We report on a case of disseminated peritoneal leiomyomatosis (LPD). Disseminated peritoneal fibroids are a very rare medical condition, only up to 50 cases can be found in the international literature. Our patient, a...We report on a case of disseminated peritoneal leiomyomatosis (LPD). Disseminated peritoneal fibroids are a very rare medical condition, only up to 50 cases can be found in the international literature. Our patient, a 48-year-old caucasian woman, complained of right sided pelvic pain. Her medical history included vaginal hysterectomy for dysmenorrhea six years before. She had a BMI of 30 and had never used hormonal contraceptives. Sonography revealed multiple small tumors in the pelvis and some free fluid in the abdominal cavity. CA 125 was elevated, which led to the presumptive diagnosis of ovarian cancer. Intraoperatively, we found disseminated leiomyomas in the ovaries, greater omentum and the peritoneum which were resected. Histopathologic workup showed that the grade of proliferation of the fibroids was less than 1%. As this rare disease has a good prognosis without further treatment, no postoperative therapy was planned.展开更多
Loss of basement membrane(BM)components,such as type IV collagen has been demonstrated in ovarian cancer,but the associations with other mole cules like CD44v6,involved in metastatic process of ovarian carcinoma,have ...Loss of basement membrane(BM)components,such as type IV collagen has been demonstrated in ovarian cancer,but the associations with other mole cules like CD44v6,involved in metastatic process of ovarian carcinoma,have not been fully analyzed.This study i nvestigates the ex-pression of type IV collagen,CD44v6molecule in corre-lation with p53and Ki -67presence in primary and metastatic lesion of ovarian carcin oma to define their role in metastases of ovarian carcinoma.The expression of type IV collagen,CD44v6,p53,and Ki -67was evaluated on frozen tissue sections from primary ovarian tumors(malignant n =37,benign n =16),metastatic lesions(n =29)and ascitic fluid cells(n =28).Protein ex-pression of all studied biomarkersw as evaluated in a subset of specimens using immunohistochem istry(IHC).Type IV collagen expression in the primary o varian carcinoma was positively correlated with International Federation ofGyne-cology andObstetrics(FIGO)-stage and tumor grade.Significant difference was observe d for type IV collagen immunoreactivity in carcinoma cell s in effusions when compared to corresponding primary t umors(P<0.001)and metastatic lesions(P<0.001).Likewise downreg-ulation of type IV collagen expression was seen in pri-mary ovarian carcinomas(P =0.01),ascitic fluid cells(P<0.001),and metastases(P =0.003)when com-pared to benign ovarian neoplasms.CD44v6expression was detected in a comparable percentage of primary carcinomas(51%)and metastatic lesions(52%).In cells isolated from ascitic fluid,CD44v6immunopositivity was observed in 43%of cases.A comparative analysis of primary and metastatic tumors and carcinoma cells in effusion did not reveal differences in expression of CD44v6.Positivity of CD44v6was found in 2/16(12%)of benign ovarian neoplasms.There were no significan t differences between CD44v6expression in benign neoplasms compared to pri-mary malignant tumors and metastase s(P>0.05).CD44v6expression in primary ovaria n carcinomas was as-sociated with higher tumor grade(P =0.01)and histo-logical type of tumors(P =0.01).An inverse relation-ship of type IV collagen expression w ith p53and CD44v6positivity in benign and malignant ovarian tumors was found(P>0.01).Type IV collagen expression was inversely correlated with p53status(P =0.03)in metastatic le-sions.A slight trend toward an inverse correlation between Ki -67and type IV collagen expressio n was observed inboth benign and malignant ovarian tu mors and metastases.Our data suggest that observed inverse correlation of type IV collagen expression with p53,CD44v6,and slight with Ki -67positivity in primary benign a nd malignant tumors indicates that these molecules may c ooperate in the inva-sion and progression of ovarian carc inomas.展开更多
文摘We report on a case of disseminated peritoneal leiomyomatosis (LPD). Disseminated peritoneal fibroids are a very rare medical condition, only up to 50 cases can be found in the international literature. Our patient, a 48-year-old caucasian woman, complained of right sided pelvic pain. Her medical history included vaginal hysterectomy for dysmenorrhea six years before. She had a BMI of 30 and had never used hormonal contraceptives. Sonography revealed multiple small tumors in the pelvis and some free fluid in the abdominal cavity. CA 125 was elevated, which led to the presumptive diagnosis of ovarian cancer. Intraoperatively, we found disseminated leiomyomas in the ovaries, greater omentum and the peritoneum which were resected. Histopathologic workup showed that the grade of proliferation of the fibroids was less than 1%. As this rare disease has a good prognosis without further treatment, no postoperative therapy was planned.
文摘Loss of basement membrane(BM)components,such as type IV collagen has been demonstrated in ovarian cancer,but the associations with other mole cules like CD44v6,involved in metastatic process of ovarian carcinoma,have not been fully analyzed.This study i nvestigates the ex-pression of type IV collagen,CD44v6molecule in corre-lation with p53and Ki -67presence in primary and metastatic lesion of ovarian carcin oma to define their role in metastases of ovarian carcinoma.The expression of type IV collagen,CD44v6,p53,and Ki -67was evaluated on frozen tissue sections from primary ovarian tumors(malignant n =37,benign n =16),metastatic lesions(n =29)and ascitic fluid cells(n =28).Protein ex-pression of all studied biomarkersw as evaluated in a subset of specimens using immunohistochem istry(IHC).Type IV collagen expression in the primary o varian carcinoma was positively correlated with International Federation ofGyne-cology andObstetrics(FIGO)-stage and tumor grade.Significant difference was observe d for type IV collagen immunoreactivity in carcinoma cell s in effusions when compared to corresponding primary t umors(P<0.001)and metastatic lesions(P<0.001).Likewise downreg-ulation of type IV collagen expression was seen in pri-mary ovarian carcinomas(P =0.01),ascitic fluid cells(P<0.001),and metastases(P =0.003)when com-pared to benign ovarian neoplasms.CD44v6expression was detected in a comparable percentage of primary carcinomas(51%)and metastatic lesions(52%).In cells isolated from ascitic fluid,CD44v6immunopositivity was observed in 43%of cases.A comparative analysis of primary and metastatic tumors and carcinoma cells in effusion did not reveal differences in expression of CD44v6.Positivity of CD44v6was found in 2/16(12%)of benign ovarian neoplasms.There were no significan t differences between CD44v6expression in benign neoplasms compared to pri-mary malignant tumors and metastase s(P>0.05).CD44v6expression in primary ovaria n carcinomas was as-sociated with higher tumor grade(P =0.01)and histo-logical type of tumors(P =0.01).An inverse relation-ship of type IV collagen expression w ith p53and CD44v6positivity in benign and malignant ovarian tumors was found(P>0.01).Type IV collagen expression was inversely correlated with p53status(P =0.03)in metastatic le-sions.A slight trend toward an inverse correlation between Ki -67and type IV collagen expressio n was observed inboth benign and malignant ovarian tu mors and metastases.Our data suggest that observed inverse correlation of type IV collagen expression with p53,CD44v6,and slight with Ki -67positivity in primary benign a nd malignant tumors indicates that these molecules may c ooperate in the inva-sion and progression of ovarian carc inomas.
