Fault diagnosis and monitoring are very important for complex chemical process. There are numerous methods that have been studied in this field, in which the effective visualization method is still challenging. In ord...Fault diagnosis and monitoring are very important for complex chemical process. There are numerous methods that have been studied in this field, in which the effective visualization method is still challenging. In order to get a better visualization effect, a novel fault diagnosis method which combines self-organizing map (SOM) with Fisher discriminant analysis (FDA) is proposed. FDA can reduce the dimension of the data in terms of maximizing the separability of the classes. After feature extraction by FDA, SOM can distinguish the different states on the output map clearly and it can also be employed to monitor abnormal states. Tennessee Eastman (TE) process is employed to illustrate the fault diagnosis and monitoring performance of the proposed method. The result shows that the SOM integrated with FDA method is efficient and capable for real-time monitoring and fault diagnosis in complex chemical process.展开更多
The synthesis of ferrierite(FER)zeolite using piperidine as an organic structure‐directing agent was investigated.X‐ray diffraction,X‐ray fluorescence,N2‐adsorption,and scanning electron microscopy were used to ch...The synthesis of ferrierite(FER)zeolite using piperidine as an organic structure‐directing agent was investigated.X‐ray diffraction,X‐ray fluorescence,N2‐adsorption,and scanning electron microscopy were used to characterize the crystal phases,textural properties,and particle morphologies of the zeolite samples.The crystallization behavior of the FER zeolite was found to be directly related to crystallization temperature.At150?C,pure FER phase was observed throughout crystallization.At160–170?C,MWW phase appeared first and gradually transformed into FER phase over time,indicating that the FER phase was thermodynamically favored.In the piperidine‐Na2O‐H2O synthetic system,alkalinity proved to be the crucial factor determining the size and textural properties of FER zeolite.Furthermore,the obtained FER samples exhibited good catalytic performance in the skeletal isomerization of1‐butene.展开更多
In this paper, the nitration characteristic of alcohols with mixed acid for the synthesis of energetic mate-rials in a stainless steel microreactor was investigated experimentally. The nitration of iso-octanol with HN...In this paper, the nitration characteristic of alcohols with mixed acid for the synthesis of energetic mate-rials in a stainless steel microreactor was investigated experimentally. The nitration of iso-octanol with HNO3-H2SO4 mixed acid was chosen as a typical model reaction which involved fast and strong exothermic liquid-liquid heterogeneous reaction process. The influences of mixed acid composition, flow rate, organic/aqueous flow ratio and reaction temperature have been investigated. The results indicated that the reaction could be con-ducted safely and stably in the microreactor at 25-40°C, which are enhanced compared to 15°C or below for safe operating conditions in the conventional reactors. Moreover, the 98.2% conversion of iso-octanol could be obtained and no by-products were detected in all cases.展开更多
A preparation process of 2-methylnaphthalene (2-MN) was proposed by isomerization, side-stream distillation and extractive distillation. The isomerization of alkyl naphthalene was catalyzed by acid-treated HBEA zeol...A preparation process of 2-methylnaphthalene (2-MN) was proposed by isomerization, side-stream distillation and extractive distillation. The isomerization of alkyl naphthalene was catalyzed by acid-treated HBEA zeolites, and the 2-MN selectivity of isomerization was 92.70%. Side-stream distillation and extractive distillation were investigated by simulation, and effects of operation parameters on 2-MN were studied. Further, the simulated results were verified by experiment. Under the optimal condition, the mass fraction of 2-MN reached to 98.09%; in the oroduct, and the yield was 83.84% in refining orocess.展开更多
In order to solve the problem the existing vertical handoff algorithms of vehicle heterogeneous wireless network do not consider the diversification of network's status, an optimized vertical handoff algorithm bas...In order to solve the problem the existing vertical handoff algorithms of vehicle heterogeneous wireless network do not consider the diversification of network's status, an optimized vertical handoff algorithm based on markov process is proposed and discussed in this paper. This algorithm takes into account that the status transformation of available network will affect the quality of service(Qo S) of vehicle terminal's communication service. Firstly, Markov process is used to predict the transformation of wireless network's status after the decision via transition probability. Then the weights of evaluating parameters will be determined by fuzzy logic method. Finally, by comparing the total incomes of each wireless network, including handoff decision incomes, handoff execution incomes and communication service incomes after handoff, the optimal network to handoff will be selected. Simulation results show that: the algorithm proposed, compared to the existing algorithm, is able to receive a higher level of load balancing and effectively improves the average blocking rate, packet loss rate and ping-pang effect.展开更多
