon National University in 2010,Korea
文摘The wear rate between the rotors of a hypotrochoidal gear pump is characterized.Using the knowledge of shape design on the rotors,the contact stresses without hydrodynamic effect between the rotor teeth were evaluated through the calculation of the Hertzian contact stress.Based on the above results and the sliding velocity between the rotors,a genetic algorithm (GA) was used as an optimization technique forminimizing the wear rate proportional factor (WRPF).The result shows that the wear rate or the WRPF can be reduced considerably,e.g.approximately 12.8%,throughout the optimization using GA.