建立热转换元素分析-同位素比质谱联用(thermal conversion/elemental analysis-isotope ratio mass spectrometry,TC/EA-IRMS)检测低氘水中氘含量分析方法,用于低氘包装饮用水中氘含量的监督检测。水样采用0.22μm微孔滤膜过滤样品适量...建立热转换元素分析-同位素比质谱联用(thermal conversion/elemental analysis-isotope ratio mass spectrometry,TC/EA-IRMS)检测低氘水中氘含量分析方法,用于低氘包装饮用水中氘含量的监督检测。水样采用0.22μm微孔滤膜过滤样品适量,移取2 mL水样装满进样瓶,进样量0.1μL,反应炉温度1380℃,柱温箱温度85℃,载气He流速100 mL/min,每个水样进行4~6次分析。测试样品瓶不留顶空和剔除第1个数据点可以避免样品瓶顶空体积和记忆效应对δ2H测定值的影响,从而提高计算得到的氘含量值的精度。该方法适用于12.624~155.760μg/g范围内水中氘含量的测定,测量值与理论值的相对标准偏差低于0.6%。对同一低氘水样连续8次测定值除第1个点后氘含量标准偏差(standard deviation,SD)为0.08μg/g,30 d内分3次测定同一低氘水样氘含量SD为0.086μg/g,重复性和再现性好。不同仪器方法测定的低氘水样SD低于1μg/g。检测8个市售低氘包装饮用水,测定值和标识值不相符的现象明显。TC/EA-IRMS测定低氘水中氘含量分析方法可以为标识为低氘水的包装饮用水中氘含量的监管检测提供技术支撑和理论依据。展开更多
A rearrangeable nonblocking silicon-on-insulator-based thermo-optic 4x4 switch matrix with spot size converters （SSCs） and a new driving circuit are designed and fabricated. The introduction of a spot size converter...A rearrangeable nonblocking silicon-on-insulator-based thermo-optic 4x4 switch matrix with spot size converters （SSCs） and a new driving circuit are designed and fabricated. The introduction of a spot size converter （SSC） has decreased the insertion loss to less than 10dB and the new driving circuit has improved the response speed to less than l^s.展开更多
The ACE （angiotensin converting enzyme） inhibitors are not only drugs widely prescribed drugs in cardiovascular diseases, but also potentially therapeutic agents in dementia. Based on the findings that the ACE inhib...The ACE （angiotensin converting enzyme） inhibitors are not only drugs widely prescribed drugs in cardiovascular diseases, but also potentially therapeutic agents in dementia. Based on the findings that the ACE inhibitors could activate the c-Jun N-terminal kinase signal to increase the ACE gene expression and that the Alu element of the human ACE gene involved in regulating ACE promoter activity, we aimed to investigate whether there are different pharmacogenetic responses of ACE I/D polymorphism to the ACE inhibitors in neurons. The three reporter vectors, pACEpro（0-SEAP, p-I-ACEpro-SEAP, and p-D-ACEpro-SEAP were used to examine the transcriptional activity of the vectors responding to the lisinopril treatment using a transient-transfection method in SH-SY5Y cells. Our results showed that lisinopril increased the promoter activity of an ACE gene by 16.7%. Additionally, we found the lisinopril enhanced the ACE promoter activity of the I-form vector by 17.2%, but adversely reduced that of the D-form vector by 16.8%, as compared with the respective control without the lisinopril treatment. Firstly, our findings had proved that the UD polymorphism of ACE gene contrarily responds to the ACE inhibitors in regulating the ACE expression in neurons, which provide a novel insight suggesting genetic testing to tailor the treatment regimens in AD （Alzheimer＇s disease） patients.展开更多
This study relies on a contrastive analysis to underscore the functions of stress as a shift in translation, especially when phonological specifications can have an impact on translation. In the original model of tran...This study relies on a contrastive analysis to underscore the functions of stress as a shift in translation, especially when phonological specifications can have an impact on translation. In the original model of translation shifts proposed by Catford, only segmental linguistic elements are taken into consideration, while the model totally ignores stress as a supra-segmental linguistic element. Including stress within the analytic procedures of the model can bring about a new type of shift. This implies that Catford＇s categorization of shifts must be developed in order to increase its applicability, especially when phonological specifications in the source text can have an impact on grammar and lexical items in the target text. As a result of the inclusion of stress into Catford＇s original mode, a revised version of the translation shift model is suggested. The study further emphasizes the various dimensions of stress and the functions it can have in oral aspects of translation and drama translation.展开更多
