麻风病人体内超氧化物歧化酶与脂质过氧化物含量的变化

超氧阴离子(·O_2^-)是吞噬细胞的重要杀菌物质。超氧化物歧化酶(SOD)直接影响着体内·O_2^-的浓度。本研究分析各种类型麻风病人(LL、BL、TT、BT)体内SOD和脂质过氧化物(LPO)的变化,同时与正常人和非麻风皮肤病患者进行比较,探讨麻风病人的自由基代谢紊乱与麻风发病的关系。结果发现LL、BL活动期麻风病人组的SOD含量高于LL、BL、TT、BT痊愈病人组和TT、BT活动期病人组以及非麻风皮肤病患者组、正常对照组(P<0.05);而LPO则明显低于非麻风皮肤病患者组和正常对照组(P<0.01)。说明麻风病人体内SOD含量增高,与麻风病人主要是瘤型和界线偏瘤型麻风的发病有关。

蜂花粉水提取物对实验性胃粘膜GSH与LPO水平变化的影响

本文观察了蜂花粉水提取物对无水乙醇与０．６ｍｏｌ／ＬＨＣＩ所致的小鼠胃粘膜还原型谷胱甘肽（ＧＳＨ）和脂质过氧化物（ＬＰＯ）水平变化的影响作用。结果显示：无水乙醇与０．６ｍｏｌ／ＬＨＣｌ灌胃均可引起胃粘膜ＧＳＨ水平下降而ＬＰＯ水平升高，事先用蜂花粉水提取物灌胃对无水乙醇与０．６ｍｏｌ／ＬＨＣｌ所致的胃粘膜ＧＳＨ水平下降和ＬＰＯ水平升高均有显著的抑制作用。提示：胃粘膜ＧＳＨ水平与ＬＰＯ水平呈负相关，蜂花粉水提取物可提高胃粘膜ＧＳＨ水平、降低ＬＰＯ水平。

家兔内毒素性DIC时血清LPO含量、红细胞SOD活力的变化及意义

本实验用内毒素复制家兔DIC模型,以硫代巴比妥酸法测定血清LPO含量,以邻苯三酚法测定红细胞SOD活力,探讨二者变化及自由基反应在内毒素性DIC病理过程中的意义。结果表明:模型组血清LPO含量(9.36±2.65)与对照组(6.62±1.91)比较明显增高(P<0.01),而红细胞SOD活力(1676.41±374.01)与对照组(2225.66±411.85)比较明显降低(P<0.005)。提示自由基可能参与了DIC的病理过程并且是致组织损伤的重要因素之一。本文对该病理过程中自由基增多可能的机制进行了讨论。

Role of oxygen free radicals in patients with acute pancreatitis

AIM:The generation of oxygen free radicals has been implicated in the pathogenesis of experimental pancreatitis. The aim of this study was to determine the role of oxygen free radicals in patients with acute pancreatitis. METHODS:The plasma levels of C-reactive protein(CRP), lipid peroxide(LPO),myeloperoxidase(MPO)and superoxide dismutase(SOD)were measured in 13 patients with acute pancreatitis and 14 healthy volunteers. RESULTS:Among the patients with acute pancreatitis,there were higher plasma levels of LPO and MPO and lower SOD activity in patients with severe pancreatitis than in those with mild pancreatitis.However,there was no significant difference in the serum marker of oxidative stress no matter what the etiology was.The LPO level was especially correlated with the concentration of serum CRP and CT severity index. CONCLUSION:The oxygen free radicals may be closely associated with inflammatory process and the severity of acute pancreatitis.Especially,the concentration of plasma LPO is a meaningful index for determining the severity of the disease.