A new partitioning methodology is presented to accelerate 130nm and beyond large scale alternating phase shift mask(Alt PSM) design flow.This method deals with granularity self adaptively.Phas...A new partitioning methodology is presented to accelerate 130nm and beyond large scale alternating phase shift mask(Alt PSM) design flow.This method deals with granularity self adaptively.Phase conflicts resolution approaches are described and strategies guaranteeing phase compatible during layout compaction are also discussed.An efficient CAD prototype for dark field Alt PSM based on these algorithms is implemented.The experimental results on several industry layouts show that the tool can successfully cope with the rapid growth of phase conflicts with good quality and satisfy lower resource consumption with different requirements of precision and speedup.展开更多
Objective:To observe the effect of scraping therapy(ST)on the immune balance of serum helper T(Th)1/Th2 cells in autologous nucleus pulposus transplantation non-compressive lumbar disc herniation(LDH)model rats,and ex...Objective:To observe the effect of scraping therapy(ST)on the immune balance of serum helper T(Th)1/Th2 cells in autologous nucleus pulposus transplantation non-compressive lumbar disc herniation(LDH)model rats,and explore the immune mechanism of ST in reducing LDH pain.Methods:Seventy-two male Sprague-Dawley(SD)rats were randomly divided into a model group,a sham operation group and a ST group,with 24 rats in each group.Autologous nucleus pulposus transplantation non-compressive LDH models were established in the model group and ST group,while the rats in the sham operation group underwent sham operation without model establishment.On the fifth day after the model was successfully prepared,rats in the ST group received ST,once every other day,3 times as a course for a total of 3 courses.Six rats in each group were randomly selected to observe their pain thresholds,and peripheral blood of the rats was collected before the first scraping treatment and at the end of the first,second,and third courses of treatment.The serum was isolated and enzyme-linked immunosorbent assay(ELISA)was applied for the detection of rat serum interferon(IFN)-γ,interleukin(IL)-4 and IL-10.Results:Compared with the model group,the pain threshold in LDH rats in the ST group increased(P<0.05),the serum IFN-γlevel was significantly reduced(P<0.05),but the levels of IL-4 and IL-10 did not change significantly(both P>0.05).At the end of the second and third courses of treatment,the IFN-γ/IL-4 ratio was negatively correlated with the pain threshold in the rats,and the IFN-γ/IL-4 ratio was significantly reduced in the ST group(P<0.01).Conclusion:ST can help suppress the Th1 immunity in LDH rats triggered by the autologous nucleus pulposus,restore the immune balance of Th1/Th2,and reduce the pain of LDH.展开更多
文摘A new partitioning methodology is presented to accelerate 130nm and beyond large scale alternating phase shift mask(Alt PSM) design flow.This method deals with granularity self adaptively.Phase conflicts resolution approaches are described and strategies guaranteeing phase compatible during layout compaction are also discussed.An efficient CAD prototype for dark field Alt PSM based on these algorithms is implemented.The experimental results on several industry layouts show that the tool can successfully cope with the rapid growth of phase conflicts with good quality and satisfy lower resource consumption with different requirements of precision and speedup.
文摘Objective:To observe the effect of scraping therapy(ST)on the immune balance of serum helper T(Th)1/Th2 cells in autologous nucleus pulposus transplantation non-compressive lumbar disc herniation(LDH)model rats,and explore the immune mechanism of ST in reducing LDH pain.Methods:Seventy-two male Sprague-Dawley(SD)rats were randomly divided into a model group,a sham operation group and a ST group,with 24 rats in each group.Autologous nucleus pulposus transplantation non-compressive LDH models were established in the model group and ST group,while the rats in the sham operation group underwent sham operation without model establishment.On the fifth day after the model was successfully prepared,rats in the ST group received ST,once every other day,3 times as a course for a total of 3 courses.Six rats in each group were randomly selected to observe their pain thresholds,and peripheral blood of the rats was collected before the first scraping treatment and at the end of the first,second,and third courses of treatment.The serum was isolated and enzyme-linked immunosorbent assay(ELISA)was applied for the detection of rat serum interferon(IFN)-γ,interleukin(IL)-4 and IL-10.Results:Compared with the model group,the pain threshold in LDH rats in the ST group increased(P<0.05),the serum IFN-γlevel was significantly reduced(P<0.05),but the levels of IL-4 and IL-10 did not change significantly(both P>0.05).At the end of the second and third courses of treatment,the IFN-γ/IL-4 ratio was negatively correlated with the pain threshold in the rats,and the IFN-γ/IL-4 ratio was significantly reduced in the ST group(P<0.01).Conclusion:ST can help suppress the Th1 immunity in LDH rats triggered by the autologous nucleus pulposus,restore the immune balance of Th1/Th2,and reduce the pain of LDH.
