Objective Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The p16 protein negatively regulated cell proliferation, whereas CD44v6 is associated ...Objective Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The p16 protein negatively regulated cell proliferation, whereas CD44v6 is associated with proliferation as an important protein. Additionally, CD44v6 is an important nuclear antigen closely correlated to tumor metastasis. Tlle present study aims to investigate the expression and significance of Bmi-1, p16, and CD44v6 in uterine cervical carcinoma （UCC）. Methods A total of 62 UCC, 30 cervical neoplasic, and 20 normal cervical mucosal tissues were used ill the current study. The expression of Bmi-1, p16, and CD44v6 in these tissues was determined using immunohistochemical assay. The relationships among the expression of these indices, the clinicopathologic features of UCC, and the survival rate of UCC patients were also discussed. The correlation between Bmi-1 protein expression and p16 or CD44v6 protein in UCC was analyzed. Results The expression of Bmi-l, p16, and CD44v6 was significantly high in cervical carcinoma compared with that in tlle cervical neoplasia and normal colorectal mucosa （P〈0.05）. The over-expression of Bmi-1 protein in UCC was apparently related to the distant metastasis （P〈0.01） and the tumor, nodes and metastasis-classification, i.e. the TNM staging, World Health Organization （P〈0.05）. Nevertheless, the positive expression of p16 protein in UCC was not significantly associated with the clinicopathologic features （P〉0.05）. The Kaplan-Meier survival analysis showed that the over-expression of Bmi-1 significantly decreased the survival rate of UCC patients （P〈0.05）. A strong correlation indicated that there was statistical significance between the expression of Bmi-1 and CD44V6 proteins in UCC （r=0.419, P=0.001）. Conclusions The over-expression of Bmi-1 and CD44v6 protein closely correlate to the tumorigenesis, metastasis, and prognosis of UCC. Bmi-I and CD44v6 may be used to predict the prognosis of cervical carcinoma. Bmi-1 may indirectly regulate the expression of CD44v6 in UCC patients. The positive expression of p16 protein is possibly associated with the tumorigenesis, but not with the metastasis or prognosis of UCC.展开更多
Eastern philosophy and western science have convergent and divergent viewpoints for their explanation of consciousness. Convergence is found for the practice of meditation allowing besides a time dependent consciousne...Eastern philosophy and western science have convergent and divergent viewpoints for their explanation of consciousness. Convergence is found for the practice of meditation allowing besides a time dependent consciousness, the experience of a timeless consciousness and its beneficial effect on psychological wellbeing and medical improvements, which are confirmed by multiple scientific publications. Theories of quantum mechanics with non-locality and timelessness also show astonishing correlation to eastern philosophy, such as the theory of Penrose-Hameroff （ORC-OR）, which explains consciousness by reduction of quantum superposition in the brain. Divergence appears in the interpretation of the subjective experience of timeless consciousness. In eastern philosophy, meditation at a higher level of awareness allows the personal experience of timeless and non-dual consciousness, considered as an empirical proof for the existence of pure consciousness or spirituality existing before the material world and creating it by design. Western science acknowledges the subjective, non-dual experience, and its multiple beneficial effects, however, the interpretation of spirituality designing the material universe is in disagreement with the Darwinian Theory of mutation and selection. A design should create an ideal universe without the injustice of 3% congenital birth defects and later genetic health problems. The western viewpoint of selection is more adapted to explain congenital errors. The gap between subjectivity and objectivity, the mind-body problem, is in eastern philosophy reduced to the dominance of subjectivity over objectivity, whereas western science attributes equal values to both. Nevertheless, there remains an astonishing complementarity between eastern and western practices.展开更多
