Objective： To investigate the effects of carvedilol （CVD） on transmural dispersion of repolarization（TDR） and arrhythmia in pressure over-load rabbits. Methods： Left ventricular hypertrophied（LVH） rabbit model...Objective： To investigate the effects of carvedilol （CVD） on transmural dispersion of repolarization（TDR） and arrhythmia in pressure over-load rabbits. Methods： Left ventricular hypertrophied（LVH） rabbit models were established by pressure over-load; All animal models were assigned into CVD group or LVH group randomly. The action potentials of endocardium, cpicardium and transmural ECG of arterially perfused left ventricular preparations were recorded concurrently. Action potential duration （APD）, TDR, ventricular arrhythmia and ultrasonic parameters, ratio of LVM to body weight （LVMI） were compared correspondingly. The stable plasma concentration of carvedilol in CVD group was detected by HPLC. APD, TDR and arrhythmia of LVH models were compared just preor post-perfusion with stable concentration of CVD. Results： In Contrast with values in LVH group, LVEFof CVD group were significantly elevated while the LVMI was remarkably reduced, TDRs were significantly shortened, and ratio of ventricular arrhythmia was lowered remarkably. No significant difference of APD, TDR and ratio of arrhythmia was found preor post-perfusion at stable plasma concentration of CVD. Conclusion： CVD can ameliorate the structure and function of pressure over-load ventricles; CVD contributes to the improvement of ventricular arrhythmia associated with its long-term effect on APD,TDR shortening ,whereas has nothing to do with its transient function on ionic channel blockade展开更多
The effect of test methods and stress paths on the experimental value of the coefficient of earth pressure at rest, K0, was investigated under high pressures. The results indicate that the rigid pressure chamber and f...The effect of test methods and stress paths on the experimental value of the coefficient of earth pressure at rest, K0, was investigated under high pressures. The results indicate that the rigid pressure chamber and flexible lateral confining pressure medium method gives a stress ratio at the initial stage that is not the real K0. Moreover, K0 increases during the loading process becoming greater at high pressures. In the unloading process, however, K0 increases only at the initial stage but decreases thereafter. In addition, the incremental magnitude definition, K0=dσ3/dσ1, gives higher values than the total magnitude definition, K0=σ3/σ1, under loading. This is also true during initial stages of unloading. The experiment results also indicate that earth pressure at rest in deep and thick soils can be estimated by a power function of axial and confining pressures. It is necessary to choose the appropriate Kn to avoid some accidents.展开更多
In order to reveal the law of raw coal seepage at different gas pressures, the gravity constant load seepage experimental system was developed and used. The law of raw coal seepage at different gas pressures with He, ...In order to reveal the law of raw coal seepage at different gas pressures, the gravity constant load seepage experimental system was developed and used. The law of raw coal seepage at different gas pressures with He, N2 and CO2 was investigated. The results show that, in a given state of stress during the experiment, with the increase of gas pressure, the permeability of raw coal sample prone to outburst exhibits a significantly decrease, and then exhibits an increasing trend when reaching the extreme point. The law of Klingberg coefficient related to the stress state and the gas adsorption properties was also obtained. Under the same experimental conditions, the Klingberg coefficient of He is greater than that of N2; and the Klingberg coefficient of CO2 has minimum value; so the stronger the gas adsorption is, the smaller the Klingberg coefficient of gas goes. Klinkenberg coefficient decreases with the increase of effective stress. Under the same conditions, the permeability of He is greater than that of N2; the permeability of CO2 has minimum value; so the stronger the gas adsorption is, the lower the permeability of the coal sample goes. The results have important significance in revealing the mechanism of gas seenage. Dredicting coal mine gas disaster, and gas drainage and safety nroduction.展开更多
文摘Objective： To investigate the effects of carvedilol （CVD） on transmural dispersion of repolarization（TDR） and arrhythmia in pressure over-load rabbits. Methods： Left ventricular hypertrophied（LVH） rabbit models were established by pressure over-load; All animal models were assigned into CVD group or LVH group randomly. The action potentials of endocardium, cpicardium and transmural ECG of arterially perfused left ventricular preparations were recorded concurrently. Action potential duration （APD）, TDR, ventricular arrhythmia and ultrasonic parameters, ratio of LVM to body weight （LVMI） were compared correspondingly. The stable plasma concentration of carvedilol in CVD group was detected by HPLC. APD, TDR and arrhythmia of LVH models were compared just preor post-perfusion with stable concentration of CVD. Results： In Contrast with values in LVH group, LVEFof CVD group were significantly elevated while the LVMI was remarkably reduced, TDRs were significantly shortened, and ratio of ventricular arrhythmia was lowered remarkably. No significant difference of APD, TDR and ratio of arrhythmia was found preor post-perfusion at stable plasma concentration of CVD. Conclusion： CVD can ameliorate the structure and function of pressure over-load ventricles; CVD contributes to the improvement of ventricular arrhythmia associated with its long-term effect on APD,TDR shortening ,whereas has nothing to do with its transient function on ionic channel blockade
基金Projects 50534040 supported by the National Natural Science Foundation of ChinaBK2007040 by the Natural Science Foundation of Jiangsu ProvinceCX08B_103Z by the Post Graduate Research Projects of Jiangsu Province
文摘The effect of test methods and stress paths on the experimental value of the coefficient of earth pressure at rest, K0, was investigated under high pressures. The results indicate that the rigid pressure chamber and flexible lateral confining pressure medium method gives a stress ratio at the initial stage that is not the real K0. Moreover, K0 increases during the loading process becoming greater at high pressures. In the unloading process, however, K0 increases only at the initial stage but decreases thereafter. In addition, the incremental magnitude definition, K0=dσ3/dσ1, gives higher values than the total magnitude definition, K0=σ3/σ1, under loading. This is also true during initial stages of unloading. The experiment results also indicate that earth pressure at rest in deep and thick soils can be estimated by a power function of axial and confining pressures. It is necessary to choose the appropriate Kn to avoid some accidents.
基金supported by the Fundamental Research Funds for the Central Universities (No. 2011QZ02)the National Natural Science Foundation of China (No. 51204189)the National Basic Research Program of China (No. 2011CB201202)
文摘In order to reveal the law of raw coal seepage at different gas pressures, the gravity constant load seepage experimental system was developed and used. The law of raw coal seepage at different gas pressures with He, N2 and CO2 was investigated. The results show that, in a given state of stress during the experiment, with the increase of gas pressure, the permeability of raw coal sample prone to outburst exhibits a significantly decrease, and then exhibits an increasing trend when reaching the extreme point. The law of Klingberg coefficient related to the stress state and the gas adsorption properties was also obtained. Under the same experimental conditions, the Klingberg coefficient of He is greater than that of N2; and the Klingberg coefficient of CO2 has minimum value; so the stronger the gas adsorption is, the smaller the Klingberg coefficient of gas goes. Klinkenberg coefficient decreases with the increase of effective stress. Under the same conditions, the permeability of He is greater than that of N2; the permeability of CO2 has minimum value; so the stronger the gas adsorption is, the lower the permeability of the coal sample goes. The results have important significance in revealing the mechanism of gas seenage. Dredicting coal mine gas disaster, and gas drainage and safety nroduction.
