颗粒-气体脉动速度联合PDF输运方程的封闭

在建立的颗粒 气体微团脉动速度联合PDF输运方程基础上 ,考虑到颗粒的扩散存在轨道穿越效应、连续性效应和惯性效应以及湍流的各向异性 ,应用三涡相互作用模型来封闭颗粒所见气体微团脉动速度的朗之万方程中的漂移系数 ,并应用各向异性的扩散矩阵封闭了此朗之万方程中的扩散系数 .完成了整个PDF输运方程的完全封闭 ,此输运方程可以用来模拟湍流气固 (液 )

外敷治疗外周静脉输液外渗致肿胀的研究

静脉输液是临床一项专业技术,利用大气压、液体挤压原理将药物摄入人体,从而达到治疗效果。然而药物外渗于血管周围组织,则会引起不良后果发生,轻则疼痛、肿胀,重则组织坏死,功能障碍受损。近年来为防治外周静脉输液外渗致肿胀,学者们纷纷进行了研究,其中应用外敷对其进行治疗,效果非常显著。本文就外敷治疗外周静脉输液外渗致肿胀的研究情况进行综述。

乳腺癌静脉输液港导管相关血流感染外周血CGRP、TM、PD-L1、PD-1表达及意义

目的探究乳腺癌静脉输液港导管相关血流感染外周血降钙素基因相关肽(CGRP)、血栓调节蛋白(TM)、细胞程序性死亡受体(PD)-配体1(L1)和PD-1表达及意义。方法选取中国医科大学附属盛京医院2021年2月-2023年2月收治的乳腺癌静脉输液港导管相关血流感染患者101例为感染组,据其感染程度分为轻、中和重度组,分别为29、33和39例;另随机选乳腺癌未发生静脉输液港导管相关血流感染患者103例为非感染组。统计感染组病原菌分布;比较不同组别间CGRP、TM、PD-L1、PD-1水平;分析四指标对乳腺癌静脉输液港导管相关血流感染诊断价值及与其感染程度相关性。结果101例感染组患者共检出病原菌113株,革兰阴性菌构成比最高。感染组CGRP、PD-L1水平低于非感染组,TM、PD-1水平高于非感染组(P<0.05)。中、重度组CGRP、PD-L1水平低于、TM、PD-1水平高于轻度组,且重度组水平变化高于中度组(P<0.05)。CGRP、PD-L1与乳腺癌静脉输液港导管相关血流感染程度呈负相关(P<0.05),TM、PD-1与其则呈正相关(P<0.05)。CGRP、TM、PD-L1、PD-1联合检测诊断乳腺癌静脉输液港导管相关血流感染曲线下面积(AUC)值高于各指标单一检测(P<0.05)。结论乳腺癌静脉输液港导管相关血流感染主要病原菌为革兰阴性菌,CGRP、TM、PD-L1、PD-1表达异常与其感染程度有关,四指标联合检测可提高其诊断价值。

Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis

AIM： To evaluate the efficacy of continuous regional arterial infusion therapy （CRAI） with gabexate mesilate and antibiotics for severe acute pancreatitis （SAP）. METHODS： We conducted a prospective study on patients who developed SAP with or without CRAI. Out of 18 patients fulfilled clinical diagnostic criteria for SAP in Japan, 9 patients underwent CRAI, while 9 patients underwent conventional systemic protease inhibitor and antibiotics therapy （non-CRAI）. CRAI was initiated within 72 h of the onset of pancreatitis. Gabexate mesilate （2400 mg/d） was continuously administered for 3 to 5 d. The clinical outcome including serum inflammation-related parameters were examined. RESULTS- The duration of abdominal pain in the CRAI group was 1.9 =1：0.26 d, whereas that in the non-CRAI group was 4.3 ±0.50. The duration of SIRS in the CRAI group was 2.2 ± 0.22 d, whereas that in the non- CRAI group was 3.2 ± 0.28. Abdominal pain and SIRS disappeared significantly in a short period of time after the initiation of CRAI using gabexate mesilate. The average length of hospitalization significantly differed between the CRAI and non-CRAI groups, 53.3 ± 7.9 d and 87.4± 13.9 d, respectively. During the first two weeks, levels of serum CRP and the IL6/IL10 ratio in the CRAI group tended to have a rapid decrease compared to those in the non-CRAI group. CONCLUSION： The present results suggest that CRAI using gabexate mesilate was effective against SAP.