The present work contributed to a new developed production method for enhancing the quality of isoamylene (IA) by adding a small amount of tertiary amyl alcohol (TAA) to the catalyst of strong acid cation exchange...The present work contributed to a new developed production method for enhancing the quality of isoamylene (IA) by adding a small amount of tertiary amyl alcohol (TAA) to the catalyst of strong acid cation exchange resin. TAA improved the selectivity of 2-methyl-2-butene (2M2B) at a high conversion level for the isomerization of IA. Compared with the other results from the current IA units, the conversion of 2-methyl- 1-butene (2M1B), the mass ratio of 2M2B to 2M1B and the selectivity of 2M2B were increased from 0.5474, 7.32 and 0.6864 to 0.72, 12 and 0.95, respectively, while the dimers content in the products decreased from 4.38% to below 1.0%. Optimized conditions for IA isomerization consisted of temperature between 28 and 33℃ and system pressure of 0.5 MPa, weight hourly space velocity of 8.0 h-1 with TAA mass fraction of 0.7%-0.9% in raw material. The results in lab supported bases for the developed process in industrial application which was later proved to be successful. In addition, a possible mechanism of the isomerization process was speculated to propose a key step of water formation in the TAA-added isomerization process and a verified experiment was conducted to support this speculation.展开更多
The potential energy surfaces for butanone isomerization have been investigated by density function theory calculation. Six main reaction pathways are confirmed using the intrinsic reaction coordinate method, and the ...The potential energy surfaces for butanone isomerization have been investigated by density function theory calculation. Six main reaction pathways are confirmed using the intrinsic reaction coordinate method, and the corresponding isomerization products are 1-buten-2-ol, 2-buten-2-ol, butanal or 1-buten-l-ol, methyl 1-propenyl ether, methyl allyl ether, and ethyl vinyl ether, respectively. Among them, there are three pathways through butylene oxide, indicating butylene oxide is an important intermediate product during butanone isomer ization. The calculated vertical ionization energies of the reactant and its products are in a good agreement with the experimental values available. From the consideration for the relative energies Of transition states and the number of high-energy barriers we infer that the reaction pathway butanone-*l-buten-2-ol---2-buten-2-oi is the most competitive. The obtained results are informative for future studies on isomerization of ketone molecules.展开更多
In the modern educational reality, as it is influenced by the social developments, the diversity of school potential is intensely highlighted. At the same time, the standardization of the teaching process appears to b...In the modern educational reality, as it is influenced by the social developments, the diversity of school potential is intensely highlighted. At the same time, the standardization of the teaching process appears to be insufficient to meet the modern instructive requirements, while it is vastly supported that differentiated teaching can sufficiently respond to the modern instructive needs. Moreover, it is pointed out that differentiated teaching is another way of thinking on the instructive work. On that basis and with a view to investigating the functionalist dimensions of differentiated teaching, a research of empiric character was attempted geared toward at the investigation of attitudes and opinions of Greek primary school teachers with regard to the differentiated teaching. The structured questionnaire was used as a research tool and the main conclusions showed not only the limited briefing of the sample teachers, with regard to the theoretical and applicable functionalism of differentiated teaching, but also the conviction that the differentiated teaching has the potential to treat students equally while functioning as a driving force for the dynamic forming of knowledge by the students themselves.展开更多
