Parkinson's disease(PD) is the most common neurodegenerative movement disorder, affecting about 1% of the population above the age of 65. PD is characterized by a selective degeneration of the dopaminergic neurons...Parkinson's disease(PD) is the most common neurodegenerative movement disorder, affecting about 1% of the population above the age of 65. PD is characterized by a selective degeneration of the dopaminergic neurons of the substantia nigra pars compacta. This results in a marked loss of striatal dopamine and the development of the characteristic features of the disease, i.e., bradykinesia, rest tremor, rigidity, gait abnormalities and postural instability. Other types of neurons/neurotransmitters are also involved in PD, including cholinergic, serotonergic, glutamatergic, adenosine, and GABAergic neurotransmission which might have relevance to the motor, non-motor, neuro-psychiatric and cognitive disturbances that occur in the course of the disease. The treatment of PD relies on replacement therapy with levodopa(L-dopa), the precursor of dopamine, in combination with a peripheral decarboxylase inhibitor(carbidopa or benserazide). The effect of L-dopa, however, declines over time together with the development of motor complications especially dyskinesia in a significant proportion of patients within 5 years of therapy. Other drugs include dopaminereceptor-agonists, catechol-O-methyltransferase inhibitors, monoamine oxidase type B(MAO-B) inhibitors, anticholinergics and adjuvant therapy with the antiviral drug and the N-methyl-D-aspartate glutamate receptor antagonist amantadine. Although, these medications can result in substantial improvements in parkinsonian symptoms, especially during the early stages of the disease, they are often not successful in advanced disease. Moreover, dopaminergic cell death continues over time, emphasizing the need for neuroprotective or neuroregenerative therapies. In recent years, research has focused on non-dopaminergic approach such as the use of A2 A receptor antagonists: istradefylline and preladenant or the calcium channel antagonist isradipine. Safinamide is a selective and reversible inhibitor of MAO-B, a glutamate receptor inhibitor as well as sodium and calcium channel blocker. Minocycline and pioglitazone are other agents which have been shown to prevent dopaminergic nigral cell loss in animal models of PD. There is also an evidence to suggest a benefit from iron chelation therapy with deferiprone and from the use of antioxidants or mitochondrial function enhancers such as creatine, alpha-lipoic acid, l-carnitine, and coenzyme Q10.展开更多
cases suffering from different kinds of headache were treated by the authors with scalp acupuncture with movement. The results of instant and long term therapeutic effects show that the scalp acupuncture with movement...cases suffering from different kinds of headache were treated by the authors with scalp acupuncture with movement. The results of instant and long term therapeutic effects show that the scalp acupuncture with movement is a simple and effective skill. The instant therapeutic effects: the headache in 163 cases disappeared; in 9 cases the effect was quite obvious; and in 7 cases it was effective; the total effective rate amounted to 98.9%. The long term therapeutic effects: 135 cases (74.6%) were cured. The toral effective rate was 77.2%.展开更多
Objective:To compare therapeutic effects of acupuncture at Ligou(LR 5) plus movement therapy and conventional acupuncture on cervical spondylosis.Methods:The therapeutic effect of acupuncture at Ligou(LR 5) plus movem...Objective:To compare therapeutic effects of acupuncture at Ligou(LR 5) plus movement therapy and conventional acupuncture on cervical spondylosis.Methods:The therapeutic effect of acupuncture at Ligou(LR 5) plus movement therapy on 57 cases of cervical spondylosis(Group Acup.+M) was observed and compared with that of conventional acupuncture(Group Acup.) on 65 cases of cervical spondylosis with the same types of the disease during the same observation period as those treated by the former therapy.Results:The cured rate,effective rate and total effective rate were 52.63%,45.61% and 98.24%,respectively in Group Acup.+M;46.15%,50.77% and 96.92%,respectively in Group Acup.There were no significant differences in therapeutic effects between the two groups,shown by Ridit test(P>0.05).Conclusion:Both acupuncture plus movement therapy and conventional acupuncture were similarly effective in treating cervical spondylosis,but the former was superior to the latter in shorter treatment course and fewer points used.展开更多
Acute lumbar sprain is a common symptom in acupuncture and moxibustion department. It is acute laceration induced by over traction of soft tissues, such as lumbar muscle, fascia and ligament due to external exertions....Acute lumbar sprain is a common symptom in acupuncture and moxibustion department. It is acute laceration induced by over traction of soft tissues, such as lumbar muscle, fascia and ligament due to external exertions. Lumbar pain is typical in clinic. The pain is drastic, persistent, with fixed location and combined with limited motor function. It is termed as ＂Shan Yao＂ （闪腰） and ＂Cha Qi＂ （ 岔气 ） in TCM.展开更多
Objective To explore the clinical efficacy of spine subtle adjusting manipulation for postpartum low back pain(PLBP).Methods A total of 76 patients with PLBP were randomized into a control group and a treatment group,...Objective To explore the clinical efficacy of spine subtle adjusting manipulation for postpartum low back pain(PLBP).Methods A total of 76 patients with PLBP were randomized into a control group and a treatment group,with 38 cases in each group.The control group was treated with core muscle strengthening exercises,and the treatment group was treated with spine subtle adjusting manipulation.After 3 weeks of treatment,the clinical efficacy was observed,and the visual analog scale(VAS)score and Oswestry disability index(ODI),and the changes of lumbar Cobb angle and pelvic rotation were compared between the two groups.Results The total effective rate of the treatment group was 92.1%,and that of the control group was 78.9%.The difference between the two groups was statistically significant(P<0.05).After treatment,the VAS score and ODI in both groups decreased,and the intra-group differences were all statistically significant(P<0.05).There were no intra-group statistical differences in the lumbar Cobb angle or pelvic rotation in the two groups(P>0.05).After treatment,there were no statistical differences in the lumbar Cobb angle or pelvic rotation between the two groups(P>0.05);the VAS score and ODI in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Spine subtle adjusting manipulation can effectively relieve the pain for patients with PLBP,and improve their daily activity function.展开更多
