Aims: The heritability of aerobic power and of the response to physical training has been shown in healthy subjects. β 1-Adrenergic receptor(β 1AR) function affects exercise performance. This study aims to investiga...Aims: The heritability of aerobic power and of the response to physical training has been shown in healthy subjects. β 1-Adrenergic receptor(β 1AR) function affects exercise performance. This study aims to investigate whether the Ser49Gly and Gly389Arg polymorphisms of the β 1AR gene or their haplotypes are associated with aerobic power or its response to physical training in coronary artery disease(CAD). Methods and results: Nine hundred and thirty-five biologically unrelated Caucasian patients with CAD who had exercised until exhaustion during graded bicycle testing at baseline and after completion of 3 months of exercise training from 1990 to 2001(n=1095) were eligible for inclusion in the CAREGENE(CArdiac REhabilitation and GENetics of Exercise performance) study. Polymorphisms were detected using the invader assay(ThirdWave TechnologiesTM,Madison,Wisconsin, USA). Patients with the Gly49Gly genotype had significantly higher covariate-adjusted aerobic power at baseline than those with Ser49Ser and Ser49Gly(P< 0.05). Adjusted aerobic power at baseline was highest in the Ser49-Gly389/Gly49-Gly389 and Gly49-Arg389/Gly49-Arg389 haplotype combinations. Aerobic power increased significantly(P< 0.001) with physical training. There was no association with the effect of physical training. Conclusion: Ser49Gly and haplotype combinations of Ser49Gly and Gly389Arg of the β 1AR gene are associated with aerobic power, but not with the response to physical training in patients with CAD included in the CAREGENE study.展开更多
This paper summarizes the ratio of 2D and 4D to the inheritance of athletic ability： 2D： 4D has been stereotypes before birth, and the mother＇s uterus testosterone concentration there is a negative correlation betw...This paper summarizes the ratio of 2D and 4D to the inheritance of athletic ability： 2D： 4D has been stereotypes before birth, and the mother＇s uterus testosterone concentration there is a negative correlation between the relationship, Testosterone concentration affects the development of the right hemisphere and spatial visual ability of the brain, thus affecting athletic ability. The mitochondrial genome （mtDNA） polymorphism is directly related to motor activity and has a high maternal genetic trait. Athlete mothers have higher testosterone, and their children have athletic advantages. 2D： 4D and mtDNA have good genetic markers, which are of great significance and prospect for the study of their inheritance of motor ability.展开更多
文摘Aims: The heritability of aerobic power and of the response to physical training has been shown in healthy subjects. β 1-Adrenergic receptor(β 1AR) function affects exercise performance. This study aims to investigate whether the Ser49Gly and Gly389Arg polymorphisms of the β 1AR gene or their haplotypes are associated with aerobic power or its response to physical training in coronary artery disease(CAD). Methods and results: Nine hundred and thirty-five biologically unrelated Caucasian patients with CAD who had exercised until exhaustion during graded bicycle testing at baseline and after completion of 3 months of exercise training from 1990 to 2001(n=1095) were eligible for inclusion in the CAREGENE(CArdiac REhabilitation and GENetics of Exercise performance) study. Polymorphisms were detected using the invader assay(ThirdWave TechnologiesTM,Madison,Wisconsin, USA). Patients with the Gly49Gly genotype had significantly higher covariate-adjusted aerobic power at baseline than those with Ser49Ser and Ser49Gly(P< 0.05). Adjusted aerobic power at baseline was highest in the Ser49-Gly389/Gly49-Gly389 and Gly49-Arg389/Gly49-Arg389 haplotype combinations. Aerobic power increased significantly(P< 0.001) with physical training. There was no association with the effect of physical training. Conclusion: Ser49Gly and haplotype combinations of Ser49Gly and Gly389Arg of the β 1AR gene are associated with aerobic power, but not with the response to physical training in patients with CAD included in the CAREGENE study.
文摘This paper summarizes the ratio of 2D and 4D to the inheritance of athletic ability： 2D： 4D has been stereotypes before birth, and the mother＇s uterus testosterone concentration there is a negative correlation between the relationship, Testosterone concentration affects the development of the right hemisphere and spatial visual ability of the brain, thus affecting athletic ability. The mitochondrial genome （mtDNA） polymorphism is directly related to motor activity and has a high maternal genetic trait. Athlete mothers have higher testosterone, and their children have athletic advantages. 2D： 4D and mtDNA have good genetic markers, which are of great significance and prospect for the study of their inheritance of motor ability.
