The COP9 signalosome and the regulatory lid of the 26S proteasome are both eight-subunit protein complexes which are present in most eukaryotes. There is a one-to-one relationship between the corresponding subunits of...The COP9 signalosome and the regulatory lid of the 26S proteasome are both eight-subunit protein complexes which are present in most eukaryotes. There is a one-to-one relationship between the corresponding subunits of the two protein complexes in terms of their size and amino acid sequences. Eight groups of subunits from the COP9 signalosome and the proteasome lid complex of different organisms are collected from all the databases at the NCBI website. The corresponding subunits of COP9 signalosome and proteasome lid complex share at least 12% amino acid identity and some conserved regions, and the conserved sites spread evenly over the entire length of the subunits, suggesting that the two complexes have a common evolutionary ancestor. Phylogenetic analyses based on the amino acid sequences of the corresponding subunits of two protein complexes indicate that every tree consists of two clades. The subunits from one of the two protein complexes of different organisms are grouped into one of the two clades respectively. The sequences of single-cell organisms are always the basal groups to that of multi-cell animal and plant species. These results imply that the duplication/divergence events of COP9 signalosome and regulatory lid of the proteasome genes have occurred before the divergence of single-cell and multi-cell eukaryotes, and the genes of the two complexes are independently evolved. The analyses of dN/dS correlation show significant Pearson's correlations between 21 and 15 pairs of subunit-encoding sequences within the COP9 signalosome and the proteasome lid complex respectively, suggesting that those subunits pairs might have related functions and interacted with one another, and resulted in co-evolution.展开更多
A modified evolution model of self-organized criticality on generalized Barabasi-Albert (GBA).scale-free networks is investigated. In our model, we find that spatial and temporal correlations exhibit critical behavi...A modified evolution model of self-organized criticality on generalized Barabasi-Albert (GBA).scale-free networks is investigated. In our model, we find that spatial and temporal correlations exhibit critical behaviors. More importantly, these critical behaviors change with the parameter b, which weights the distance in comparison with the degree in the GBA network evolution.展开更多
This paper uses data for the period 1950-2050 compiled by the United Nations Population Division together with methods including spatial autocorrelation analysis, hie- rarchical cluster analysis and the standard devia...This paper uses data for the period 1950-2050 compiled by the United Nations Population Division together with methods including spatial autocorrelation analysis, hie- rarchical cluster analysis and the standard deviational ellipse, to analyze the spatio-temporal evolution of population and urbanization in the 75 countries located along the routes of the Silk Road Economic Belt and the 21st-century Maritime Silk Road, to identify future popula- tion growth and urbanization hotspots. The results reveal the following: First, in 2015, the majority of Belt and Road countries in Europe, South Asia and Southeast Asia had high population densities, whereas most countries in Central Asia, North Africa and West Asia, as well as Russia and Mongolia, had low population densities; the majority of countries in South Asia, Southeast Asia, Central Asia, West Asia and North Africa had rapid population growth, whereas many countries in Europe had negative population growth; and five Belt and Road countries are in the initial stage of urbanization, 44 countries are in the acceleration stage of urbanization, and 26 are in the terminal stage of urbanization. Second, in the century from 1950 to 2050, the mean center of the study area's population is consistently located in the border region between India and China. Prior to 2000, the trajectory of the mean center was from northwest to southeast, but from 2000 it is on a southward trajectory, as the population of the study area becomes more concentrated. Future population growth hotspots are predicted to be in South Asia, West Asia and Southeast Asia, and hotspot countries for the period 2015-2030 include India, China, Pakistan and Indonesia, though China will move into nega- tive population growth after 2030. Third, the overall urban population of Belt and Road coun- tries increased from 22% in 1950 to 49% in 2015, and it is expected to gradually catch up with the world average, reaching 64% in 2050. The different levels of urbanization in different countries display significant spatial dependency, and in the hundred-year period under con-sideration, this dependency increases before eventually weakening. Fourth, between 2015 and 2030, urban population hotspots will include Thailand, China, Laos and Albania, while Kuwait, Cyprus, Qatar and Estonia will be urban "coldspots." Fifth, there were 293 cities with populations over 1 million located along the Belt and Road in 2015, but that number Js ex- pected to increase to 377 by 2030. Of those, 43 will be in China, with many of the others located in India, Indonesia and the eastern Mediterranean.展开更多
After a composite service is deployed, user privacy requirements and trust levels of component services are subject to variation. When the changes occur, it is critical to preserve privacy information flow security. W...After a composite service is deployed, user privacy requirements and trust levels of component services are subject to variation. When the changes occur, it is critical to preserve privacy information flow security. We propose an approach to preserve privacy information flow security in composite service evolution. First, a privacy data item dependency analysis method based on a Petri net model is presented. Then the set of privacy data items collected by each component service is derived through a privacy data item dependency graph, and the security scope of each component service is calculated. Finally, the evolution operations that preserve privacy information flow security are defined. By applying these evolution operations, the re-verification process is avoided and the evolution efficiency is improved. To illustrate the effectiveness of our approach, a case study is presented. The experimental results indicate that our approach has high evolution efficiency and can greatly reduce the cost of evolution compared with re-verifying the entire composite service.展开更多
文摘The COP9 signalosome and the regulatory lid of the 26S proteasome are both eight-subunit protein complexes which are present in most eukaryotes. There is a one-to-one relationship between the corresponding subunits of the two protein complexes in terms of their size and amino acid sequences. Eight groups of subunits from the COP9 signalosome and the proteasome lid complex of different organisms are collected from all the databases at the NCBI website. The corresponding subunits of COP9 signalosome and proteasome lid complex share at least 12% amino acid identity and some conserved regions, and the conserved sites spread evenly over the entire length of the subunits, suggesting that the two complexes have a common evolutionary ancestor. Phylogenetic analyses based on the amino acid sequences of the corresponding subunits of two protein complexes indicate that every tree consists of two clades. The subunits from one of the two protein complexes of different organisms are grouped into one of the two clades respectively. The sequences of single-cell organisms are always the basal groups to that of multi-cell animal and plant species. These results imply that the duplication/divergence events of COP9 signalosome and regulatory lid of the proteasome genes have occurred before the divergence of single-cell and multi-cell eukaryotes, and the genes of the two complexes are independently evolved. The analyses of dN/dS correlation show significant Pearson's correlations between 21 and 15 pairs of subunit-encoding sequences within the COP9 signalosome and the proteasome lid complex respectively, suggesting that those subunits pairs might have related functions and interacted with one another, and resulted in co-evolution.