A virtual reconfigurable architecture(VRA)-based evolvable hardware is proposed for automatic synthesis of combinational logic circuits at gate-level.The proposed VRA is implemented by a Celoxica RC1000 peripheral com...A virtual reconfigurable architecture(VRA)-based evolvable hardware is proposed for automatic synthesis of combinational logic circuits at gate-level.The proposed VRA is implemented by a Celoxica RC1000 peripheral component interconnect(PCI)board with an Xilinx Virtex xcv2000E field programmable gate array(FPGA).To improve the quality of the evolved circuits,the VRA works through a two-stage evolution: finding a functional circuit and minimizing the number of logic gates used in a feasible circuit.To optimize the algorithm performance in the two-stage evolutionary process and set free the user from the time-consuming process of mutation parameter tuning,a self-adaptive mutation rate control(SAMRC)scheme is introduced.In the evolutionary process,the mutation rate control parameters are encoded as additional genes in the chromosome and also undergo evolutionary operations.The efficiency of the proposed methodology is tested with the evolutions of a 4-bit even parity function,a 2-bit multiplier,and a 3-bit multiplier.The obtained results demonstrate that our scheme improves the evolutionary design of combinational logic circuits in terms of quality of the evolved circuit as well as the computational effort,when compared to the existing evolvable hardware approaches.展开更多
Objective: To study the relationship between 14-3-3 sigma gene promoter hypermethylation and its transcrip-tion levels in sporadic breast carcinogenesis. Methods: Hypermethylation of 14-3-3 sigma gene was detected by ...Objective: To study the relationship between 14-3-3 sigma gene promoter hypermethylation and its transcrip-tion levels in sporadic breast carcinogenesis. Methods: Hypermethylation of 14-3-3 sigma gene was detected by sensitive MSP assay in carcinous, non-cancerious and normal tissue, and its mRNA was also detected by real-time PCR based on SYBR Green 1. Results: The hypermethylation frequencies of 14-3-3 sigma were 90% in 68 cases of sporadic breast cancer patients. Hypermethylation was presented in portions (2/13,18%) of hyperplastic samples, and no hypermethylation was presented in normal tissue. The hypermethylation change of 14-3-3 sigma gene was markedly related with various types, grades and lymph node metastases (P < 0.05), and no significant differences in methylation frequencies were seen between premenopause and postmenopause (P > 0.05). The hypermethylation of 14-3-3 sigma showed reverse relationship with its mRNA transcription (P < 0.05). Only lymph node metastases was strongly associated with poor outcome (P = 0.02). Whether 14-3-3 sigma promoter methylation or not did not affect the 5-year survival rate of sporadic breast cancer (P > 0.05). Conclu-sion: Epigenetics alterations of the 14-3-3 sigma can contribute to reducing or losing the expression of 14-3-3 sigma protein, which plays an important role in the development of sporadic breast carcinomas including various types, grades and lymph node metastases.展开更多
基金Supported by the National Basic Research Program of China (2013CB733600), the National Natural Science Foundation of China (21176073), the Doctoral Fund of Ministry of Education of China (20090074110005), the Program for New Century Excellent Talents in University (NCET-09-0346), Shu Guang Project (09SG29) and the Fundamental Research Funds for the Central Universities.
文摘Fault diagnosis and monitoring are very important for complex chemical process. There are numerous methods that have been studied in this field, in which the effective visualization method is still challenging. In order to get a better visualization effect, a novel fault diagnosis method which combines self-organizing map (SOM) with Fisher discriminant analysis (FDA) is proposed. FDA can reduce the dimension of the data in terms of maximizing the separability of the classes. After feature extraction by FDA, SOM can distinguish the different states on the output map clearly and it can also be employed to monitor abnormal states. Tennessee Eastman (TE) process is employed to illustrate the fault diagnosis and monitoring performance of the proposed method. The result shows that the SOM integrated with FDA method is efficient and capable for real-time monitoring and fault diagnosis in complex chemical process.
基金supported by the National Natural Science Foundation of China(21376235)Natural Science Foundation of Liaoning Province(201602740)~~
文摘The synthesis of ferrierite(FER)zeolite using piperidine as an organic structure‐directing agent was investigated.X‐ray diffraction,X‐ray fluorescence,N2‐adsorption,and scanning electron microscopy were used to characterize the crystal phases,textural properties,and particle morphologies of the zeolite samples.The crystallization behavior of the FER zeolite was found to be directly related to crystallization temperature.At150?C,pure FER phase was observed throughout crystallization.At160–170?C,MWW phase appeared first and gradually transformed into FER phase over time,indicating that the FER phase was thermodynamically favored.In the piperidine‐Na2O‐H2O synthetic system,alkalinity proved to be the crucial factor determining the size and textural properties of FER zeolite.Furthermore,the obtained FER samples exhibited good catalytic performance in the skeletal isomerization of1‐butene.
