生物大分子质谱电离技术的突破及核磁共振三维结构测定方法的建立——2002年诺贝尔化学奖简介

The progress of science is in part attributed to the development of new methodologies. The application of mass spectrometry (MS) and nuclear magnetic resonance (NMR) in the study of biological macromolecules is such a representative example, which is the subject of this year’s Nobel prize award in chemistry shared by three scientists. The works include the development of soft desorption ionization methods for mass spectrometric analysis of biological macromolecules and the development of NMR for determining the three-dimensional structure of biological macromolecules in solution. These developments revolutionized the analytical methods for biomolecules such as proteins and facilitate the study of biological macromolecules so much enough to have deep effects on the whole life sciences.

质谱和核磁共振成为研究生物大分子的重要方法——简介2002年诺贝尔化学奖得主的贡献

2002年诺贝尔化学奖授予了在质谱和核磁共振领域有杰出贡献的三位科学家。John B. Fenn和Koichi Tanaka发展了质谱鉴定生物大分子质量的方法,Kurt Wüthrich建立了核磁共振测定蛋白质分子溶液三维结构的方法。他们的研究成果是质谱和核磁共振方法发展的里程碑,极大地推动了这两种研究方法的进一步发展。如今,质谱和核磁共振已发展成为认识生物大分子的强劲的研究手段。