基金The project supported by National Natural Science Foundation of China under Grant No. 90203008 and the Doctoral Foundation of Ministry of Education of China
文摘A modified evolution model of self-organized criticality on generalized Barabasi-Albert (GBA).scale-free networks is investigated. In our model, we find that spatial and temporal correlations exhibit critical behaviors. More importantly, these critical behaviors change with the parameter b, which weights the distance in comparison with the degree in the GBA network evolution.
基金The Strategic Priority Research Program of the CAS,Pan-Third Pole Environment Study for a Green Silk Road(Pan-TPE),No.XDA20040400Key Deployment Project of the CAS,No.ZDRW-ZS-2016-6-2
文摘This paper uses data for the period 1950-2050 compiled by the United Nations Population Division together with methods including spatial autocorrelation analysis, hie- rarchical cluster analysis and the standard deviational ellipse, to analyze the spatio-temporal evolution of population and urbanization in the 75 countries located along the routes of the Silk Road Economic Belt and the 21st-century Maritime Silk Road, to identify future popula- tion growth and urbanization hotspots. The results reveal the following: First, in 2015, the majority of Belt and Road countries in Europe, South Asia and Southeast Asia had high population densities, whereas most countries in Central Asia, North Africa and West Asia, as well as Russia and Mongolia, had low population densities; the majority of countries in South Asia, Southeast Asia, Central Asia, West Asia and North Africa had rapid population growth, whereas many countries in Europe had negative population growth; and five Belt and Road countries are in the initial stage of urbanization, 44 countries are in the acceleration stage of urbanization, and 26 are in the terminal stage of urbanization. Second, in the century from 1950 to 2050, the mean center of the study area's population is consistently located in the border region between India and China. Prior to 2000, the trajectory of the mean center was from northwest to southeast, but from 2000 it is on a southward trajectory, as the population of the study area becomes more concentrated. Future population growth hotspots are predicted to be in South Asia, West Asia and Southeast Asia, and hotspot countries for the period 2015-2030 include India, China, Pakistan and Indonesia, though China will move into nega- tive population growth after 2030. Third, the overall urban population of Belt and Road coun- tries increased from 22% in 1950 to 49% in 2015, and it is expected to gradually catch up with the world average, reaching 64% in 2050. The different levels of urbanization in different countries display significant spatial dependency, and in the hundred-year period under con-sideration, this dependency increases before eventually weakening. Fourth, between 2015 and 2030, urban population hotspots will include Thailand, China, Laos and Albania, while Kuwait, Cyprus, Qatar and Estonia will be urban "coldspots." Fifth, there were 293 cities with populations over 1 million located along the Belt and Road in 2015, but that number Js ex- pected to increase to 377 by 2030. Of those, 43 will be in China, with many of the others located in India, Indonesia and the eastern Mediterranean.
基金Project supported by the National Natural Science Foundation of China(Nos.61562087 and 61772270)the National High-Tech R&D Program(863)of China(No.2015AA015303)+2 种基金the Natural Science Foundation of Jiangsu Province,China(No.BK20130735)the Universities Natural Science Foundation of Jiangsu Province,China(No.13KJB520011)the Science Foundation of Nanjing Institute of Technology,China(No.YKJ201420)
文摘After a composite service is deployed, user privacy requirements and trust levels of component services are subject to variation. When the changes occur, it is critical to preserve privacy information flow security. We propose an approach to preserve privacy information flow security in composite service evolution. First, a privacy data item dependency analysis method based on a Petri net model is presented. Then the set of privacy data items collected by each component service is derived through a privacy data item dependency graph, and the security scope of each component service is calculated. Finally, the evolution operations that preserve privacy information flow security are defined. By applying these evolution operations, the re-verification process is avoided and the evolution efficiency is improved. To illustrate the effectiveness of our approach, a case study is presented. The experimental results indicate that our approach has high evolution efficiency and can greatly reduce the cost of evolution compared with re-verifying the entire composite service.