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HIV-1CRF_07BC重组型逆转录酶区耐药进化通路分析 被引量:4
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作者 李臻鹏 黄洋 +4 位作者 欧阳雅博 邢辉 廖玲洁 邵一鸣 马丽英 《中华预防医学杂志》 CAS CSCD 北大核心 2014年第4期301-306,共6页
目的 探讨HIV-1的CRF_07BC重组型在药物压力下的进化通路,并与B亚型进行比较.方法 病毒样本来自2007-2011年新疆维吾尔自治区和四川省参加艾滋病多中心队列研究的共862例AIDS患者.根据未治疗的588例和治疗的274例AIDS患者病毒样本的逆... 目的 探讨HIV-1的CRF_07BC重组型在药物压力下的进化通路,并与B亚型进行比较.方法 病毒样本来自2007-2011年新疆维吾尔自治区和四川省参加艾滋病多中心队列研究的共862例AIDS患者.根据未治疗的588例和治疗的274例AIDS患者病毒样本的逆转录酶区序列,采用选择压力的方法识别耐药相关位点,使用贝叶斯网络法构建CRF 07BC重组型在抗病毒治疗下的耐药进化通路,同时利用国际HIV耐药数据库中的数据构建B亚型在相同治疗方案下耐药进化通路,并与CRF_07BC重组型进行比较.结果 预测的CRF_07BC重组型主要耐药位点为K103N、Q197K、V179D和Y188L.预测的B亚型主要耐药位点为M184V、K103N、Y181C、T69N、G190A、K238T、Y188H和P225H.两者重叠较小,但经典的TAM1(41L、210W和215Y)和TAM2(67N、70R和219E/Q)通路均存在于两个病毒类型中.不同于B亚型的是,预测的CRF_07BC重组型的主要耐药位点中不包含TAM相关突变,并且在核苷类药物相关突变与非核苷类药物相关突变之间存在强的依赖关系.结论 HIV-1 CRF_07BC重组型形成了以K103N、Q197K、V179D和Y188L为主要耐药位点的独特耐药进化通路,并与B亚型的耐药进化通路有较大差异. 展开更多
关键词 生物进化 耐药进化通路 耐药位点
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小细胞肺癌的的分子发病机制 被引量:2
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作者 李红洁 李晓平 +1 位作者 Sandra P.DA'NGELO M.Catherine PIETANZA 《中国肺癌杂志》 CAS 2010年第11期1086-1097,共12页
在美国,SCLC(small cell lung cancer,SCLC)占所有确诊肺癌病例的13%。尽管其对放、化疗均较敏感,但SCLC复发迅速,患者的五年生存率仅为5%。这种极差的预后可能要归咎于治疗方式的进展缓慢,因为在过去三十年中,针对SCLC的医... 在美国,SCLC(small cell lung cancer,SCLC)占所有确诊肺癌病例的13%。尽管其对放、化疗均较敏感,但SCLC复发迅速,患者的五年生存率仅为5%。这种极差的预后可能要归咎于治疗方式的进展缓慢,因为在过去三十年中,针对SCLC的医疗及护理方案并无明显变化。 展开更多
关键词 SCLC 染色体 抑癌基因 癌基因 酪氨酸受体激酶 进化通路
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Multi-objective evolutionary approach for UAV cruise route planning to collect traffic information 被引量:9
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作者 刘晓锋 彭仲仁 +1 位作者 常云涛 张立业 《Journal of Central South University》 SCIE EI CAS 2012年第12期3614-3621,共8页
Unmanned aerial vehicle(UAV)was introduced as a novel traffic device to collect road traffic information and its cruise route planning problem was considered.Firstly,a multi-objective optimization model was proposed a... Unmanned aerial vehicle(UAV)was introduced as a novel traffic device to collect road traffic information and its cruise route planning problem was considered.Firstly,a multi-objective optimization model was proposed aiming at minimizing the total cruise distance and the number of UAVs used,which used UAV maximum cruise distance,the number of UAVs available and time window of each monitored target as constraints.Then,a novel multi-objective evolutionary algorithm was proposed.Next,a case study with three time window scenarios was implemented.The results show that both the total cruise distance and the number of UAVs used continue to increase with the time window constraint becoming narrower.Compared with the initial optimal solutions,the optimal total cruise distance and the number of UAVs used fall by an average of 30.93% and 31.74%,respectively.Finally,some concerns using UAV to collect road traffic information were discussed. 展开更多
关键词 traffic information collection unmanned aerial vehicle cruise route planning multi-objective optimization
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A GIS-Based Evaluation of Environmental Sensitivity for an Urban Expressway in Shenzhen, China 被引量:2
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作者 Qian Li Fengqing Guo Yuntao Guan 《Engineering》 2018年第2期66-70,共5页
