讲授观的嬗变:从注入到“过程→生成”——基于高等数学教学探讨

培养科学技术发明创造人才,数学教育至关重要.然而尽管新教法的研究如火如荼,但在实际教学中却很难实施,尤其是高数教学,仍然继续着传统的"定义→性质→定理→例题"的注入方法,如此下去非常危险,所以改革传统的数学讲授观念是急中之急.展望科学发展的诉求,基于过程哲学、意会哲学理论解读新课改的三维目标,提出了"过程→生成"讲授观,并论述了实施要点.

普通高师生全程师范技能训练培养模式——基于“过程→生成”的实践教学模式

基于"过程→生成"理念,讨论了大基数师范生师范技能全程培养模式,给出了可操作性强的培养方案.

基于“过程→生成”理念的建模式教学设计——以模的剩余类加群为例

论述了基于"过程→生成"理念的建模式教学方法,给出了相应的教学案例。

基于“过程→生成”理念的研究性教学设计——以矩阵对角化问题为例

论述了基于"过程→生成"理念的研究性教学模式,给出了相应的教学案例。

基于“过程→生成”教学理念的中小学生数感培养研究

帮助中小学生建立和发展数感是数学教学的重要任务.基于"过程→生成"教学理念,从"数感"核心素养的内涵、研究现状、培养理念及培养策略四个方面进行讨论,旨在通过数感培养来提升中小学生的数学核心素养.

基于“过程→生成”教学理念的中小学生数据分析观念培养研究

为帮助中小学生建立与发展数据分析观念,文章基于"过程→生成"教学理念,从"数据分析观念"核心素养的内涵、研究现状、培养理念及培养策略四个方面进行探讨,旨在通过数据分析观念培养来提升中小学生的数学核心素养.

摒弃传统,弱化建构:提升核心素养教学之路

文章基于美国"建构主义教学:成功还是失败"的大辩论,分析了建构主义教学与传统主义教学利弊及其冲突之根源,认为传统的讲授法不利于核心素养的提升而须摒弃,建构主义教学虽有利于创新人才的培养却难以践行则需弱化;认为二者观念冲突是因为各走极端、各行其是、互不协调配合;认为摆正世界观、综合认知论、避免走极端是教学改革的方向。进而提出了广义建构教学思想,并且进一步说明了"过程→生成"教学理念是支持广义建构教学的理想选择。

New Process for Extracting Oil and Starch from Tea Seeds

A new process for extracting oil and starch from tea seed was introduced. The new process included one special link compared with all of the processes used now for tea seed oil and starch production. The link was static fermentation by which oil bodies and starch were separated naturally from tea seeds. By the process, tea seed oil and starch which were in conformity with government standards about edible oil and starch were successfully produced with 16% and 8% of production rate, respectively. The new process has many advantages, such as more simple equipments, lower production cost and whole natural products, etc..

Side population cells isolated from KATO Ⅲ human gastric cancer cell line have cancer stem cell-like characteristics

AIM: To investigate whether the side population (SP) cells possess cancer stem cell-like characteristics in vitro and the role of SP cells in tumorigenic process in gastric cancer. METHODS: We analyzed the presence of SP cells indifferent human gastric carcinoma cell lines, and then isolated and identified the SP cells from the KATO Ⅲ human gastric cancer cell line by flow cytometry. The clonogenic ability and self-renewal were evaluated by clone and sphere formation assays. The related genes were determined by reverse transcription polymerase chain reaction. To compare tumorigenic ability, SP and non-side population (NSP) cells from the KATO Ⅲ human gastric cancer cell line were subcutaneously injected into nude mice. RESULTS: SP cells from the total population accounted for 0.57% in KATO Ⅲ, 1.04% in Hs-746T, and 0.02% in AGS (CRL-1739). SP cells could grow clonally and have self-renewal capability in conditioned media. The expression of ABCG2, MDRI, Bmi-1 and Oct-4 was different between SP and NSP cells. However, there was no apparent difference between SP and NSP cells when they were injected into nude mice. CONCLUSION: SP cells have some cancer stem celllike characteristics in vitro and can be used for studying the tumorigenic process in gastric cancer.

Arg-X Protease-Sensitive in Supramolecular Structures of Interphase Cell Nucleus during Growth Morphogenesis Mature Germs of Wheat

Abstract： In the present study was investigated Arg-X protease-sensitive in supramolecular-genome compartments （nucleoplasm, chromatin, nuclear matrix）, during the period of the transcriptional activation of chromatin when the growth processes was initiated in the mature germs of winter and transformed from it spring wheat. The germs have been separated from endosperm from 0 h （air-dry seed） up to 21 h in each 3 h after the start of seeds soaking. Cell nucleus have been allocated from germs and cleared, and then from them supramolecular-genome compartments were extracted by increasing ionic strength of solution. The Arg-X （tryptase） activity was assessed by cleavage of Arg-X bonds in the arginine-enriched protein protamine in all nuclear fractions. In the present study have shown what Arg-X protease-sensitives zones can be located on the supramolecular structures of chromatin matrix in processes of realization of ontogenetic programs of development in mature germs of the winter and transformed from it spring wheat. Arg-X protease-sensitive can translocate and coordinated in heteropolymer structures on the same genetic matrix. Questions of epigenetic mechanisms are discussed.