Amelioration of hemodynamics and oxygen metabolism by continuous venovenous hemofiltration in experimental porcine pancreatitis

AIM: To investigate the potential role of continuous venovenous hemofiltration (CVVH) in hemodynamics and oxygen metabolism in pigs with severe acute pancreatitis (SAP). METHODS: SAP model was produced by intraductal injection of sodium taurocholate [4%, 1 mL/kg body weight (BW)] and trypsin (2 U/kg BW). Animals were allocated either to untreated controls as group 1 or to one of two treatment groups as group 2 receiving a low-volume CVVH [20 mL/(kg·h)], and group 3 receiving a high-volume CVVH [100 (mL/kg·h)]. Swan-Ganz catheter was inserted during the operation. Heart rate, arterial blood pressure, cardiac output, mean pulmonary arterial pressure, pulmonary arterial wedge pressure, central venous pressure, systemic vascular resistance, oxygen delivery, oxygen consumption, oxygen extraction ratio, as well as survival of pigs were evaluated in the study. RESULTS: Survival time was significantly prolonged by low-volume and high-volume CVVHs, which was more pronounced in the latter. High-volume CVVH was significantly superior compared with less intensive treatment modalities (low-volume CVVH) in systemic inflammatory reaction protection. The major hemodynamic finding was that pancreatitis-induced hypotension was significantly attenuated by intensive CVVH (87.4±12.5 kPa vs116.3±7.8 kPa,P＜0.01). The development of hyperdynamic circulatory failure was simultaneously attenuated, as reflected by a limited increase in cardiac output, an attenuated decrease in systemic vascular resistance and an elevation in oxygen extraction ratio. CONCLUSION: CVVH blunts the pancreatitis-induced cardiovascular response and increases tissue oxygen extraction. The high-volume CVVH is distinctly superior in preventing sepsis-related hemodynamic impairment.

Dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation in humans

Objective： To compare the dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation （OLT） in humans. Methods： Twenty male patients undergoing liver transplantation were randomly assigned to two comparable groups of 10 patients each to receive a continuous infusion of rocuronium or atracurium under intravenous balanced anesthesia. The response of adductor pollicis to train-of-four （TOF） stimulation of unlar nerve was monitored. The infusion rates of rocuronium and atracurium were adjusted to maintain Tl/Tc ratio of 2%-10%. The total dose of each drug given during each of the three phases of OLT was recorded. Results： Rocuronium requirement, which were （0.468±0.167）mg/（kg·h） during the paleohepatic phase, decreased significantly during the anhepatic phase to （0.303±0.134）mg/（kg·h） and returned to the initial values at the neohepatic period （（0.429±0.130） mg/（kg·h））; whereas atracuruim requirements remained unchanged during orthotopic liver transplantation. Conclusions： This study showed that the exclusion of the liver from the circulation results in the significantly reduced requirement of rocuronium while the requirement of atracurium was not changed, which suggests that the liver is of major importance in the clearance of rocuronium. A continuous infusion of atracurium with constant rate can provide stable neuromuscular blockade during the three stages of OLT.

Central venous port placement in advanced breast cancer patients:comparison of the anatomic- landmark and ultrasound-guided techniques

Objective： The aim of this study was to compare the anatomic-landmark and ultrasound-guided techniques in the placement of an internal jugular vein port in patients with advanced breast cancer. Methods： Between March 2010 and October 2010, 60 patients with advanced breast cancer underwent central venous port placement for the delivery of chemotherapy, preferably through the internal jugular vein. Patients were randomly assigned to either the anatomic-landmark or the ultrasound-guided group. Failure on first attempt, number of attempts until successful catheterization, time to successful placement, the accordance of the two placement approaches, and the demographics of each patient were recorded. Results： The consistency of the direction of two lines drawn using the anatomic-landmark and ultrasound-guided techniques or of the diameter of the internal jugular vein as determined by the two approaches was 85% （51/60）. The rate of successful place- ment at first attempt was higher in the ultrasound group than in the anatomic-landmark group （P 〈 0.05）. A greater number of attempts and longer time to successful port placement were needed in the latter （P 〈 0.05）. Conclusion： The findings of this study indicate that, in the placement of an internal jugular vein port, the ultrasound （US）-guJded technique has several advantages over the anatomic-landmark technique.