Urban eco-environmental degradation is becoming inevitable due to the extensive urbanization, popula- tion growth, and socioeconomic development in China. One of the traffic arteries in Shenzhen is an urban expressway... Urban eco-environmental degradation is becoming inevitable due to the extensive urbanization, popula- tion growth, and socioeconomic development in China. One of the traffic arteries in Shenzhen is an urban expressway that is under construction and that runs across environmentally sensitive areas (ESAs). The environmental pollution from urban expressways is critical, due to the characteristics of expressways such as high runoff coefficients, considerable contaminant accumulation, and complex pollutant ingredi- ents. ESAs are vulnerable to anthropogenic disturbances and hence should be given special attention. In order to evaluate the environmental sensitivity along this urban expressway and minimize the influences of the ongoing road construction and future operation on the surrounding ecosystem, the environmental sensitivity of the relevant area was evaluated based on the application of a geographic information sys- tem (GIS). A final ESA map was classified into four environmental sensitivity levels; this classification indicates that a large proportion of the expressway passes through areas of high sensitivity, representing 11.93 km or 52.3% of the total expressway, and more than 90% of the total expressway passes through ESAs. This study provides beneficial information for optimal layout schemes of initial rainfall runofftreatment facilities developed from low-impact development (LID) techniques in order to minimize the impact of polluted road runoff on the surrounding ecological environment. 展开更多
关键词 Environmentally sensitive areas Urban expressway Geographic information system Low-impact development
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Optimization of air quantity regulation in mine ventilation networks using the improved differential evolution algorithm and critical path method 被引量:17
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作者 Chen Kaiyan Si Junhong +3 位作者 Zhou Fubao Zhang Renwei Shao He Zhao Hongmei 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2015年第1期79-84,共6页
In mine ventilation networks, the reasonable airflow distribution is very important for the production safety and economy. Three basic problems of the natural, full-controlled and semi-controlled splitting were review... In mine ventilation networks, the reasonable airflow distribution is very important for the production safety and economy. Three basic problems of the natural, full-controlled and semi-controlled splitting were reviewed in the paper. Aiming at the high difficulty semi-controlled splitting problem, the general nonlinear multi-objectives optimization mathematical model with constraints was established based on the theory of mine ventilation networks. A new algorithm, which combined the improved differential evaluation and the critical path method (CPM) based on the multivariable separate solution strategy, was put forward to search for the global optimal solution more efficiently. In each step of evolution, the feasible solutions of air quantity distribution are firstly produced by the improved differential evolu- tion algorithm, and then the optimal solutions of regulator pressure drop are obtained by the CPM. Through finite steps iterations, the optimal solution can be given. In this new algorithm, the population of feasible solutions were sorted and grouped for enhancing the global search ability and the individuals in general group were randomly initialized for keeping diversity. Meanwhile, the individual neighbor- hood in the fine group which may be closely to the optimal solutions were searched locally and slightly for achieving a balance between global searching and local searching, thus improving the convergence rate. The computer program was developed based on this method. Finally, the two ventilation networks with single-fan and multi-fans were solved. The results show that this algorithm has advantages of high effectiveness, fast convergence, good robustness and flexibility. This computer program could be used to solve lar^e-scale ~eneralized ventilation networks o^timization problem in the future. 展开更多
关键词 Mine ventilation networkDifferential evolution algorithmCritical path methodPopulation group and neighborhood searchMultivariable separate solution
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