Objectives:This study aimed to evaluate the effects of a 16-week creative expression intervention program(CrExp)on the event-related potential(ERP)and task reaction time in older individuals with mild cognitive impair...Objectives:This study aimed to evaluate the effects of a 16-week creative expression intervention program(CrExp)on the event-related potential(ERP)and task reaction time in older individuals with mild cognitive impairment(MCI).Methods:This study is a randomized controlled clinical trial conducted in the Memory Center of Fujian Provincial hospital.Thirty-six MCI patients were randomly distributed into two groups.One group underwent a 16-week creative expression program(CrExp,n=18)and the other performed as a control group(CG,n=18)by general social activities.The amplitude and latency of ERP-P300 from the central(Cz),parietal(Pz),frontal(Fz)cortices and task reaction time(RT)were assessed at baseline,postinterventi on,and 24-week follow-up.Results:The CrExp group showed greater differences than CG of P300 latency in Cz(F=4.37,P=0.015),Pz(F=2.78,P=0.009),Fz(F=6.45,P=0.031)brain area after 16 weeks of intervention and in Fz(F=3.23,P=0.028),Cz(F=3.79,P=0.024),and Pz(F=5.60,P=0.036)at 24 weeks follow-up.Also,we analyzed the task reaction time between two groups and found that a shorten reaction time at postintervention(F=4.47,P=0.011)and 24 weeks follow-up(F=3.12,P=0.007)in the CrExp group.However,there was no difference in P300 amplitude in either brain area between the two groups.Conclusion:The electrophysiological results of the creative expression cognitive therapy group were more obvious than those of the general cognitive therapy group,and the latency and task reaction time may be considered as supported parameters in diagnosing the effects during non-drug therapy intervention in clinical practice.展开更多
The LIVE （Late In-Vessel Phase Experiments） test program investigates in-vessel melt pool behaviour and cooling strategies for in-vessel corium retention during severe accidents in light water reactors （LWR）. The ...The LIVE （Late In-Vessel Phase Experiments） test program investigates in-vessel melt pool behaviour and cooling strategies for in-vessel corium retention during severe accidents in light water reactors （LWR）. The main part of the LIVE facility is a 1：5 scaled semi-spherical lower head of a typical pressurized water reactor. Up to now, LIVE experiments have been performed in different initial external cooling conditions, melt volumes and internal heat generations. At present the well-known simulant material KNO3-NaNO3 in non-eutectic composition （80 mole% KNO3-20 mole% NaNO3） and in eutectic composition （50 mole% KNO3- 50 mole% NaNO3） is used in the live program. The 3D heat flux distribution through vessel wall, melt pool temperature, crust thickness and the pool melt composition can be measured or determined. Extensive results have been obtained concerning the melt pool thermal hydraulic behaviour in transient and in steady state conditions.展开更多
基金supported by the Youth research project of Fujian Provincial Health Commission(No.2018-1-75)Joint Fund of Fujian Province Scientific and Technological Department(No.2018Y9102)+1 种基金Soft Science Project of Fujian Science and Technology Department(No.2019R0055)National Science Foundation of China(No.81571379).
文摘Objectives:This study aimed to evaluate the effects of a 16-week creative expression intervention program(CrExp)on the event-related potential(ERP)and task reaction time in older individuals with mild cognitive impairment(MCI).Methods:This study is a randomized controlled clinical trial conducted in the Memory Center of Fujian Provincial hospital.Thirty-six MCI patients were randomly distributed into two groups.One group underwent a 16-week creative expression program(CrExp,n=18)and the other performed as a control group(CG,n=18)by general social activities.The amplitude and latency of ERP-P300 from the central(Cz),parietal(Pz),frontal(Fz)cortices and task reaction time(RT)were assessed at baseline,postinterventi on,and 24-week follow-up.Results:The CrExp group showed greater differences than CG of P300 latency in Cz(F=4.37,P=0.015),Pz(F=2.78,P=0.009),Fz(F=6.45,P=0.031)brain area after 16 weeks of intervention and in Fz(F=3.23,P=0.028),Cz(F=3.79,P=0.024),and Pz(F=5.60,P=0.036)at 24 weeks follow-up.Also,we analyzed the task reaction time between two groups and found that a shorten reaction time at postintervention(F=4.47,P=0.011)and 24 weeks follow-up(F=3.12,P=0.007)in the CrExp group.However,there was no difference in P300 amplitude in either brain area between the two groups.Conclusion:The electrophysiological results of the creative expression cognitive therapy group were more obvious than those of the general cognitive therapy group,and the latency and task reaction time may be considered as supported parameters in diagnosing the effects during non-drug therapy intervention in clinical practice.
文摘The LIVE （Late In-Vessel Phase Experiments） test program investigates in-vessel melt pool behaviour and cooling strategies for in-vessel corium retention during severe accidents in light water reactors （LWR）. The main part of the LIVE facility is a 1：5 scaled semi-spherical lower head of a typical pressurized water reactor. Up to now, LIVE experiments have been performed in different initial external cooling conditions, melt volumes and internal heat generations. At present the well-known simulant material KNO3-NaNO3 in non-eutectic composition （80 mole% KNO3-20 mole% NaNO3） and in eutectic composition （50 mole% KNO3- 50 mole% NaNO3） is used in the live program. The 3D heat flux distribution through vessel wall, melt pool temperature, crust thickness and the pool melt composition can be measured or determined. Extensive results have been obtained concerning the melt pool thermal hydraulic behaviour in transient and in steady state conditions.