文摘建立热转换元素分析-同位素比质谱联用(thermal conversion/elemental analysis-isotope ratio mass spectrometry,TC/EA-IRMS)检测低氘水中氘含量分析方法,用于低氘包装饮用水中氘含量的监督检测。水样采用0.22μm微孔滤膜过滤样品适量,移取2 mL水样装满进样瓶,进样量0.1μL,反应炉温度1380℃,柱温箱温度85℃,载气He流速100 mL/min,每个水样进行4~6次分析。测试样品瓶不留顶空和剔除第1个数据点可以避免样品瓶顶空体积和记忆效应对δ2H测定值的影响,从而提高计算得到的氘含量值的精度。该方法适用于12.624~155.760μg/g范围内水中氘含量的测定,测量值与理论值的相对标准偏差低于0.6%。对同一低氘水样连续8次测定值除第1个点后氘含量标准偏差(standard deviation,SD)为0.08μg/g,30 d内分3次测定同一低氘水样氘含量SD为0.086μg/g,重复性和再现性好。不同仪器方法测定的低氘水样SD低于1μg/g。检测8个市售低氘包装饮用水,测定值和标识值不相符的现象明显。TC/EA-IRMS测定低氘水中氘含量分析方法可以为标识为低氘水的包装饮用水中氘含量的监管检测提供技术支撑和理论依据。
基金Supported in part by the National Key Basic Research Special Foundation of China under Grant No. G2000-03-66the Na-tional High Technology Program of China under Grant No.2002AA312060the National Natural Science Foundation ofChina under Grant No. 60336010.
文摘A rearrangeable nonblocking silicon-on-insulator-based thermo-optic 4x4 switch matrix with spot size converters （SSCs） and a new driving circuit are designed and fabricated. The introduction of a spot size converter （SSC） has decreased the insertion loss to less than 10dB and the new driving circuit has improved the response speed to less than l^s.
文摘The ACE （angiotensin converting enzyme） inhibitors are not only drugs widely prescribed drugs in cardiovascular diseases, but also potentially therapeutic agents in dementia. Based on the findings that the ACE inhibitors could activate the c-Jun N-terminal kinase signal to increase the ACE gene expression and that the Alu element of the human ACE gene involved in regulating ACE promoter activity, we aimed to investigate whether there are different pharmacogenetic responses of ACE I/D polymorphism to the ACE inhibitors in neurons. The three reporter vectors, pACEpro（0-SEAP, p-I-ACEpro-SEAP, and p-D-ACEpro-SEAP were used to examine the transcriptional activity of the vectors responding to the lisinopril treatment using a transient-transfection method in SH-SY5Y cells. Our results showed that lisinopril increased the promoter activity of an ACE gene by 16.7%. Additionally, we found the lisinopril enhanced the ACE promoter activity of the I-form vector by 17.2%, but adversely reduced that of the D-form vector by 16.8%, as compared with the respective control without the lisinopril treatment. Firstly, our findings had proved that the UD polymorphism of ACE gene contrarily responds to the ACE inhibitors in regulating the ACE expression in neurons, which provide a novel insight suggesting genetic testing to tailor the treatment regimens in AD （Alzheimer＇s disease） patients.
文摘This study relies on a contrastive analysis to underscore the functions of stress as a shift in translation, especially when phonological specifications can have an impact on translation. In the original model of translation shifts proposed by Catford, only segmental linguistic elements are taken into consideration, while the model totally ignores stress as a supra-segmental linguistic element. Including stress within the analytic procedures of the model can bring about a new type of shift. This implies that Catford＇s categorization of shifts must be developed in order to increase its applicability, especially when phonological specifications in the source text can have an impact on grammar and lexical items in the target text. As a result of the inclusion of stress into Catford＇s original mode, a revised version of the translation shift model is suggested. The study further emphasizes the various dimensions of stress and the functions it can have in oral aspects of translation and drama translation.