Role of gastrin-peptides in Barrett's and colorectal carcinogenesis

Gastrin is the main hormone responsible for the stimulation of gastric acid secretion;in addition,gastrin and its derivatives exert proliferative and antiapoptotic effects on several cell types.Gastrin synthesis and secretion are increased in certain situations,for example,when proton pump inhibitors are used.The impact of sustained hypergastrinemia is currently being investigated.In vitro experiments and animal models have shown that prolonged hypergastrinemia may be related with higher cancer rates;although,this relationship is less clear in human beings.Higher gastrin levels have been shown to cause hyperplasia of several cell types;yet,the risk for developing cancer seems to be the same in normo-and hypergastrinemic patients.Some tumors also produce their own gastrin,which can act in an autocrine manner promoting tumor growth.Certain cancers are extremely dependent on gastrin to proliferate.Initial research focused only on the effects of amidated gastrins,but there has been an interest in intermediates of gastrin in the last few decades.These intermediates aren't biologically inactive;in fact,they may exert greater effects on proliferation and apoptosis than the completely processed forms.In certain gastrin overproduction states,they are the most abundant gastrin peptides secreted.The purpose of this review is to examine the gastrin biosynthesis process and to summarize the results from different studies evaluating the production,levels,and effects of the main forms of gastrin in different overexpression states and their possible relationship with Barrett's and colorectal carcinogenesis.

ATF4 regulates lipid metabolism and thermogenesis

Activating transcription factor 4 （ATF4） has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed that Atf4- deficient mice are lean, suggesting a possible role for ATF4 in regulating lipid metabolism. The goal of our current study is to investigate the involvement of ATF4 in lipid metabolism and elucidate the underlying mechanisms. Studies using Atf4-deficient mice revealed increased energy expenditure, as measured by oxygen consumption. These mice also showed increases in lipolysis, expression of uncoupling protein 2 （UCP2） and p-oxidation genes and decreases in expression of lipogenic genes in white adipose tissue （WAT）, suggesting increased utilization and decreased synthesis of fatty acids, respectively. Expression of UCP1, 2 and 3 was also increased in brown adipose tissue （BAT）, suggesting increased thermogenesis. The effect of ATF4 deletion on expression of UCPs in BAT suggests that increased thermogenesis may underlie increased energy expenditure. Thus, our study identifies a possible new function for ATF4 in regulating lipid metabolism and thermogenesis.

An Improved Water-filled Pulse Tube Method Using Time Domain Pulse Separation Method

Based on existing low-frequency water-filled impedance tube testing facilities, which is a part of the Low Frequency Facility of the Naval Undersea Warfare Center in Beijing, an improved water-filled pulse tube method is presented in this short paper. This proposed study is significantly different from the conventional pulse tube method because of the capability for a single plane damped sine pulse wave to generate in the water-filled pulse tube with a regular waveform and short duration time of about 1ms. During the generation process of the pulse, an inverse filter principle was adopted to compensate the transducer response. The effect of the characteristics of tube termination can be eliminated through the generation process of the pulse. Reflection coefficient from a water/air interface was measured to verify the proposed method. When compared with the expected theoretical values, a relatively good agreement can be obtained in the low frequency range of 500-2 000 Hz.

Comparison of Beer Quality Produced Using Malt from Kosovo and Other Countries

Aiming to optimize the beer production process by improving the properties of beer and reducing production costs at the J.S.C. ＂Birra Peja＂ brewery, Peja, Kosovo, this study did an evaluation of beer produced using six different malts. Four of the six studied malts were produced in four European countries： Ukraine, Croatia, Serbia and Kosovo; and, the other two malts were obtained from two （2） 30：70 proportion mixtures： one from Kosovo and Ukraine and another one from Kosovo and Croatia. Chemical, microbiological, sensory and tasting analyses were carried on beers produced by these malts. The study included three working groups from： ＂Birra Peja＂; the Agricultural University of Tirana, Albania and ＂Union Brewery＂, Ljubljana, Slovenia. Chemical and microbiological tests were based on methods under the EBC （European Beer Convention） and MEBAK （Mitteleurop^iische Brautechnische Analysenkommision e.V.） guidelines. The analyses and assessments made for the quality of beer have come to the conclusion that beer produced by Croatian origin malt corresponds to a better quality beer.

Multi Agent Systems for Fault States Diagnostics and Equipment and Process Management of Yogurt Ripening Tank

It is impossible to plan in advance unpredictable phenomena at monitoring, diagnosis and control of industrial batch and continuous equipment and processes such as chemical composition of the raw materials, the process leads to unexpected reactions and changes its parameters, etc. The agent is active, a program entity, has its own ideas how to perform the tasks of the own agenda. Agents perceive, behave ＂reasonably＂, communicate with other agents. Agents can represent equipment and operations in batch processes as recommended by the ISA $88. Jadex system is based on Java language and on FIPA org. recommendations. The description of ripening tank T406 and recipe for yogurt production in the holding of MADETA Corp. in the Czech Rep. It is described modeling and displaying of＂normal＂ and error, fault unit state of the ripening tank. Agents are within the Jadex system and describing the behavior of ripening tank T406 with state diagrams-automata and assist in diagnosing of fault states. States are described in XML language-SCXML （State Charts XML）. Jadex Control Center-JCC represents a major access point to use for operating in real time.

