Background-The pattern of saphenous vein graft(SVG) calcification before percutaneous intervention has not been studied. Methods and Results-We used diagnostic and preintervention intravascular ultrasound(IVUS) to det...Background-The pattern of saphenous vein graft(SVG) calcification before percutaneous intervention has not been studied. Methods and Results-We used diagnostic and preintervention intravascular ultrasound(IVUS) to determine the incidence and magnitude of SVG calcification in 334 SVG lesions in 274 consecutive patients. Calcium was found in 133 SVGs(40%). Calcium was uniformly distributed among 48 lesion sites(14%), 43 proximal references(13%), and 42 distal references(13%). Calcium was superficial in 20(40%) and deep in 28(60%). Over the entire length of the SVGs, the maximum arc and length of calcium(in calcium-containing SVGs) averaged 174±107°and 6.8±4.8mm, respectively. In calcium-containing SVGs, lesion site arc and length of calcium measured 1.51±107°and 4.1±3.7mm, similar to the proximal and distal references(175±121°and 4.0±2.3 mm and 177±121°and 4.1±2.5mm, respectively). Graft age(7.5±4.7 versus 10.5±4.7 years, P< 0.0001), insulin-treated diabetes mellitus(40%versus 60%, P=0.02), and tobacco use(44%versus 55%, P=0.06) were clinical independent predictors of SVG calcification. Conclusions-Sixty-five percent of calcium-containing SVGs had reference calcium in the absence of lesion calcium. Calcium was located primarily in SVG wall and not at the plaque. These data suggest that SVG calcium is not just part of lesion formation and maturation. SVG calcium occurred more commonly in older grafts, in insulin-treated diabetic patients, and in smokers.展开更多
AIM: To investigate relationships between colorectal adenoma incidence, metabolic syndrome (MS) components and lifestyle factors. METHODS: We conducted a retrospective cohort study using data from individuals who had ...AIM: To investigate relationships between colorectal adenoma incidence, metabolic syndrome (MS) components and lifestyle factors. METHODS: We conducted a retrospective cohort study using data from individuals who had multiple sigmoidoscopies for colon cancer at the Health Promotion Center of Ulsan University Hospital in Korea from 1998 to 2007. RESULTS: By multivariate analysis, the incidence of distal colon adenoma was increased by more than 1.76 times in individuals with at least one component of MS compared to those without a component of MS. After adjustment for age, gender, smoking, drinking, and physical exercise, only high body mass index (BMI) was significantly associated with the incidence of distal colon adenoma (Hazard ratio 1.66, 95% confidence interval 1.05-2.62). CONCLUSION: Our results suggest that high BMI may increase the risk of colorectal adenoma in Korean adults.展开更多
文摘Background-The pattern of saphenous vein graft(SVG) calcification before percutaneous intervention has not been studied. Methods and Results-We used diagnostic and preintervention intravascular ultrasound(IVUS) to determine the incidence and magnitude of SVG calcification in 334 SVG lesions in 274 consecutive patients. Calcium was found in 133 SVGs(40%). Calcium was uniformly distributed among 48 lesion sites(14%), 43 proximal references(13%), and 42 distal references(13%). Calcium was superficial in 20(40%) and deep in 28(60%). Over the entire length of the SVGs, the maximum arc and length of calcium(in calcium-containing SVGs) averaged 174±107°and 6.8±4.8mm, respectively. In calcium-containing SVGs, lesion site arc and length of calcium measured 1.51±107°and 4.1±3.7mm, similar to the proximal and distal references(175±121°and 4.0±2.3 mm and 177±121°and 4.1±2.5mm, respectively). Graft age(7.5±4.7 versus 10.5±4.7 years, P< 0.0001), insulin-treated diabetes mellitus(40%versus 60%, P=0.02), and tobacco use(44%versus 55%, P=0.06) were clinical independent predictors of SVG calcification. Conclusions-Sixty-five percent of calcium-containing SVGs had reference calcium in the absence of lesion calcium. Calcium was located primarily in SVG wall and not at the plaque. These data suggest that SVG calcium is not just part of lesion formation and maturation. SVG calcium occurred more commonly in older grafts, in insulin-treated diabetic patients, and in smokers.
基金Supported by The Biomedical Research Center Promotion Fund of the Ulsan University Hospital (UUH-2008-08)
文摘AIM: To investigate relationships between colorectal adenoma incidence, metabolic syndrome (MS) components and lifestyle factors. METHODS: We conducted a retrospective cohort study using data from individuals who had multiple sigmoidoscopies for colon cancer at the Health Promotion Center of Ulsan University Hospital in Korea from 1998 to 2007. RESULTS: By multivariate analysis, the incidence of distal colon adenoma was increased by more than 1.76 times in individuals with at least one component of MS compared to those without a component of MS. After adjustment for age, gender, smoking, drinking, and physical exercise, only high body mass index (BMI) was significantly associated with the incidence of distal colon adenoma (Hazard ratio 1.66, 95% confidence interval 1.05-2.62). CONCLUSION: Our results suggest that high BMI may increase the risk of colorectal adenoma in Korean adults.