Role of calcium and magnesium infusion in prevention of oxaliplatin neurotoxicity. A phase III trial

Objective： This study is a prospective randomized, double-blind, placebo-controlled study to evaluate the effect of calcium and magnesium （Ca/Mg） infusion on amelioration of oxaliplatin neuropathy, the dose-limiting toxicity. Methods： Sixty patients with resected colorectal carcinoma （CRC） planned to receive adjuvant oxaliplatin-containing regimen were randomly assigned to two arms; Arm A： patients received Ca/Mg were given as 1 gm Ca gluconate and 1 gm MgSO4 in 250 mL of intravenous （IV） solution over 30 rain pre and post oxaliplatin infusion, and Arm B： patients received 250 mL of IV solution without Ca/Mg over 30 min pre and post oxaliplatin infusion. Primary outcome was to assess percentage of patients with oxaliplatin-induced neurotoxicity. Neurotoxicity was assessed according to the National Cancer Institute Common Terminology Criteria forAdverse Events （NCI-CTCAE） version 3.0. Results： Sixty patients in both arms were assessed, 30 with Ca/Mg infusion and 30 without. Patients developed neurotoxicity in arm A were significantly lower than that in arm B after the end of treatment; 7 （23.3%） and 14 （46.6%） respectively （P 〈 0.05）, and significantly lower duration of neuropathy in months （8 ± 2.5 vs 18 ±3） respectively （P 〈 0.001）. Conclusion： Use of IV Ca/Mg showed a statistically significant reduction of peripheral neuropathy （PN） in patients with CRC receiving oxaliplatin in the adjuvant settings.

Diode-pumped actively Q-switched Nd:YAG laser at 946 nm

A diode-pumped Nd:YAG acousto-optically(A-O) Q-switched laser at wavelength 946 nm formed with a simple plane-plane cavity has been demonstrated.The maximum average output power was 850 mW.The highest peak power was 531 W with the pulse repetition rate of 20 kHz and pulse width of 80 ns at the incident pump power of 19.5 W.

Angiographic evaluation and management of acute gastrointestinal hemorrhage

Although most cases of acute nonvariceal gastrointestinal hemorrhage either spontaneously resolve or respond to medical management or endoscopic treatment,there are still a significant number of patients who require emergency angiography and transcatheter treatment.Evaluation with noninvasive imaging such as nuclear scintigraphy or computed tomography may localize the bleeding source and/or confirm active hemorrhage prior to angiography.Any angiographic evaluation should begin with selective catheterization of the artery supplying the most likely site of bleeding,as determined by the available clinical,endoscopic and imaging data.If a hemorrhage source is identified,superselective catheterization followed by transcatheter microcoil embolization is usually the most effective means of successfully controlling hemorrhage while minimizing potential complications.This is now wellrecognized as a viable and safe alternative to emergency surgery.In selected situations transcatheter intra-arterial infusion of vasopressin may also be useful in controlling acute gastrointestinal bleeding.One must be aware of the various side effects and potential complications associated with this treatment,however,and recognize the high re-bleeding rate.In this article we review the current role of angiography,transcatheter arterial embolization and infusion therapy in the evaluation and management of nonvariceal gastrointestinal hemorrhage.

Clinical observation of capecitabine plus oxaliplatin in treatment of 68 cases with advanced gastric cancer

Objective:The aim of this study was to evaluate the response rate,time to progression(TTP),overall survival,and safety of the combination of capecitabine plus oxaliplatin in treatment of advanced gastric cancer(AGC).Methods:All the patients with advanced gastric cancer who were not received any prior chemotherapy or radiotherapy were treated with combination of capecitabine(1250 mg/m2 twice daily,days 1-14) plus oxaliplatin(130 mg/m2 as a 2-h intravenous infusion on day 1) every 3 weeks.Results:Two cases of complete response(CR) and 34 cases of partial response(PR) were confirmed,giving an overall response rate of 52.9%,of the 68 patients with advanced gastric cancer.The median TTP and overall survival for all patients were 7.3 and 11.9 months,respectively.Grade 3 leukopenia,thrombocytopenia,nausea/vomiting,and diarrhea were observed in 3,5,1,and 4 patients,respectively.Yet,no grade 4 toxicity was observed.Conclusion:Capecitabine/ oxaliplatin combination chemotherapy is active in patients with advanced gastric cancer.