Based on the analyses of Loss-on-Ignition （LOI）, carbonate content and sediment characteristics, this paper reconstructs the climatic and environmental evolution of the Gahai lake area since the late Last Deglacial ...Based on the analyses of Loss-on-Ignition （LOI）, carbonate content and sediment characteristics, this paper reconstructs the climatic and environmental evolution of the Gahai lake area since the late Last Deglacial Period. The results cover the late Last Deglacial Period and the Holocene. The climate was very unstable and rather arid during the late Last Deglacial Period. The Holocene can be divided into three periods： the early Holocene （11360-8240 cal aB. P. ）, which was dry but unstable and featured rising temperatures, the mid-Holocene （8240-3200 cal aB. P. ）, which was warm and wet and the late Holocene （ since 3200 cal aBP）, which was cold and dry. Results also show a warm-wet event around 1500 cal aB. P.展开更多
Late Cretaceous sea inundation of major continents, surprisingly did not affect Indian block except by two major subaerial events of Large Igneous Provinces （LIPs）. Marion hotspot induced LIP of Mahajanga Flood Bas...Late Cretaceous sea inundation of major continents, surprisingly did not affect Indian block except by two major subaerial events of Large Igneous Provinces （LIPs）. Marion hotspot induced LIP of Mahajanga Flood Basalt （ca. 92Ma） in Madagascar triggered high intensity earthquake along Narmada Lineament and permitted a short lived marine transgression during late Turonian with spectacular estuarine deposits of limited thickness, preserved as archive of “Greenhouse Climatic Record” ？ Reunion hotspot induced LIP of Deccan Flood Basalt, stretching from western to eastern India around Rajahmundry area attracted worldwide attention for the unique fauna and flora preserved in the intertrappean beds straddling Cretaceous-Palaeogene boundary. This massive subaerial LIP （ca. 66Ma） permitted fairly deep penetration of sea along collision facing Subathu-Dogadda Line-ament during late Maastrichtian-Danian, but due to thick vegetation cover, tectonic disturbance and scarce out-crops the evidence is less straightforward than along Narmada rift.展开更多
Since Late Proterozoic era, the Korean Peninsula has been evolved into a state with relatively stable regions and orogenic belts which were developed differently each other. The Late Paleozoie （Late Carboniferous-Ear...Since Late Proterozoic era, the Korean Peninsula has been evolved into a state with relatively stable regions and orogenic belts which were developed differently each other. The Late Paleozoie （Late Carboniferous-Early Triassic） sediments are well developed in the Korean Peninsula, and called the Pyongan System. The Pyongan System from Late Carboniferous to Lower Triassic is distributed in the Pyongnan and Hyesan-Riwon Basins, and Rangrim Massif, and divided into Hongjom （ C2 ）, Ripsok （ C2 ）, Sadong （ C2-P1 ）, Kobangsan and Rokam （Taezhawon） （P2-T1） sequences. The sediments of the Tumangang Orogenic Belt are called Tuman System which is composed of the Amgi Series, consisting of elastic formation with mafic effusive material, overlaid by the Kyeryongsan Series, consisting mainly of marie volcano sediments. The Songsang Series which rests on the Kyeryongsan Series mainly consists of elastic formation with minor felsic effusive material. In the Tumangang Orogenic Belt the tectonic movement, called Tumangang Tectonic Movement, occurred in the Lower Permian-Lower Triassic.展开更多
This article first summarizes the concept systems and models of creative industries, then compares China＇s international competitiveness index, import and export value, sub-sector indicators with developed countries ...This article first summarizes the concept systems and models of creative industries, then compares China＇s international competitiveness index, import and export value, sub-sector indicators with developed countries and other world economics from 2002 to 2008, analyzes the present trends, features and problems, and discusses irrational structure of China＇ s creativity goods and services export, imbalance value between import and export, insufficient generating and consuming of original creativities through the international creative industries trade statistics at last.展开更多
The paper considers the economic consequences of Tahoku earthquake occurred on March 11,2011 at 5：46：23 （UT） at the distance of 70 km from the northeast shore of Japanese coast Honshu. This earthquake had a magnit...The paper considers the economic consequences of Tahoku earthquake occurred on March 11,2011 at 5：46：23 （UT） at the distance of 70 km from the northeast shore of Japanese coast Honshu. This earthquake had a magnitude of 9 and became the strongest in the whole history of the seismological observations in this part of the planet. The generated tsunami killed more than 15,700 people, damaged 332,395 buildings and 2,126 roads. The total economic loss in Japan was estimated at $309 billion. The catastrophe in Japan also impacted global economy. To reveal its impact, the authors used regional and global stock indexes, production indexes, stock prices of the main Japanese, European and US companies, and import/export dynamics. The authors demonstrated that the catastrophe substantially affected the markets and on the short run in some indicators it exceeded the effect of the global financial crisis. The authors concluded that it is necessary to treat possible strong earthquakes in different regions of the world as one very important factor that can affect the world economy.展开更多