基金Supported by the National Natural Science Foundation of China (20490208)the National High Technology Research and Development Program of China (2007AA030206)the Open Fund of State Key Laboratory of Explosion Science and Technology,BIT (KFJJ06-1)
文摘In this paper, the nitration characteristic of alcohols with mixed acid for the synthesis of energetic mate-rials in a stainless steel microreactor was investigated experimentally. The nitration of iso-octanol with HNO3-H2SO4 mixed acid was chosen as a typical model reaction which involved fast and strong exothermic liquid-liquid heterogeneous reaction process. The influences of mixed acid composition, flow rate, organic/aqueous flow ratio and reaction temperature have been investigated. The results indicated that the reaction could be con-ducted safely and stably in the microreactor at 25-40°C, which are enhanced compared to 15°C or below for safe operating conditions in the conventional reactors. Moreover, the 98.2% conversion of iso-octanol could be obtained and no by-products were detected in all cases.
基金Supported by the Key Discipline Construction of 211 Project IV in China(No.1843202543)Research Innovation Program for College Graduates of Jiangsu Province(No.KYLX15_0728)Science and Technology Program of Jiangsu Province(No.BY2012003)
文摘A preparation process of 2-methylnaphthalene (2-MN) was proposed by isomerization, side-stream distillation and extractive distillation. The isomerization of alkyl naphthalene was catalyzed by acid-treated HBEA zeolites, and the 2-MN selectivity of isomerization was 92.70%. Side-stream distillation and extractive distillation were investigated by simulation, and effects of operation parameters on 2-MN were studied. Further, the simulated results were verified by experiment. Under the optimal condition, the mass fraction of 2-MN reached to 98.09%; in the oroduct, and the yield was 83.84% in refining orocess.
基金supported in part by the National Natural Science Foundation of China under grant No. 61271259, No. 61301123, No. 61471076Scientific and Technological Research Program of Chongqing Municipal Education Commission of Chongqing of China under Grant No.KJ130536
文摘In order to solve the problem the existing vertical handoff algorithms of vehicle heterogeneous wireless network do not consider the diversification of network's status, an optimized vertical handoff algorithm based on markov process is proposed and discussed in this paper. This algorithm takes into account that the status transformation of available network will affect the quality of service(Qo S) of vehicle terminal's communication service. Firstly, Markov process is used to predict the transformation of wireless network's status after the decision via transition probability. Then the weights of evaluating parameters will be determined by fuzzy logic method. Finally, by comparing the total incomes of each wireless network, including handoff decision incomes, handoff execution incomes and communication service incomes after handoff, the optimal network to handoff will be selected. Simulation results show that: the algorithm proposed, compared to the existing algorithm, is able to receive a higher level of load balancing and effectively improves the average blocking rate, packet loss rate and ping-pang effect.
文摘The present work contributed to a new developed production method for enhancing the quality of isoamylene (IA) by adding a small amount of tertiary amyl alcohol (TAA) to the catalyst of strong acid cation exchange resin. TAA improved the selectivity of 2-methyl-2-butene (2M2B) at a high conversion level for the isomerization of IA. Compared with the other results from the current IA units, the conversion of 2-methyl- 1-butene (2M1B), the mass ratio of 2M2B to 2M1B and the selectivity of 2M2B were increased from 0.5474, 7.32 and 0.6864 to 0.72, 12 and 0.95, respectively, while the dimers content in the products decreased from 4.38% to below 1.0%. Optimized conditions for IA isomerization consisted of temperature between 28 and 33℃ and system pressure of 0.5 MPa, weight hourly space velocity of 8.0 h-1 with TAA mass fraction of 0.7%-0.9% in raw material. The results in lab supported bases for the developed process in industrial application which was later proved to be successful. In addition, a possible mechanism of the isomerization process was speculated to propose a key step of water formation in the TAA-added isomerization process and a verified experiment was conducted to support this speculation.