Primary Results of ECRH Experiment and Electron Heat Transport on the HL-2A Tokamak

As an ordinary mainly auxiliary heating on tokamak plasma, electron cyclotron resonance heating （ ECRH ） is an useful method to the study of electron heat transport and confinement performance. In this work, primary results of ECRH experiments on the HL-2A tokamak are presented. The features of confinement and electron heat transport during ECRH are analyzed.

A HIGH RESOLUTION WIDE SWATH SAR METHOD BASED ON INTRA-PULSE NULL STEERING AND MIMO

High Resolution Wide Swath (HRWS) Synthetic Aperture Radar (SAR) often suffers from low Signal-to-Noise Ratio (SNR) due to small transmitting antenna, especially in phased array antenna systems. Digital Beam Forming (DBF) based on Single Input and Multiple Output (SIMO) achieves receiving array gain at the cost of increasing data rate. This letter proposes a new HRWS SAR method, which employs intra-pulse null steering to get receiving gain in elevation and decrease the data rate, and Multiple Input and Multiple Output (MIMO) using Space-Time Block Coding (STBC) in azimuth to get transmitting gain and receiving array gain simultaneously. The feasibility is verified by deduction and simulations.

Effect of autologous blood donation on the central venous pressure, blood loss and blood transfusion during living donor left hepatectomy

AIM： Autologous blood donation （ABD） is mainly used to reduce the use of banked blood. In fact, ABD can be regarded as acute blood loss. Would ABD 2-3 d before operation affect the CVP level and subsequently result in less blood loss during liver resection was to be determined.METHODS： Eighty-four patients undergoing living donor left hepatectomy were retrospectively divided as group Ⅰ （GⅠ） and group Ⅱ （GⅡ） according to have donated 250-300 mL blood 2-3 d before living donor hepatectomy or not. The changes of the intraoperative CVP, surgical blood loss,blood products used and the changes of perioperative hemoglobin （Hb） between groups were analyzed and compared by using Mann-Whitney Utest.RESULTS： The results show that the intraoperative CVP changes between GⅠ （n = 35） and GⅡ （n = 49） up to graft procurement were the same, subsequently the blood loss,but ABD resulted in significantly lower perioperative Hb levels in GI.CONCLUSION： Since none of the patients required any blood products perioperatively, all the predonated bloods were discarded after the patients were discharged from the hospital. It indicates that ABD in current series had no any beneficial effects, in term of cost, lowering the CVP, blood loss and reduce the use of banked blood products, but resulted in significant lower Hb in perioperative period.

Integrability Aspects and Soliton Solutions for a System Describing Ultrashort Pulse Propagation in an Inhomogeneous Multi-Component Medium

For the propagation of the ultrashort pulses in an inhomogeneous multi-component nonlinear medium, a system of coupled equations is analytically studied in this paper. Painleve analysis shows that this system admits the Painleve property under some constraints. By means of the Ablowitz-Kaup-Newell-Segur procedure, the Lax pair of this system is derived, and the Darboux transformation （DT） is constructed with the help of the obtained Lax pair. With symbolic computation, the soliton solutions are obtained by virtue of the DT algorithm. Figures are plotted to illustrate the dynamical features of the soliton solutions. Characteristics of the solitons propagating in an inhomogeneous multi-component nonlinear medium are discussed： （i） Propagation of one soliton and two-peak soliton; （ii） Elastic interactions of the parabolic two solitons; （iii） Overlap two head-on solitons and two head-on two-peak solitons; （v） Two （vi） Decomposition phenomenon of one soliton into two solitons. phenomenon between two solitons; （iv） Collision of different types of interactions of the three solitons; ultrashort-pulse propagation in the inhomogeneous multi-component The results might be useful in the study on the nonlinear media.