基金supported by a grant from the Social Development Projects of Guangdong Sci-Tech Planning(No. 2010B031600201)
文摘Objective Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The p16 protein negatively regulated cell proliferation, whereas CD44v6 is associated with proliferation as an important protein. Additionally, CD44v6 is an important nuclear antigen closely correlated to tumor metastasis. Tlle present study aims to investigate the expression and significance of Bmi-1, p16, and CD44v6 in uterine cervical carcinoma （UCC）. Methods A total of 62 UCC, 30 cervical neoplasic, and 20 normal cervical mucosal tissues were used ill the current study. The expression of Bmi-1, p16, and CD44v6 in these tissues was determined using immunohistochemical assay. The relationships among the expression of these indices, the clinicopathologic features of UCC, and the survival rate of UCC patients were also discussed. The correlation between Bmi-1 protein expression and p16 or CD44v6 protein in UCC was analyzed. Results The expression of Bmi-l, p16, and CD44v6 was significantly high in cervical carcinoma compared with that in tlle cervical neoplasia and normal colorectal mucosa （P〈0.05）. The over-expression of Bmi-1 protein in UCC was apparently related to the distant metastasis （P〈0.01） and the tumor, nodes and metastasis-classification, i.e. the TNM staging, World Health Organization （P〈0.05）. Nevertheless, the positive expression of p16 protein in UCC was not significantly associated with the clinicopathologic features （P〉0.05）. The Kaplan-Meier survival analysis showed that the over-expression of Bmi-1 significantly decreased the survival rate of UCC patients （P〈0.05）. A strong correlation indicated that there was statistical significance between the expression of Bmi-1 and CD44V6 proteins in UCC （r=0.419, P=0.001）. Conclusions The over-expression of Bmi-1 and CD44v6 protein closely correlate to the tumorigenesis, metastasis, and prognosis of UCC. Bmi-I and CD44v6 may be used to predict the prognosis of cervical carcinoma. Bmi-1 may indirectly regulate the expression of CD44v6 in UCC patients. The positive expression of p16 protein is possibly associated with the tumorigenesis, but not with the metastasis or prognosis of UCC.
文摘Eastern philosophy and western science have convergent and divergent viewpoints for their explanation of consciousness. Convergence is found for the practice of meditation allowing besides a time dependent consciousness, the experience of a timeless consciousness and its beneficial effect on psychological wellbeing and medical improvements, which are confirmed by multiple scientific publications. Theories of quantum mechanics with non-locality and timelessness also show astonishing correlation to eastern philosophy, such as the theory of Penrose-Hameroff （ORC-OR）, which explains consciousness by reduction of quantum superposition in the brain. Divergence appears in the interpretation of the subjective experience of timeless consciousness. In eastern philosophy, meditation at a higher level of awareness allows the personal experience of timeless and non-dual consciousness, considered as an empirical proof for the existence of pure consciousness or spirituality existing before the material world and creating it by design. Western science acknowledges the subjective, non-dual experience, and its multiple beneficial effects, however, the interpretation of spirituality designing the material universe is in disagreement with the Darwinian Theory of mutation and selection. A design should create an ideal universe without the injustice of 3% congenital birth defects and later genetic health problems. The western viewpoint of selection is more adapted to explain congenital errors. The gap between subjectivity and objectivity, the mind-body problem, is in eastern philosophy reduced to the dominance of subjectivity over objectivity, whereas western science attributes equal values to both. Nevertheless, there remains an astonishing complementarity between eastern and western practices.
