OBJECTIVE: To observe the symptom patterns(or syndromes) according to Traditional Chinese Medicine(TCM) theory in patients with various stages of colorectal cancer, and to observe the dynamic evolution process of thes...OBJECTIVE: To observe the symptom patterns(or syndromes) according to Traditional Chinese Medicine(TCM) theory in patients with various stages of colorectal cancer, and to observe the dynamic evolution process of these TCM patterns.METHODS: A prospective and cross-sectional questionnaire-based investigation was performed. Clinical data on TCM symptom patterns in patients with colorectal cancer in the perioperative period(210 cases) and adjuvant treatment period(160 cases)were collected. EPIData 3.1 together with frequency statistics and cluster analyses were performed to identify the TCM patterns based on symptom characteristics in patients with colorectal cancer, and to assess the dynamic changes in these patterns.RESULTS: In the perioperative period, from the first day of perioperative care to postoperative days 3,7, and 10, the TCM pattern showed a process of dynamic change from blood deficiency to deficiency of both Qi and Yin and the pattern of dampness and hot accumulative knotting. In the adjuvant treatment period, the TCM pattern changed from Qi deficiency and Yin deficiency inner-heat with dampness to a deficiency pattern, primarily including Yin deficiency of the liver and kidney, deficiency of Qi and blood, and spleen deficiency.CONCLUSION: Our study confirmed that variations in the dynamic evolution of TCM symptom patterns exist in patients with colorectal cancer during different treatment periods. This information is of great value in the individualized management of colorectal cancer.展开更多
This paper considers the problem of estimating the finite population total in two-phase sampling when some information on auxiliary variable is available. The authors employ an informationtheoretic approach which make...This paper considers the problem of estimating the finite population total in two-phase sampling when some information on auxiliary variable is available. The authors employ an informationtheoretic approach which makes use of effective distance between the estimated probabilities and the empirical frequencies. It is shown that the proposed cross-entropy minimization estimator is more efficient than the usual estimator and has some desirable large sample properties. With some necessary modifications, the method can be applied to two-phase sampling for stratification and non-response. A simulation study is presented to assess the finite sample performance of the proposed estimator.展开更多
基金Supported by Major Program in Traditional Chinese Medicine Technology of Zhejiang Province:Study on the Standardization and Dynamic Distribution Characteristics of Traditional Chinese Medicine ZHENG in Patients with Colorectal Cancer(No.2007ZA007)Traditional Chinese Medicine Research of Zhejiang Province-funded Project:Clinical Translational Research of Traditional Chinese Medicine ZHENG in Patients with Colorectal Cancer in Adjuvant Treatment Period(No.2011ZA031)
文摘OBJECTIVE: To observe the symptom patterns(or syndromes) according to Traditional Chinese Medicine(TCM) theory in patients with various stages of colorectal cancer, and to observe the dynamic evolution process of these TCM patterns.METHODS: A prospective and cross-sectional questionnaire-based investigation was performed. Clinical data on TCM symptom patterns in patients with colorectal cancer in the perioperative period(210 cases) and adjuvant treatment period(160 cases)were collected. EPIData 3.1 together with frequency statistics and cluster analyses were performed to identify the TCM patterns based on symptom characteristics in patients with colorectal cancer, and to assess the dynamic changes in these patterns.RESULTS: In the perioperative period, from the first day of perioperative care to postoperative days 3,7, and 10, the TCM pattern showed a process of dynamic change from blood deficiency to deficiency of both Qi and Yin and the pattern of dampness and hot accumulative knotting. In the adjuvant treatment period, the TCM pattern changed from Qi deficiency and Yin deficiency inner-heat with dampness to a deficiency pattern, primarily including Yin deficiency of the liver and kidney, deficiency of Qi and blood, and spleen deficiency.CONCLUSION: Our study confirmed that variations in the dynamic evolution of TCM symptom patterns exist in patients with colorectal cancer during different treatment periods. This information is of great value in the individualized management of colorectal cancer.
基金supported by the National Natural Science Foundation of China under Grant No.61070236
文摘This paper considers the problem of estimating the finite population total in two-phase sampling when some information on auxiliary variable is available. The authors employ an informationtheoretic approach which makes use of effective distance between the estimated probabilities and the empirical frequencies. It is shown that the proposed cross-entropy minimization estimator is more efficient than the usual estimator and has some desirable large sample properties. With some necessary modifications, the method can be applied to two-phase sampling for stratification and non-response. A simulation study is presented to assess the finite sample performance of the proposed estimator.
