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Sixteen Years of Trastuzumab Use: Complete Response in Lung, Bone, and CNS Metastasis from Breast Cancer
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作者 Maria de Lourdes Lopes de Oliveira Oliveira and Gabriela Passos 《Journal of Pharmacy and Pharmacology》 2017年第5期270-274,共5页
Although metastatic breast cancer is considered as an incurable disease, various biological drivers influence the outcomes. The use of trastuzumab in patients overexpressing HER(human epidermal growth factor recepto... Although metastatic breast cancer is considered as an incurable disease, various biological drivers influence the outcomes. The use of trastuzumab in patients overexpressing HER(human epidermal growth factor receptor 2)-2 increases long-term survival even in those patients who developed brain metastasis. Nevertheless, special attention must be paid to the risk of cardiotoxicity. We report the case of a young woman with HER-2-positive breast cancer with bone and lung disease who developed brain metastasis during treatment with trastuzumab. The treatment has been continued and she is alive and in complete remission after 16 years. 展开更多
关键词 TRASTUZUMAB long-term survival brain metastasis complete response breast cancer.
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气相爆轰波马赫反射影响因素的实验研究
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作者 刘杰 杜忠华 《高压物理学报》 CAS CSCD 北大核心 2016年第1期55-63,共9页
在矩形截面的爆轰管道中,对C2H2+2.5O2+8.17Ar和C2H2+5N2O在CJ爆轰状态下经过不同楔面所发生的马赫反射的影响因素进行了实验研究。实验中,由烟膜记录爆轰波马赫反射的胞格结构转变过程;采用纹影技术捕捉爆轰波马赫反射波阵面的不稳定... 在矩形截面的爆轰管道中,对C2H2+2.5O2+8.17Ar和C2H2+5N2O在CJ爆轰状态下经过不同楔面所发生的马赫反射的影响因素进行了实验研究。实验中,由烟膜记录爆轰波马赫反射的胞格结构转变过程;采用纹影技术捕捉爆轰波马赫反射波阵面的不稳定性及波后流场分布。实验结果表明:两种实验气体在爆轰波马赫反射过程中均存在由CJ区域向过驱区域转变的胞格结构;初始压力对楔面与马赫反射三波点轨迹线之间的夹角(χ)影响明显,楔角θw对χ的影响随θw的增大而增大;根据实验测得的θw+χ与θw之间的关系,可知爆轰波马赫反射三波点轨迹线的斜率随着θw的增大而增大,与CJ区域内胞格轨迹线的相交距离也更短,使马赫杆后的过驱度升高。另外,不稳定气体C2H2+5N2O的不稳定性高于稳定气体C2H2+2.5O2+8.17Ar,导致二者的爆轰波马赫反射行为存在较大的差异。 展开更多
关键词 气相爆轰 马赫反射 胞格结构 诱导区 过驱度
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Ergodicity of stochastic Boussinesq equations driven by Lvy processes
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作者 ZHENG Yan HUANG JianHua 《Science China Mathematics》 SCIE 2013年第6期1195-1212,共18页
We consider a class of stochastic Boussinesq equations driven by L6vy processes and establish the uniqueness of its invariant measure. The proof is based on the progressive stopping time technique.
关键词 Boussinesq equations Levy process invariant measure ERGODICITY
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