目的探讨脑桥旁正中梗死急性期运动功能缺损进展(progressive motor deficits,PMDs)的危险因素。方法2017年12月至2020年12月,在本院连续入组发病24 h内的脑桥梗死患者。入院后1周内每日行美国国立卫生院卒中量表(National Institutes o...目的探讨脑桥旁正中梗死急性期运动功能缺损进展(progressive motor deficits,PMDs)的危险因素。方法2017年12月至2020年12月,在本院连续入组发病24 h内的脑桥梗死患者。入院后1周内每日行美国国立卫生院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分,若其中运动项目评分较入院增加≥1分则纳入进展组,反之为非进展组。比较两组患者人口统计学、临床资料和影像学特征,采用单因素分析及多因素logistic回归分析。结果共纳入脑桥旁正中梗死患者109例,31例出现PMDs。单因素分析提示:进展组与非进展组在入院时吞咽障碍[14(45.1%)vs.14(17.9%)]、最大梗死灶位置处于脑桥下部[19(61.3%)vs.25(32.1%)]、病灶累及腹侧[19(61.3%)vs.22(28.2%)]及病因分型[小动脉疾病11(35.5%)vs.52(66.7%)、基底动脉分支动脉疾病16(51.6%)vs.19(24.4%)]方面,差异具有统计学意义(P<0.05)。多因素logistic回归分析提示病灶累及脑桥腹侧(OR=3.453,95%CI:1.402~8.505,P=0.007)、最大梗死灶位置处于脑桥下部(OR=2.795,95%CI:1.134~6.887,P=0.026)是发生PMDs的危险因素。结论病灶累及脑桥腹侧、最大梗死灶位置处于脑桥下部可预测脑桥旁正中梗死患者运动缺损进展。展开更多
Since nuclear extrusion was rediscovered in young Allium scale by S.H.WU in the years of 1950's systematic investigations on this phenomenon were carried out with various kinds of microscopic techniques a...Since nuclear extrusion was rediscovered in young Allium scale by S.H.WU in the years of 1950's systematic investigations on this phenomenon were carried out with various kinds of microscopic techniques and plant materials to collect more effective evidence to clarify the debate about whether the nuclear extrusion is an artifact or normal event. In the cooperative research of S. H. WU and C. H. LOU the normality of the occurrence of nuclear extrusion either in growing part of plant or in senescent tissue has been confirmed. This event is intimately associated with the physiological state of the tissues/cells and may play an important role in redistribution and reutilization of cell contents. Based on the results obtained a hypothesis of intercellular movement of protoplasm as a means of translocation of organic material in plants was suggested. Chromatin extrusion was also discovered in the pollen mother cells (cytomixis) of certain angiosperms by G. C. ZHENG and his team. Intercellular migration of chromatin appears most frequently at the stage of synizesis. Cytomixis has been studied in relation to variation and evolution. Chromosome aberration has been considered to be closely associated with chromatin extrusion. By vital microscopic observations of the live tissues of garlic (Allium sativum L.) bud and wheat (Triticum aestivum L.) ovule combined with cinemicroscopy and video recording it has been uncovered that, not only the nuclear material but also the cytoplasm could traverse the intercellular channels by vigorous contraction and expansion, and they may simultaneously extrude out of a cell but often asynchronously migrate from one cell to another. The involvement of cytoplasmic constituents in intercellular migration was also detected in pollen mother cells with electron microscopy. Regarding the mechanism of intercellular movement a series of experiments provide convincing evidence showing that this kind of movement is an active metabolic process closely coupled with energy metabolism, and the motive power for driving the extrusion may be supplied by the contractile proteins in protoplasm.展开更多
文摘目的探讨脑桥旁正中梗死急性期运动功能缺损进展(progressive motor deficits,PMDs)的危险因素。方法2017年12月至2020年12月,在本院连续入组发病24 h内的脑桥梗死患者。入院后1周内每日行美国国立卫生院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分,若其中运动项目评分较入院增加≥1分则纳入进展组,反之为非进展组。比较两组患者人口统计学、临床资料和影像学特征,采用单因素分析及多因素logistic回归分析。结果共纳入脑桥旁正中梗死患者109例,31例出现PMDs。单因素分析提示:进展组与非进展组在入院时吞咽障碍[14(45.1%)vs.14(17.9%)]、最大梗死灶位置处于脑桥下部[19(61.3%)vs.25(32.1%)]、病灶累及腹侧[19(61.3%)vs.22(28.2%)]及病因分型[小动脉疾病11(35.5%)vs.52(66.7%)、基底动脉分支动脉疾病16(51.6%)vs.19(24.4%)]方面,差异具有统计学意义(P<0.05)。多因素logistic回归分析提示病灶累及脑桥腹侧(OR=3.453,95%CI:1.402~8.505,P=0.007)、最大梗死灶位置处于脑桥下部(OR=2.795,95%CI:1.134~6.887,P=0.026)是发生PMDs的危险因素。结论病灶累及脑桥腹侧、最大梗死灶位置处于脑桥下部可预测脑桥旁正中梗死患者运动缺损进展。
文摘Since nuclear extrusion was rediscovered in young Allium scale by S.H.WU in the years of 1950's systematic investigations on this phenomenon were carried out with various kinds of microscopic techniques and plant materials to collect more effective evidence to clarify the debate about whether the nuclear extrusion is an artifact or normal event. In the cooperative research of S. H. WU and C. H. LOU the normality of the occurrence of nuclear extrusion either in growing part of plant or in senescent tissue has been confirmed. This event is intimately associated with the physiological state of the tissues/cells and may play an important role in redistribution and reutilization of cell contents. Based on the results obtained a hypothesis of intercellular movement of protoplasm as a means of translocation of organic material in plants was suggested. Chromatin extrusion was also discovered in the pollen mother cells (cytomixis) of certain angiosperms by G. C. ZHENG and his team. Intercellular migration of chromatin appears most frequently at the stage of synizesis. Cytomixis has been studied in relation to variation and evolution. Chromosome aberration has been considered to be closely associated with chromatin extrusion. By vital microscopic observations of the live tissues of garlic (Allium sativum L.) bud and wheat (Triticum aestivum L.) ovule combined with cinemicroscopy and video recording it has been uncovered that, not only the nuclear material but also the cytoplasm could traverse the intercellular channels by vigorous contraction and expansion, and they may simultaneously extrude out of a cell but often asynchronously migrate from one cell to another. The involvement of cytoplasmic constituents in intercellular migration was also detected in pollen mother cells with electron microscopy. Regarding the mechanism of intercellular movement a series of experiments provide convincing evidence showing that this kind of movement is an active metabolic process closely coupled with energy metabolism, and the motive power for driving the extrusion may be supplied by the contractile proteins in protoplasm.
