外阴白色病变是指外阴皮肤、黏膜变性和色素减退的一组慢性病。以外阴瘙痒为主要症状。晚期常伴有外阴萎缩、阴道口狭窄、性交不适。严重影响身心健康。目前，治疗方法多种多样，效果不甚满意。高强度聚焦超声（HighIntensity F ocused ...外阴白色病变是指外阴皮肤、黏膜变性和色素减退的一组慢性病。以外阴瘙痒为主要症状。晚期常伴有外阴萎缩、阴道口狭窄、性交不适。严重影响身心健康。目前，治疗方法多种多样，效果不甚满意。高强度聚焦超声（HighIntensity F ocused UI trasound HIFU）治疗技术作为一种新的局部治疗手段，具有无创、有效、安全、治疗后恢复快、无辐射性损伤等优点。越来越受到临床医师的重视。我院自2008年6月至2010年5月应用CEF-I型超声波妇科治疗仪对68例外阴白色病变患者进行治疗。本文将临床效果进行分析、概述如下：展开更多
AIM： To compare the features of biochemical metabolic changes detected by hepatic phosphorus-31 magnetic resonance spectroscopy （^31p MRS） with the liver damage score （LDS） and pathologic changes in rabbits and t...AIM： To compare the features of biochemical metabolic changes detected by hepatic phosphorus-31 magnetic resonance spectroscopy （^31p MRS） with the liver damage score （LDS） and pathologic changes in rabbits and to investigate the diagnostic value of ^31p MRS in acute hepatic radiation injury. METHODS： A total of 30 rabbits received different radiation doses （ranging 5-20 Gy） to establish acute hepatic injury models. Blood biochemical tests, ^31p MRS and pathological examinations were carried out 24 h after irradiation. The degree of injury was evaluated according to LD5 and pathology. Ten healthy rabbits served as controls. The MR examination was performed on a 1.5 T imager using a 1H/^31P surface coil by the 2D chemical shift imaging technique. The relative quantities of phosphomonoesters （PME）, phosphodiesters （PDE）, inorganic phosphate （Pi） and adenosine triphosphate （ATP） were measured. The data were statistically analyzed. RESULTS： （1） Relative quantification of phosphorus metabolites： （a） ATP： there were significant differences （P 〈 0.05） （LDS-groups：control group vs mild group vs moderate group vs severe group, 1.83±0.33 vs 1.55±0.24 vs 1.27±0.09 vs 0.98±0.18; pathological groups： control group vs mild group vs moderate group vs severe group, 1.83±0.33 vs 1.58±0.25 vs 1.32±0.07 vs 1.02±0.18） of ATP relative quantification among control group, mild injured group, moderate injured group, and severe injured group according to both LDS grading and pathological grading, respectively, and it decreased progressively with the increased degree of injury （r = -0.723, P = 0.000）. （b） PME and Pi; the relative quantification of PME and Pi decreased significantly in the severe injured group, and the difference between the control group and severe injured group was significant （P 〈 0.05） （PME： 1DS- control group vs LDS-severe group, 0.86±0.23 vs 0.58±0.22, P = 0.031; pathological control group vs pathological severe group, 0.86±0.23 vs 0.60±0.21, P = 0.037; Pi： LDS-control group vs LDS-severe group, 0.74±0.18 vs 0.43±0.14, P = 0.013; pathological control group vs pathological severe group, 0.74±0.18 vs 0.43±0.14, P = 0.005） according to LDS grading and pathological grading, respectively. （c） PDE; there were no significant differences among groups according to LDS grading, and no significant differences between the control group and experimental groups according to pathological grading. （2） The ratio of relative quantification of phosphorus metabolites： significant differences （P 〈 0.05） （LDS- moderate group and LDS-severe group vs LDS-control group and LDS-mild group, 1.94±0.50 and 1.96±0.72 vs 1.43±0.31 and 1.40±0.38） were only found in PDE/ATP between the moderate injured group, the severe injured group and the control group, the mild injured group. No significant difference was found in other ratios of relative quantification of phosphorus metabolites.CONCLUSION： ^31p MRS is a useful method to evaluate early acute hepatic radiation injury. The relative quantification of hepatic ATP levels, which can reflect the pathological severity of acute hepatic radiation injury, is correlated with LDS.展开更多