A 2011 drought event affecting distribution of nutrients and chlorophyll in the Zhujiang River estuary

During the summer of 2011, a severe drought event occurred throughout the Zhujiang （Pearl） River Basin of South China. This decreased runoffinto the river, resulting in increased salinity and reduced suspended substance. To examine the effects of this extreme drought on the distribution of nutrients and chlorophyll, we compared two surveys from 2006 and 20ll. Results show that dissolved inorganic nitrogen concentration did not change from 2006 to 2011, whereas the proportions of NOR and NH4＋ to DIN in 2011 increased. PO4 3- concentration was lower in 2011 than in 2006, whereas there was no difference in SiO3 2- concentration between these years. Correlation coefficients of salinity with levels of NO3-, NO2-, NH4＋, PO4 3- and SiO3 2- in 2011 were all much higher than those in 2006, suggesting greater conservation of dissolved nutrients during the extreme drought event. Furthermore, calculated amounts of regenerated nitrate and phosphorus and their proportions to observed nutrients in 2011 were much lower than in 2006, indicating that nutrient regeneration decreased during the extreme drought period. Mean concentration of chlorophyll a （Chl-a） was considerably higher in 2011 than in 2006, and a harmful algal bloom of Cochlodinium geminatum was observed in the estuary, owing to water stagnancy and lower turbidity as a consequence of drought. Therefore, the extreme drought event in 2011 changed the composition ratio of nutrients, enhanced nutrient conservative behavior, and reduced nutrient regeneration. This affected some key ecological processes in the estuary.

Synchronization in Complex Networks with Multiple Connections

In this paper a class of networks with multiple connections are discussed. The multiple connections include two different types of links between nodes in complex networks. For this new model, we give a simple generating procedure. Furthermore, we investigate dynamical synchronization behavior in a delayed two-layer network, giving corresponding theoretical analysis and numerical examples.

Utilization of Crude Glycerol by Yarrowia lipolytica IMUFRJ 50678 in Bioproduct Production

Transesterification is the most common production process for biodiesel. From this reaction, a glycerin phase is produced that is impure, thus lowering market value. However, because it is rich in carbon, it is an alternative for generating bioproducts with a higher added value through bioconversion by microorganisms. The aim of this study was to screen parameters, such as pH （4, 5, 6, 7 and 8） and the initial glycerol concentration at 30 ± ℃ with agitation at 150 rpm for bioemulsifier and lipid synthesis in a submerged medium by Yarrowia lipolytica IMUFRJ 50678 from crude glycerin. The best conditions for bioemulsifier production were 30 ± ℃ at pH： 6 with 50 g/L of initial substrate, which produced 2.7 g/L of lipids, from which the optimum 300.5 mg/L of triglycerides was produced over 48 h of microorganism growth.

Photolysis and Rate Constant of 2,3-butanedione with OH Radicals in the Aqueous Phase under Tropospheric Conditions

Photolysis rate （J1） and reaction rate constants （kl） for the biacetyl （butane-2,3-dione） were evaluated in aqueous phase using a continuous photolysis system with a conventional Xe-Hg arc lamp as a light source. The OH radicals was generated by H2OE/UV process and biacetyl （CH3C（O）C（O）CH3） concentrations were monitored using 2,4-DNPH derivatization method. 2,3-butanedione molecule is widely present in the atmosphere, it have been detected in hydrometeors （fogs, rain, and clouds） and at a significant yield （up to 10μmolar）. The measurements were performed at 294 K and with free pH values. Our results lead to the following obtained values： J1= 3×10^-4 S^-1 and k1 = （6.17±0.95）×10^8 M^-1·s^-1.The uncertainty listed above is ±15%.

Key nitrogen biogeochemical processes revealed by the nitrogen isotopic composition of dissolved nitrate in the Changjiang River estuary, China

Seasonal variations in the nitrogen isotopic composition of dissolved nitrate （δ15NO3） were investigated in the surface waters of the Changjiang River estuary in 2009 and 2010. δ15NO3 varied between -4.6‰ and 8.9%0 with changes in temperature, salinity, dissolved oxygen concentrations, and the composition of the dissolved inorganic nitrogen pool. In February, biological processes decreased because of low temperature, and the mean δ15NO3 near the river mouth was 2.4%0. In May, δ15NO3 was the highest in the surface waters among all seasons. Analysis on the conservative mixing revealed assimilation, and this finding is supported by positive relationship between Chl a and δ15NO3. The fractionation factor of assimilation was estimated to be 2.0‰ by the Rayleigh equation. Nitrification was supported based on the mixing behaviors in November 2010 and the low δ15NO3 values in May and November 2009. The high ammonium concentrations in the adjacent marine area and positive relationships between total organic nitrogen and δ15NO3 in November 2010 indicated that mineralization was taking place.