Two new 2-substituted thiazolidine-4（R）-carboxylic acids （TCAs）, 2-glusosaminal-TCA （GIcNH2Cys） and 2-N-acetyl-glueosanlinal-TCA （GlcNAeCys）, were synthesized. Their protective effects against liver toxicity i...Two new 2-substituted thiazolidine-4（R）-carboxylic acids （TCAs）, 2-glusosaminal-TCA （GIcNH2Cys） and 2-N-acetyl-glueosanlinal-TCA （GlcNAeCys）, were synthesized. Their protective effects against liver toxicity induced by acetaminophen （APAP） were investigated in a mice model. The resuits demonstrate that administration of TCAs （ i. p. , 800 mg/kg） 30 min after APAP challenge efficiently decrease ALF, AST, and LDH levels in liver. GlcNAcCys shows the best proteetive eftects, decreasing ALT, AST and LDH levels to 63%, 18.4% and 37% of the APAP group respectively. Comparison with the control showed that APAP greatly decreases total sulfhydlyl （T-SH） levels （43%）, non-protein hound sulfhydryl （NP-SH） levels （50%） and total antioxidative capabilities （57%） in the liver 24 hr after challenge. TCAs treatments 30min after APAP challenge significantly elevate sulfhydryl levels and total antioxidative capabilities. APAP administration also markedly （P 〈 0.05） increases liver lipid peroxidation to 1.65 and 1.17 times that of the control 4 hr and 24 hr after APAP administration respectively. TCAs treatments can inhibit lipid peroxidation as measured by decreased malondialdehyde （MDA） contents in liver. The histopathological results also further confirm the hepatoprotective effects of TCAs. In conclusion, our data show that TCAs, GleNAcCys particularly, have hepatoprotective anti antioxidant etfects.展开更多
Characteristics of thermal-hydraulic interaction of LBE （45w%Pb-55w%Bi） and lead with subcooled water in pool water were investigated experimentally. Two kinds of interaction zones （deformation and fragmentation） ...Characteristics of thermal-hydraulic interaction of LBE （45w%Pb-55w%Bi） and lead with subcooled water in pool water were investigated experimentally. Two kinds of interaction zones （deformation and fragmentation） and three kinds of interaction zones （solidification, deformation and fragmentation） were observed during LBE droplet/water interaction and lead droplet/water interaction, respectively. The fragmentation zone （FZ） could be identified exactly by two border lines： spontaneous nucleation temperature and minimum film boiling temperature. Within fragmentation zone, 10% to 35% tiny debris （diameter 〈 1 mm） of LBE and 5 to 8 kPa peak pressure generated with increasing the LBE temperature and no effect with increasing the subcooling of water. Only 2%-4% tiny debris （diameter 〈 1 mm） of lead and 2 kPa peak pressure generated regardless of lead and water temperature.展开更多
文摘Two new 2-substituted thiazolidine-4（R）-carboxylic acids （TCAs）, 2-glusosaminal-TCA （GIcNH2Cys） and 2-N-acetyl-glueosanlinal-TCA （GlcNAeCys）, were synthesized. Their protective effects against liver toxicity induced by acetaminophen （APAP） were investigated in a mice model. The resuits demonstrate that administration of TCAs （ i. p. , 800 mg/kg） 30 min after APAP challenge efficiently decrease ALF, AST, and LDH levels in liver. GlcNAcCys shows the best proteetive eftects, decreasing ALT, AST and LDH levels to 63%, 18.4% and 37% of the APAP group respectively. Comparison with the control showed that APAP greatly decreases total sulfhydlyl （T-SH） levels （43%）, non-protein hound sulfhydryl （NP-SH） levels （50%） and total antioxidative capabilities （57%） in the liver 24 hr after challenge. TCAs treatments 30min after APAP challenge significantly elevate sulfhydryl levels and total antioxidative capabilities. APAP administration also markedly （P 〈 0.05） increases liver lipid peroxidation to 1.65 and 1.17 times that of the control 4 hr and 24 hr after APAP administration respectively. TCAs treatments can inhibit lipid peroxidation as measured by decreased malondialdehyde （MDA） contents in liver. The histopathological results also further confirm the hepatoprotective effects of TCAs. In conclusion, our data show that TCAs, GleNAcCys particularly, have hepatoprotective anti antioxidant etfects.
文摘Characteristics of thermal-hydraulic interaction of LBE （45w%Pb-55w%Bi） and lead with subcooled water in pool water were investigated experimentally. Two kinds of interaction zones （deformation and fragmentation） and three kinds of interaction zones （solidification, deformation and fragmentation） were observed during LBE droplet/water interaction and lead droplet/water interaction, respectively. The fragmentation zone （FZ） could be identified exactly by two border lines： spontaneous nucleation temperature and minimum film boiling temperature. Within fragmentation zone, 10% to 35% tiny debris （diameter 〈 1 mm） of LBE and 5 to 8 kPa peak pressure generated with increasing the LBE temperature and no effect with increasing the subcooling of water. Only 2%-4% tiny debris （diameter 〈 1 mm） of lead and 2 kPa peak pressure generated regardless of lead and water temperature.
