Purpose : To examine the microvascular changes in the retrobulbar optic nerve in idio-pathic intracranial hypertension (PTC).Methods: Both optic nerves from a 29-year-old man with a two year history of PTC were examin...Purpose : To examine the microvascular changes in the retrobulbar optic nerve in idio-pathic intracranial hypertension (PTC).Methods: Both optic nerves from a 29-year-old man with a two year history of PTC were examined histologically and morphometrically. A semi-automated image analysis system and paraphenylenediamine (PPD) stain were employed to resolve sufficiently the microvascular images for counts and measurement.Results: There were 150 vessels distributed in the optic nerves which revealed the following: The average lumen of the vessels in outer sectors were larger than those of the inner sector vessels (168. 17μm2vs. 46. 99μm2; p = 0. 0338;OD; and 251. 96μm2vs. 130.02μm2;p = 0.029;OS) while in the normal control optic nerve the outer and inner area lumens were reversed in size-differential, but this did not show a statistical difference. The thickness of the PTC optic nerve vessel walls in the outer sectors was also greater than that of the walls in the inner sectors (4. 95μm vs. 2. 67μm;展开更多
文摘Purpose : To examine the microvascular changes in the retrobulbar optic nerve in idio-pathic intracranial hypertension (PTC).Methods: Both optic nerves from a 29-year-old man with a two year history of PTC were examined histologically and morphometrically. A semi-automated image analysis system and paraphenylenediamine (PPD) stain were employed to resolve sufficiently the microvascular images for counts and measurement.Results: There were 150 vessels distributed in the optic nerves which revealed the following: The average lumen of the vessels in outer sectors were larger than those of the inner sector vessels (168. 17μm2vs. 46. 99μm2; p = 0. 0338;OD; and 251. 96μm2vs. 130.02μm2;p = 0.029;OS) while in the normal control optic nerve the outer and inner area lumens were reversed in size-differential, but this did not show a statistical difference. The thickness of the PTC optic nerve vessel walls in the outer sectors was also greater than that of the walls in the inner sectors (4. 95μm vs. 2. 67μm;
