肺嗜酸粒细胞浸润症(pulmonary infiltration with eosinophilia,PIE)是一组以循环或组织中嗜酸粒细胞增高为特征的疾病。随着对生物学的研究进展,对本病有了更进一步的认识。致病因子嗜酸粒细胞受T辅助细胞控制,可释放很多介质颗粒及...肺嗜酸粒细胞浸润症(pulmonary infiltration with eosinophilia,PIE)是一组以循环或组织中嗜酸粒细胞增高为特征的疾病。随着对生物学的研究进展,对本病有了更进一步的认识。致病因子嗜酸粒细胞受T辅助细胞控制,可释放很多介质颗粒及大量细胞因子、花生四烯酸代谢产物、氧自由基等,这些均参与肺组织的损害过程。本病临床上以干咳、气喘、心悸、胸闷、发热等为主,偶伴有体重减轻、乏力。展开更多
Pemphigoid nodularis (PN) is a rare clinical variant of pemphigoid characterized by prurigo-like skin lesions and antibodies against BP180 and BP230 characteristic for bullous pemphigoid. Interestingly, most PN patien...Pemphigoid nodularis (PN) is a rare clinical variant of pemphigoid characterized by prurigo-like skin lesions and antibodies against BP180 and BP230 characteristic for bullous pemphigoid. Interestingly, most PN patients never develop blisters. This condition is often resistant to treatment. We describe a female patient who was initially diagnosed with hypereosinophilic dermatitis. Later on, in the presence of eosinophilic infiltrations in the gastrointestinal tract, obstructive ventilation disorder, pericardial and pleural effusions, the diagnosis of idiopathic hypereosinophilic syndrome was made. During the following 3 years she developed recalcitrant PN.展开更多
文摘肺嗜酸粒细胞浸润症(pulmonary infiltration with eosinophilia,PIE)是一组以循环或组织中嗜酸粒细胞增高为特征的疾病。随着对生物学的研究进展,对本病有了更进一步的认识。致病因子嗜酸粒细胞受T辅助细胞控制,可释放很多介质颗粒及大量细胞因子、花生四烯酸代谢产物、氧自由基等,这些均参与肺组织的损害过程。本病临床上以干咳、气喘、心悸、胸闷、发热等为主,偶伴有体重减轻、乏力。
文摘Pemphigoid nodularis (PN) is a rare clinical variant of pemphigoid characterized by prurigo-like skin lesions and antibodies against BP180 and BP230 characteristic for bullous pemphigoid. Interestingly, most PN patients never develop blisters. This condition is often resistant to treatment. We describe a female patient who was initially diagnosed with hypereosinophilic dermatitis. Later on, in the presence of eosinophilic infiltrations in the gastrointestinal tract, obstructive ventilation disorder, pericardial and pleural effusions, the diagnosis of idiopathic hypereosinophilic syndrome was made. During the following 3 years she developed recalcitrant PN.