文摘The potential energy surfaces for butanone isomerization have been investigated by density function theory calculation. Six main reaction pathways are confirmed using the intrinsic reaction coordinate method, and the corresponding isomerization products are 1-buten-2-ol, 2-buten-2-ol, butanal or 1-buten-l-ol, methyl 1-propenyl ether, methyl allyl ether, and ethyl vinyl ether, respectively. Among them, there are three pathways through butylene oxide, indicating butylene oxide is an important intermediate product during butanone isomer ization. The calculated vertical ionization energies of the reactant and its products are in a good agreement with the experimental values available. From the consideration for the relative energies Of transition states and the number of high-energy barriers we infer that the reaction pathway butanone-*l-buten-2-ol---2-buten-2-oi is the most competitive. The obtained results are informative for future studies on isomerization of ketone molecules.
文摘In the modern educational reality, as it is influenced by the social developments, the diversity of school potential is intensely highlighted. At the same time, the standardization of the teaching process appears to be insufficient to meet the modern instructive requirements, while it is vastly supported that differentiated teaching can sufficiently respond to the modern instructive needs. Moreover, it is pointed out that differentiated teaching is another way of thinking on the instructive work. On that basis and with a view to investigating the functionalist dimensions of differentiated teaching, a research of empiric character was attempted geared toward at the investigation of attitudes and opinions of Greek primary school teachers with regard to the differentiated teaching. The structured questionnaire was used as a research tool and the main conclusions showed not only the limited briefing of the sample teachers, with regard to the theoretical and applicable functionalism of differentiated teaching, but also the conviction that the differentiated teaching has the potential to treat students equally while functioning as a driving force for the dynamic forming of knowledge by the students themselves.
基金Projects(61203308,61309014)supported by the National Natural Science Foundation of China
文摘A virtual reconfigurable architecture(VRA)-based evolvable hardware is proposed for automatic synthesis of combinational logic circuits at gate-level.The proposed VRA is implemented by a Celoxica RC1000 peripheral component interconnect(PCI)board with an Xilinx Virtex xcv2000E field programmable gate array(FPGA).To improve the quality of the evolved circuits,the VRA works through a two-stage evolution: finding a functional circuit and minimizing the number of logic gates used in a feasible circuit.To optimize the algorithm performance in the two-stage evolutionary process and set free the user from the time-consuming process of mutation parameter tuning,a self-adaptive mutation rate control(SAMRC)scheme is introduced.In the evolutionary process,the mutation rate control parameters are encoded as additional genes in the chromosome and also undergo evolutionary operations.The efficiency of the proposed methodology is tested with the evolutions of a 4-bit even parity function,a 2-bit multiplier,and a 3-bit multiplier.The obtained results demonstrate that our scheme improves the evolutionary design of combinational logic circuits in terms of quality of the evolved circuit as well as the computational effort,when compared to the existing evolvable hardware approaches.
基金Supported by a grant from the Natural Sciences Foundation of Hubei Province (No. 2007ABA371).
文摘Objective: To study the relationship between 14-3-3 sigma gene promoter hypermethylation and its transcrip-tion levels in sporadic breast carcinogenesis. Methods: Hypermethylation of 14-3-3 sigma gene was detected by sensitive MSP assay in carcinous, non-cancerious and normal tissue, and its mRNA was also detected by real-time PCR based on SYBR Green 1. Results: The hypermethylation frequencies of 14-3-3 sigma were 90% in 68 cases of sporadic breast cancer patients. Hypermethylation was presented in portions (2/13,18%) of hyperplastic samples, and no hypermethylation was presented in normal tissue. The hypermethylation change of 14-3-3 sigma gene was markedly related with various types, grades and lymph node metastases (P < 0.05), and no significant differences in methylation frequencies were seen between premenopause and postmenopause (P > 0.05). The hypermethylation of 14-3-3 sigma showed reverse relationship with its mRNA transcription (P < 0.05). Only lymph node metastases was strongly associated with poor outcome (P = 0.02). Whether 14-3-3 sigma promoter methylation or not did not affect the 5-year survival rate of sporadic breast cancer (P > 0.05). Conclu-sion: Epigenetics alterations of the 14-3-3 sigma can contribute to reducing or losing the expression of 14-3-3 sigma protein, which plays an important role in the development of sporadic breast carcinomas including various types, grades and lymph node metastases.