文摘Based on the analyses of Loss-on-Ignition （LOI）, carbonate content and sediment characteristics, this paper reconstructs the climatic and environmental evolution of the Gahai lake area since the late Last Deglacial Period. The results cover the late Last Deglacial Period and the Holocene. The climate was very unstable and rather arid during the late Last Deglacial Period. The Holocene can be divided into three periods： the early Holocene （11360-8240 cal aB. P. ）, which was dry but unstable and featured rising temperatures, the mid-Holocene （8240-3200 cal aB. P. ）, which was warm and wet and the late Holocene （ since 3200 cal aBP）, which was cold and dry. Results also show a warm-wet event around 1500 cal aB. P.
文摘Late Cretaceous sea inundation of major continents, surprisingly did not affect Indian block except by two major subaerial events of Large Igneous Provinces （LIPs）. Marion hotspot induced LIP of Mahajanga Flood Basalt （ca. 92Ma） in Madagascar triggered high intensity earthquake along Narmada Lineament and permitted a short lived marine transgression during late Turonian with spectacular estuarine deposits of limited thickness, preserved as archive of “Greenhouse Climatic Record” ？ Reunion hotspot induced LIP of Deccan Flood Basalt, stretching from western to eastern India around Rajahmundry area attracted worldwide attention for the unique fauna and flora preserved in the intertrappean beds straddling Cretaceous-Palaeogene boundary. This massive subaerial LIP （ca. 66Ma） permitted fairly deep penetration of sea along collision facing Subathu-Dogadda Line-ament during late Maastrichtian-Danian, but due to thick vegetation cover, tectonic disturbance and scarce out-crops the evidence is less straightforward than along Narmada rift.
文摘Since Late Proterozoic era, the Korean Peninsula has been evolved into a state with relatively stable regions and orogenic belts which were developed differently each other. The Late Paleozoie （Late Carboniferous-Early Triassic） sediments are well developed in the Korean Peninsula, and called the Pyongan System. The Pyongan System from Late Carboniferous to Lower Triassic is distributed in the Pyongnan and Hyesan-Riwon Basins, and Rangrim Massif, and divided into Hongjom （ C2 ）, Ripsok （ C2 ）, Sadong （ C2-P1 ）, Kobangsan and Rokam （Taezhawon） （P2-T1） sequences. The sediments of the Tumangang Orogenic Belt are called Tuman System which is composed of the Amgi Series, consisting of elastic formation with mafic effusive material, overlaid by the Kyeryongsan Series, consisting mainly of marie volcano sediments. The Songsang Series which rests on the Kyeryongsan Series mainly consists of elastic formation with minor felsic effusive material. In the Tumangang Orogenic Belt the tectonic movement, called Tumangang Tectonic Movement, occurred in the Lower Permian-Lower Triassic.
文摘This article first summarizes the concept systems and models of creative industries, then compares China＇s international competitiveness index, import and export value, sub-sector indicators with developed countries and other world economics from 2002 to 2008, analyzes the present trends, features and problems, and discusses irrational structure of China＇ s creativity goods and services export, imbalance value between import and export, insufficient generating and consuming of original creativities through the international creative industries trade statistics at last.
文摘The paper considers the economic consequences of Tahoku earthquake occurred on March 11,2011 at 5：46：23 （UT） at the distance of 70 km from the northeast shore of Japanese coast Honshu. This earthquake had a magnitude of 9 and became the strongest in the whole history of the seismological observations in this part of the planet. The generated tsunami killed more than 15,700 people, damaged 332,395 buildings and 2,126 roads. The total economic loss in Japan was estimated at $309 billion. The catastrophe in Japan also impacted global economy. To reveal its impact, the authors used regional and global stock indexes, production indexes, stock prices of the main Japanese, European and US companies, and import/export dynamics. The authors demonstrated that the catastrophe substantially affected the markets and on the short run in some indicators it exceeded the effect of the global financial crisis. The authors concluded that it is necessary to treat possible strong earthquakes in different regions of the world as one very important factor that can affect the world economy.