Continuous-infusion 5-Fluorouracil versus Xeloda for gastrointestinal cancer: A safety and efficacy observation

Objective： We assessed the safety and efficacy of two regimens for patients with gastrointestinal cancers： continuous-infusion （CI） schedules of 5-Fluorouracil （5-Fu） plus a platinum （cisplatin or oxaliplatin） with/or without paclitaxel （regimen A） versus Xeloda plus a platinum （cisplatin or oxaliplatin） with/or without paclitaxel for oral use （regimen B） in patients with gastrointestinal cancers. Methods： Between May 2003 and May 2005, 84 patients diagnosed in Jiangsu Cancer Hospital ＆ Research Institute with locally advanced esophageal, gastnc or colorectal cancer were registered. Regimen A and B consisted of either 5-Fu 0.375 CI days 1-14, every 28 days （n = 44）, or Xeloda 1000 mg twice daily, days 1-14, every 28 days （n = 40）. For both regimen A and B, IV cisplatin 25 mg/m^2 was administered on day 1, 2 and 3 （or Oxaliplatin 75mg/m^2 on day 1, 8 and 15） with or without paclitaxel 60-75 mg/m^2 on day1, 8 and 15. Results： Patients receiving regimen B experienced significantly less stomatitis （P 〈 0.05） and diarrhea （P 〈 0.05）, than those receiving regimen A. Prevalence of nausea/vomiting, alopecia, neutropenia, and hand-foot syndrome without significant difference between two regimens. No treatment related death occurred during study period. Regimen B demonstrates a similar, favorable safety profile in this study. Response rates and rates of clinical benefit for regimen A and B were 40.9%, 40.0% and 43.2%, 65.0% respectively. Conclusion： Based on its improved safety profile and improved rate of clinical benefit, Xeloda has the potential to replace CI 5-FU as an alternative treatment for patients with gastrointestinal cancers.

Controllable Optical Solitons in Optical Fiber System with Distributed Coefficients

We present how to control the dynamics of optical solitons in optical fibers under nonlinearity and dispersion management, together with the fiber loss or gain. We obtain a family of exact solutions for the nonlinear Schrfidinger equation, which describes the propagation of optical pulses in optical fibers, and investigate the dynamical features of solitons by analyzing the exact analytical solutions in different physical situations. The results show that under the appropriate condition, not only the group velocity dispersion and the nonlinearity, but also the loss/gain can be used to manipulate the light pulse.

A UWB communication system based on dechirp pulse compression and OOK modulation

In this paper,a novel UWB communication system structure is proposed.The transmitted signal uses OOK modulation and chirp spread spectrum.The received signal first goes through a dechirp pulse compression process,and then is processed with a two-level sliding correlation algorithm for coarse timing synchronization and fine timing synchronization.After the SNR estimation,the signal is demodulated by an energy detection method.An integrated system level simulation model is established,and the performance of this system is evaluated over the AWGN channel,IEEE 802.15.3a CM1 and CM4 channels.The theoretical analysis and simulation results show that this UWB communication system can effectively reduce the sampling rate and signal processing speed at the receiver,and it is more suitable for long-distance and low-rate UWB communications with high spreading gain.

Conductive Channel for Energy Transmission

Laser spark obtained by using a conical optics is much more appropriate to form conducting channels in atmosphere. Only two types of lasers are actively considered to be used in forming high-conductivity channels in atmosphere, controlled by laser spark： pulsed sub-microsecond gas and chemical lasers （CO2, DF （deuterium fluoride））, short pulse solid-state and UV （ultraviolet） lasers. Main advantage of short pulse lasers is their ability in forming of super long ionized channels with a characteristic diameter of- 100 mm in atmosphere along the beam propagation direction. At estimated electron densities below 1,016 cm3 in these filaments and laser wavelengths in the range of 0.5-1.0 mm, the plasma barely absorbs laser radiation. In this case, the length of the track composed of many filaments is determined by the laser intensity and may reach many kilometers at a femtosecond pulse energy of-100 mJ. However, these lasers could not be used to form high-conductivity long channels in atmosphere. The ohmic resistance of this type a conducting channels turned out to be very high, and the gas in the channels could not be strongly heated （〈 1 J）. An electric breakdown controlled by radiation of femtosecond solid-state laser was implemented in only at a length of 3 m with a voltage of 2 MV across the discharge gap （670 kV/m）. Not so long ago scientific group from P.N. Lebedev physical institute has improved that result, the discharge gap （-1m） had been broken under KrF laser irradiation when switching high-voltage （up to 390 kV/m） electric discharge by 100-ns UV pulses. Our previous result -16 m long conducting channel controlled by a laser spark at the voltage -3 MV was obtained more than 20 years ago in Russia and Japan by using pulsed CO2 laser with energy -0.5 kJ. An average electric field strength was 〈 190 kV/m. It is still too much for efficient applications.