文摘Parkinson's disease(PD) is the most common neurodegenerative movement disorder, affecting about 1% of the population above the age of 65. PD is characterized by a selective degeneration of the dopaminergic neurons of the substantia nigra pars compacta. This results in a marked loss of striatal dopamine and the development of the characteristic features of the disease, i.e., bradykinesia, rest tremor, rigidity, gait abnormalities and postural instability. Other types of neurons/neurotransmitters are also involved in PD, including cholinergic, serotonergic, glutamatergic, adenosine, and GABAergic neurotransmission which might have relevance to the motor, non-motor, neuro-psychiatric and cognitive disturbances that occur in the course of the disease. The treatment of PD relies on replacement therapy with levodopa(L-dopa), the precursor of dopamine, in combination with a peripheral decarboxylase inhibitor(carbidopa or benserazide). The effect of L-dopa, however, declines over time together with the development of motor complications especially dyskinesia in a significant proportion of patients within 5 years of therapy. Other drugs include dopaminereceptor-agonists, catechol-O-methyltransferase inhibitors, monoamine oxidase type B(MAO-B) inhibitors, anticholinergics and adjuvant therapy with the antiviral drug and the N-methyl-D-aspartate glutamate receptor antagonist amantadine. Although, these medications can result in substantial improvements in parkinsonian symptoms, especially during the early stages of the disease, they are often not successful in advanced disease. Moreover, dopaminergic cell death continues over time, emphasizing the need for neuroprotective or neuroregenerative therapies. In recent years, research has focused on non-dopaminergic approach such as the use of A2 A receptor antagonists: istradefylline and preladenant or the calcium channel antagonist isradipine. Safinamide is a selective and reversible inhibitor of MAO-B, a glutamate receptor inhibitor as well as sodium and calcium channel blocker. Minocycline and pioglitazone are other agents which have been shown to prevent dopaminergic nigral cell loss in animal models of PD. There is also an evidence to suggest a benefit from iron chelation therapy with deferiprone and from the use of antioxidants or mitochondrial function enhancers such as creatine, alpha-lipoic acid, l-carnitine, and coenzyme Q10.
文摘cases suffering from different kinds of headache were treated by the authors with scalp acupuncture with movement. The results of instant and long term therapeutic effects show that the scalp acupuncture with movement is a simple and effective skill. The instant therapeutic effects: the headache in 163 cases disappeared; in 9 cases the effect was quite obvious; and in 7 cases it was effective; the total effective rate amounted to 98.9%. The long term therapeutic effects: 135 cases (74.6%) were cured. The toral effective rate was 77.2%.
基金supported by a grant from National Natural Science Foundation of China (No 30772839, No30873302)
文摘Objective:To compare therapeutic effects of acupuncture at Ligou(LR 5) plus movement therapy and conventional acupuncture on cervical spondylosis.Methods:The therapeutic effect of acupuncture at Ligou(LR 5) plus movement therapy on 57 cases of cervical spondylosis(Group Acup.+M) was observed and compared with that of conventional acupuncture(Group Acup.) on 65 cases of cervical spondylosis with the same types of the disease during the same observation period as those treated by the former therapy.Results:The cured rate,effective rate and total effective rate were 52.63%,45.61% and 98.24%,respectively in Group Acup.+M;46.15%,50.77% and 96.92%,respectively in Group Acup.There were no significant differences in therapeutic effects between the two groups,shown by Ridit test(P>0.05).Conclusion:Both acupuncture plus movement therapy and conventional acupuncture were similarly effective in treating cervical spondylosis,but the former was superior to the latter in shorter treatment course and fewer points used.
文摘Acute lumbar sprain is a common symptom in acupuncture and moxibustion department. It is acute laceration induced by over traction of soft tissues, such as lumbar muscle, fascia and ligament due to external exertions. Lumbar pain is typical in clinic. The pain is drastic, persistent, with fixed location and combined with limited motor function. It is termed as ＂Shan Yao＂ （闪腰） and ＂Cha Qi＂ （ 岔气 ） in TCM.
文摘Objective To explore the clinical efficacy of spine subtle adjusting manipulation for postpartum low back pain(PLBP).Methods A total of 76 patients with PLBP were randomized into a control group and a treatment group,with 38 cases in each group.The control group was treated with core muscle strengthening exercises,and the treatment group was treated with spine subtle adjusting manipulation.After 3 weeks of treatment,the clinical efficacy was observed,and the visual analog scale(VAS)score and Oswestry disability index(ODI),and the changes of lumbar Cobb angle and pelvic rotation were compared between the two groups.Results The total effective rate of the treatment group was 92.1%,and that of the control group was 78.9%.The difference between the two groups was statistically significant(P<0.05).After treatment,the VAS score and ODI in both groups decreased,and the intra-group differences were all statistically significant(P<0.05).There were no intra-group statistical differences in the lumbar Cobb angle or pelvic rotation in the two groups(P>0.05).After treatment,there were no statistical differences in the lumbar Cobb angle or pelvic rotation between the two groups(P>0.05);the VAS score and ODI in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Spine subtle adjusting manipulation can effectively relieve the pain for patients with PLBP,and improve their daily activity function.
