As a solution to the breaking of pipeline under high axial force,carbon fiber composite pipe with low density and high intensity is applied to deep-sea mining transporting system.Based on the fact that the transportin...As a solution to the breaking of pipeline under high axial force,carbon fiber composite pipe with low density and high intensity is applied to deep-sea mining transporting system.Based on the fact that the transporting pipe is under the forces of gravity,inner liquid,buoyancy as well as hydrodynamic force,geometric nonlinear finite element theory has been applied to analyzing the transporting system.Conclusions can be drawn as follows.Under the interaction of waves and currents,node forces FX and FZ acted by the transporting pipe on the mining vehicle are less than 2 kN,which indicates that waves and currents have little influence on the spatial shape of the transporting pipe and the mining vehicle movement.On the other hand,the horizontal force acting on the mining ship could be as large as 106 830 N,which has great influence on the mining system.展开更多
Owing to the importance of drug delivery in cancer or other diseases' therapy, the targeted drug delivery (TDD) system has been attracting enormous interest. Herein, we model the TDD system and design a novel rod-...Owing to the importance of drug delivery in cancer or other diseases' therapy, the targeted drug delivery (TDD) system has been attracting enormous interest. Herein, we model the TDD system and design a novel rod-like nanocarrier by using the coarse grained model-based density functional theory, which combines a modified fundamental measure theory for the excluded-volume effects, Wertheim's first-order thermodynamics perturbation theory for the chain connectivity and the mean field approximation for van der Waals attraction. For comparison, the monomer nanocarrier TDD system and the no nanocarrier one are also investigated. The results indicate that the drug delivery capacity of rod-like nanocarriers is about 62 times that of the no nanocarrier one, and about 6 times that of the monomer nanocarriers. The reason is that the rod-like nanocarriers would self-assemble into the smectic phase perpendicular to the membrane surface. It is the self-assembly of the rod-like nanocarriers that yields the driving force for the targeted delivery of drugs inside the cell membrane. By contrast, the conventional monomer nanocarrier drug delivery system lacks the driving force to deliver the drugs into the cell membrane. In short, the novel rod-like nanocarrier TDD system may improve the drug delivery efficiency. Although the model in this work is simple, it is expected that the system may provide a new perspective for cancer targeted therapy.展开更多
基金Project(50975290) supported by the National Natural Science Foundation of ChinaProject(2011QNZT057) supported by the Basic Operational Cost of Special Research Funding of Central Universities in ChinaProject(11JJ5028) supported by Hunan Provincial Natural Science Foundation,China
文摘As a solution to the breaking of pipeline under high axial force,carbon fiber composite pipe with low density and high intensity is applied to deep-sea mining transporting system.Based on the fact that the transporting pipe is under the forces of gravity,inner liquid,buoyancy as well as hydrodynamic force,geometric nonlinear finite element theory has been applied to analyzing the transporting system.Conclusions can be drawn as follows.Under the interaction of waves and currents,node forces FX and FZ acted by the transporting pipe on the mining vehicle are less than 2 kN,which indicates that waves and currents have little influence on the spatial shape of the transporting pipe and the mining vehicle movement.On the other hand,the horizontal force acting on the mining ship could be as large as 106 830 N,which has great influence on the mining system.
基金supported by the National Natural Science Foundation of China (20874005, 20736002, 20821004)the National Basic Research Program of China (2011CB706900)+1 种基金Huo Yingdong Fundamental Research Foundation (121070)Novel Team (IRT0807) from Ministry of Education and the Chemical Grid Project of BUCT
文摘Owing to the importance of drug delivery in cancer or other diseases' therapy, the targeted drug delivery (TDD) system has been attracting enormous interest. Herein, we model the TDD system and design a novel rod-like nanocarrier by using the coarse grained model-based density functional theory, which combines a modified fundamental measure theory for the excluded-volume effects, Wertheim's first-order thermodynamics perturbation theory for the chain connectivity and the mean field approximation for van der Waals attraction. For comparison, the monomer nanocarrier TDD system and the no nanocarrier one are also investigated. The results indicate that the drug delivery capacity of rod-like nanocarriers is about 62 times that of the no nanocarrier one, and about 6 times that of the monomer nanocarriers. The reason is that the rod-like nanocarriers would self-assemble into the smectic phase perpendicular to the membrane surface. It is the self-assembly of the rod-like nanocarriers that yields the driving force for the targeted delivery of drugs inside the cell membrane. By contrast, the conventional monomer nanocarrier drug delivery system lacks the driving force to deliver the drugs into the cell membrane. In short, the novel rod-like nanocarrier TDD system may improve the drug delivery efficiency. Although the model in this work is simple, it is expected that the system may provide a new perspective for cancer targeted therapy.