The effects of pulsing electromagnetic fields(PEMFs)on cells are very important subjects in the field of bioelectromagnetics.In this experiment,the cytogenetic effects of PEMF on domestic pig lymphocytes were tested i...The effects of pulsing electromagnetic fields(PEMFs)on cells are very important subjects in the field of bioelectromagnetics.In this experiment,the cytogenetic effects of PEMF on domestic pig lymphocytes were tested in vitro.Pig lymphocytes in RPMI 1640 medium were exposed to PEMFs of 100 kHz and 200 kHz for 12,24 and 48 hours.Chromosomal aberrations(aneuploidy,breaks,gaps,et al)were significantly increased in exposed cultures,and of these aberrations,56%chromosomal or chromatid breaks and 42%gaps induced by PEMFs were the points of pig chromosomal fragile sites.The baseline frequency of sister chromatid exchange(SCE)increased after exposing lymphocytes continuously to PEMFs of 100 kHz and 200 kHz for 48 hours.These results suggested that the exposure to PEMFs might induce a type of DNA lesion and chromosomal aberrations.展开更多
The dynamic mechanical properties of basalt affected by microwave were investigated by performing dynamic compressive tests using the SHPB system.Meanwhile,the thermal damage of the treated basalt was characterized by...The dynamic mechanical properties of basalt affected by microwave were investigated by performing dynamic compressive tests using the SHPB system.Meanwhile,the thermal damage of the treated basalt was characterized by ultrasonic non-destructive testing and nuclear magnetic resonance technology.The results show that with the increase of microwave power and exposure time,the P-wave velocity,dynamic compressive strength and elastic modulus decrease continuously,and the dynamic failure mode tends to be a more complex fracturing.The increase in microwave power and exposure time can enhance the temperature difference and transfer coefficient among minerals,hence intensifying the rock damage induced by thermal shock.展开更多
An opportunity to use laser radiation as a means to reduce negative aftermath of acute and prolonged exposure to ionizing radiation was checked. The mice were exposed to γ- rays of ^60Co （whole body irradiation） in...An opportunity to use laser radiation as a means to reduce negative aftermath of acute and prolonged exposure to ionizing radiation was checked. The mice were exposed to γ- rays of ^60Co （whole body irradiation） in the dose of 7 Gy （the transitional clinical form of the acute radiation sickness）. The dose rate at acute irradiation was 1.14 Gy/min, and at prolonged exposure, 0.027 Gy/min. Laser radiation in the dose l mJ/cm^2 was used to irradiate only the back of a mouse. First, the mice were exposed to γ-radiation, then to laser radiation. The time interval between two types of irradiation did not exceed 30 min. It was shown that the radiation protection of mice with laser radiation is possible at exposure to ionizing radiation in a wide dose interval and can reduce negative after-effects of both the acute and prolonged radiation exposure.展开更多
基金Supported by The National Natural Science Foundation of China, No. 30770626the Great Transversal Science Foundation of Zhejiang Province, China, No. 491020I20857
文摘AIM： To compare the features of biochemical metabolic changes detected by hepatic phosphorus-31 magnetic resonance spectroscopy （^31p MRS） with the liver damage score （LDS） and pathologic changes in rabbits and to investigate the diagnostic value of ^31p MRS in acute hepatic radiation injury. METHODS： A total of 30 rabbits received different radiation doses （ranging 5-20 Gy） to establish acute hepatic injury models. Blood biochemical tests, ^31p MRS and pathological examinations were carried out 24 h after irradiation. The degree of injury was evaluated according to LD5 and pathology. Ten healthy rabbits served as controls. The MR examination was performed on a 1.5 T imager using a 1H/^31P surface coil by the 2D chemical shift imaging technique. The relative quantities of phosphomonoesters （PME）, phosphodiesters （PDE）, inorganic phosphate （Pi） and adenosine triphosphate （ATP） were measured. The data were statistically analyzed. RESULTS： （1） Relative quantification of phosphorus metabolites： （a） ATP： there were significant differences （P 〈 0.05） （LDS-groups：control group vs mild group vs moderate group vs severe group, 1.83±0.33 vs 1.55±0.24 vs 1.27±0.09 vs 0.98±0.18; pathological groups： control group vs mild group vs moderate group vs severe group, 1.83±0.33 vs 1.58±0.25 vs 1.32±0.07 vs 1.02±0.18） of ATP relative quantification among control group, mild injured group, moderate injured group, and severe injured