AIM:To study the relative efficacy of cisapride, metoclopramide,domperidone,erythromycin and mosapride on gastric emptying(GE)and small intestinal transit(SIT) in morphine treated mice. METHODS:Phenol red marker meal ...AIM:To study the relative efficacy of cisapride, metoclopramide,domperidone,erythromycin and mosapride on gastric emptying(GE)and small intestinal transit(SIT) in morphine treated mice. METHODS:Phenol red marker meal was employed to estimate GE and SIT in Swiss albino mice of either sex.The groups included were control,morphine 1 mg/kg(s.c.15 rain before test meal)alone or with(45 rain before test meal p.o.)cisapride 10 mg/kg,metoclopramide 20 mg/kg, domperidone 20 mg/kg,erythromycin 6 mg/kg and mosapride 20 mg/kg. RESULTS:Cisapride,metoclopramide and mosapride were effective in enhancing gastric emptying significantly(P<0.001) whereas other prokinetic agents failed to do so in normal mice.Metoclopramide completely reversed morphine induced delay in gastric emptying followed by mosapride. Metoclopramide alone was effective when given to normal mice in increasing the SIT.Cisapride,though it did not show any significant effect on SIT in normal mice,was able to reverse morphine induced delay in SIT significantly(P<0.001) followed by metoclopramide and mosapride. CONCLUSION:Metoclopramide and cisapride are most effective in reversing morphine-induced delay in gastric emptying and small intestinal transit in mice respectively.展开更多
Ocean waves can directly drive WECs （wave energy converters） to perform two types of motion--reciprocating motion and unidirectional rotary motion. In general, the efficiency of a reciprocating WEC is strongly wave-...Ocean waves can directly drive WECs （wave energy converters） to perform two types of motion--reciprocating motion and unidirectional rotary motion. In general, the efficiency of a reciprocating WEC is strongly wave-frequency dependent, whereas the efficiency of a rotary WEC can be somewhat wave-frequency independent. To date, a huge majority of WEC technologies under development in industry belong to the reciprocating class, and only a few WEC concepts fall in the unidirectional rotary class. In the present work, a wave-driven rotor for unidirectional rotary motion was proposed and characterized. A numerical tool has been developed for characterization of the rotor＇s unidirectional rotary tendency. The tool included a wave model and a drag force model. Simple circular tubes were used as blades in a basic rotor design. This basic design demonstrated strong potential for unidirectional rotary motion at a proper rotor submersion level and under various wave conditions. Two improved designs were yielded from the basic design. In one improved design, the original circular tubes were replaced with cylindrical shells of semicircular cross section as new blades. In another design, the semicircular shells were further modified to become one-way foldable. The two improvements significantly enhanced the rotors＇ unidirectional rotary tendency in waves, which has been verified by numerical simulation. Broad ranges of wave parameters and the submersion level have been numerically explored on the two improved rotor designs in conjunction with dimensional analysis.展开更多
A screw drive in-pipe robot is promising inspection equipment for small pipes. However, most of the existing screw drive in-pipe robots have problems of motion interference and slipping inside curved or irregular pipe...A screw drive in-pipe robot is promising inspection equipment for small pipes. However, most of the existing screw drive in-pipe robots have problems of motion interference and slipping inside curved or irregular pipes. These problems result from the coupled relations among the steering motion, the motion speed and the load ability of the robot. In order to deal with the problems, the axiomatic design （AD） theory is applied to evaluate and analyze the existing designs. Then an uncoupled con- cept design based on the AD theory is proposed and the complete AD decomposition process is presented. After that, the pro- posed robot based on a tri-axial differential angle modulation mechanism is designed to realize the uncoupled concept. Finally, the uncoupled property is verified in a dynamics simulation system. The simulation results indicate that the mc tion speed, load ability and steering motion of the proposed robot can be adjusted individually compared with the robots taat have inclin- ing-angle-fixed rollers. Owing to the uncoupled design, the proposed robot can mechanically adapt to straight pipes and curved pipes with less roller slipping.展开更多
文摘AIM:To study the relative efficacy of cisapride, metoclopramide,domperidone,erythromycin and mosapride on gastric emptying(GE)and small intestinal transit(SIT) in morphine treated mice. METHODS:Phenol red marker meal was employed to estimate GE and SIT in Swiss albino mice of either sex.The groups included were control,morphine 1 mg/kg(s.c.15 rain before test meal)alone or with(45 rain before test meal p.o.)cisapride 10 mg/kg,metoclopramide 20 mg/kg, domperidone 20 mg/kg,erythromycin 6 mg/kg and mosapride 20 mg/kg. RESULTS:Cisapride,metoclopramide and mosapride were effective in enhancing gastric emptying significantly(P<0.001) whereas other prokinetic agents failed to do so in normal mice.Metoclopramide completely reversed morphine induced delay in gastric emptying followed by mosapride. Metoclopramide alone was effective when given to normal mice in increasing the SIT.Cisapride,though it did not show any significant effect on SIT in normal mice,was able to reverse morphine induced delay in SIT significantly(P<0.001) followed by metoclopramide and mosapride. CONCLUSION:Metoclopramide and cisapride are most effective in reversing morphine-induced delay in gastric emptying and small intestinal transit in mice respectively.
文摘Ocean waves can directly drive WECs （wave energy converters） to perform two types of motion--reciprocating motion and unidirectional rotary motion. In general, the efficiency of a reciprocating WEC is strongly wave-frequency dependent, whereas the efficiency of a rotary WEC can be somewhat wave-frequency independent. To date, a huge majority of WEC technologies under development in industry belong to the reciprocating class, and only a few WEC concepts fall in the unidirectional rotary class. In the present work, a wave-driven rotor for unidirectional rotary motion was proposed and characterized. A numerical tool has been developed for characterization of the rotor＇s unidirectional rotary tendency. The tool included a wave model and a drag force model. Simple circular tubes were used as blades in a basic rotor design. This basic design demonstrated strong potential for unidirectional rotary motion at a proper rotor submersion level and under various wave conditions. Two improved designs were yielded from the basic design. In one improved design, the original circular tubes were replaced with cylindrical shells of semicircular cross section as new blades. In another design, the semicircular shells were further modified to become one-way foldable. The two improvements significantly enhanced the rotors＇ unidirectional rotary tendency in waves, which has been verified by numerical simulation. Broad ranges of wave parameters and the submersion level have been numerically explored on the two improved rotor designs in conjunction with dimensional analysis.
基金supported by the National Natural Science Foundation of China(Grant No.61273345)
文摘A screw drive in-pipe robot is promising inspection equipment for small pipes. However, most of the existing screw drive in-pipe robots have problems of motion interference and slipping inside curved or irregular pipes. These problems result from the coupled relations among the steering motion, the motion speed and the load ability of the robot. In order to deal with the problems, the axiomatic design （AD） theory is applied to evaluate and analyze the existing designs. Then an uncoupled con- cept design based on the AD theory is proposed and the complete AD decomposition process is presented. After that, the pro- posed robot based on a tri-axial differential angle modulation mechanism is designed to realize the uncoupled concept. Finally, the uncoupled property is verified in a dynamics simulation system. The simulation results indicate that the mc tion speed, load ability and steering motion of the proposed robot can be adjusted individually compared with the robots taat have inclin- ing-angle-fixed rollers. Owing to the uncoupled design, the proposed robot can mechanically adapt to straight pipes and curved pipes with less roller slipping.
