背景:运用组织工程方法修复骨损伤近年来研究的热点。目的:综述骨组织工程学研究现状以及亟待解决的关键问题。方法:以"组织工程学,运动性骨损伤,生物支架材料,骨的血管化,种子细胞"为中文关键词,"Tissue engineering,Sp...背景:运用组织工程方法修复骨损伤近年来研究的热点。目的:综述骨组织工程学研究现状以及亟待解决的关键问题。方法:以"组织工程学,运动性骨损伤,生物支架材料,骨的血管化,种子细胞"为中文关键词,"Tissue engineering,Sports bone damage,Biological material scaffold;Vascularized bone;Seed cells"为英文关键词,检索1994-01/2010-12PubMed数据库与维普数据库相关文章。结果与结论:尽管组织工程学修复骨缺损已取得很大的成就,但真正应用于临床创伤缺损修复还有很多问题需要解决:如何解决种子细胞易老化,表型易丧失的问题;如何增强细胞与支架材料的亲和力;如何为替代组织提供良好的血供与神经支配;如何更逼真地模拟人体内环境,使培养的细胞和预制成的组织器官在体内也能经受住考验;如何降低免疫反应等。展开更多
Micro- injury （exercise-induced muscle damage, EIMD） will cause a temporary decline in muscle function, if not handled properly, it could cause more serious injury or overtraining, and even lead to the end of the at...Micro- injury （exercise-induced muscle damage, EIMD） will cause a temporary decline in muscle function, if not handled properly, it could cause more serious injury or overtraining, and even lead to the end of the athletes ＇ sports life. However, some studies have shown that an appropriate period of eccentric exercise training resulted in EIMD while promoted heart muscle fiber hypertrophy and corresponding muscle growth faster than exercise training, and there are the typical ＂ repetitive training effect＂ , ie after a period of the EIMD recovery, the muscle＇ s injury or delayed onset muscle soreness （DOMS） caused by the same movement is significantly reduced. So its deep study could help to guide the athlete to avoid or mitigate the negative effects which brought by EIMD, while could help to further clarify the process of the body to adapt to exercise training or mechanism.展开更多
文摘背景:运用组织工程方法修复骨损伤近年来研究的热点。目的:综述骨组织工程学研究现状以及亟待解决的关键问题。方法:以"组织工程学,运动性骨损伤,生物支架材料,骨的血管化,种子细胞"为中文关键词,"Tissue engineering,Sports bone damage,Biological material scaffold;Vascularized bone;Seed cells"为英文关键词,检索1994-01/2010-12PubMed数据库与维普数据库相关文章。结果与结论:尽管组织工程学修复骨缺损已取得很大的成就,但真正应用于临床创伤缺损修复还有很多问题需要解决:如何解决种子细胞易老化,表型易丧失的问题;如何增强细胞与支架材料的亲和力;如何为替代组织提供良好的血供与神经支配;如何更逼真地模拟人体内环境,使培养的细胞和预制成的组织器官在体内也能经受住考验;如何降低免疫反应等。
文摘从功能内稳态(function-specific homeostasis,FSH)角度分析EIMD/DOMS过程影响运动成绩的正常发挥,而防治措施又大多无效这一现象,结果发现力竭运动所致的EIMD/DOMS,骨骼肌蛋白质代谢远离了蛋白质代谢内稳态(protein metabolite specific homeostasis,PmSH),EIMD/DOMS康复延迟,外源性有利因素干预可促进EIMD/DOMS康复;非力竭运动所致的EIMD/DOMS,蛋白质代谢处于PmSH,EIMD/DOMS正常康复,外源性因素对EIMD/DOMS无明显影响作用。
文摘Micro- injury （exercise-induced muscle damage, EIMD） will cause a temporary decline in muscle function, if not handled properly, it could cause more serious injury or overtraining, and even lead to the end of the athletes ＇ sports life. However, some studies have shown that an appropriate period of eccentric exercise training resulted in EIMD while promoted heart muscle fiber hypertrophy and corresponding muscle growth faster than exercise training, and there are the typical ＂ repetitive training effect＂ , ie after a period of the EIMD recovery, the muscle＇ s injury or delayed onset muscle soreness （DOMS） caused by the same movement is significantly reduced. So its deep study could help to guide the athlete to avoid or mitigate the negative effects which brought by EIMD, while could help to further clarify the process of the body to adapt to exercise training or mechanism.