group according to both LDS grading and pathological grading, respectively, and it decreased progressively with the increased degree of injury （r = -0.723, P = 0.000）. （b） PME and Pi; the relative quantification of PME and Pi decreased significantly in the severe injured group, and the difference between the control group and severe injured group was significant （P 〈 0.05） （PME： 1DS- control group vs LDS-severe group, 0.86±0.23 vs 0.58±0.22, P = 0.031; pathological control group vs pathological severe group, 0.86±0.23 vs 0.60±0.21, P = 0.037; Pi： LDS-control group vs LDS-severe group, 0.74±0.18 vs 0.43±0.14, P = 0.013; pathological control group vs pathological severe group, 0.74±0.18 vs 0.43±0.14, P = 0.005） according to LDS grading and pathological grading, respectively. （c） PDE; there were no significant differences among groups according to LDS grading, and no significant differences between the control group and experimental groups according to pathological grading. （2） The ratio of relative quantification of phosphorus metabolites： significant differences （P 〈 0.05） （LDS- moderate group and LDS-severe group vs LDS-control group and LDS-mild group, 1.94±0.50 and 1.96±0.72 vs 1.43±0.31 and 1.40±0.38） were only found in PDE/ATP between the moderate injured group, the severe injured group and the control group, the mild injured group. No significant difference was found in other ratios of relative quantification of phosphorus metabolites.CONCLUSION： ^31p MRS is a useful method to evaluate early acute hepatic radiation injury. The relative quantification of hepatic ATP levels, which can reflect the pathological severity of acute hepatic radiation injury, is correlated with LDS.
文摘The effects of pulsing electromagnetic fields(PEMFs)on cells are very important subjects in the field of bioelectromagnetics.In this experiment,the cytogenetic effects of PEMF on domestic pig lymphocytes were tested in vitro.Pig lymphocytes in RPMI 1640 medium were exposed to PEMFs of 100 kHz and 200 kHz for 12,24 and 48 hours.Chromosomal aberrations(aneuploidy,breaks,gaps,et al)were significantly increased in exposed cultures,and of these aberrations,56%chromosomal or chromatid breaks and 42%gaps induced by PEMFs were the points of pig chromosomal fragile sites.The baseline frequency of sister chromatid exchange(SCE)increased after exposing lymphocytes continuously to PEMFs of 100 kHz and 200 kHz for 48 hours.These results suggested that the exposure to PEMFs might induce a type of DNA lesion and chromosomal aberrations.
基金supported by the National Natural Science Foundation of China(Nos.51774325,41972283,11972378).
文摘The dynamic mechanical properties of basalt affected by microwave were investigated by performing dynamic compressive tests using the SHPB system.Meanwhile,the thermal damage of the treated basalt was characterized by ultrasonic non-destructive testing and nuclear magnetic resonance technology.The results show that with the increase of microwave power and exposure time,the P-wave velocity,dynamic compressive strength and elastic modulus decrease continuously,and the dynamic failure mode tends to be a more complex fracturing.The increase in microwave power and exposure time can enhance the temperature difference and transfer coefficient among minerals,hence intensifying the rock damage induced by thermal shock.
文摘An opportunity to use laser radiation as a means to reduce negative aftermath of acute and prolonged exposure to ionizing radiation was checked. The mice were exposed to γ- rays of ^60Co （whole body irradiation） in the dose of 7 Gy （the transitional clinical form of the acute radiation sickness）. The dose rate at acute irradiation was 1.14 Gy/min, and at prolonged exposure, 0.027 Gy/min. Laser radiation in the dose l mJ/cm^2 was used to irradiate only the back of a mouse. First, the mice were exposed to γ-radiation, then to laser radiation. The time interval between two types of irradiation did not exceed 30 min. It was shown that the radiation protection of mice with laser radiation is possible at exposure to ionizing radiation in a wide dose interval and can reduce negative after-effects of both the acute and prolonged radiation exposure.
