Launch barge is an effective tool for transporting ship segments from one place to another in shipyards. During shifting of segments onto a barge, the slideway on the barge＇s deck must be adjusted to maintain the sam...Launch barge is an effective tool for transporting ship segments from one place to another in shipyards. During shifting of segments onto a barge, the slideway on the barge＇s deck must be adjusted to maintain the same level as the wharf and also the barge must be kept level by adjusting the water in the ballast tanks. When to open the adjusting valves is an important factor influencing the barge＇s trim during the water-adjustment process. Because these adjustments are complex a mathematical model was formulated,after analyzing the characteristics of the process of moving the segments onto the barges deck, and considering the effects of this movement＇s speed and variations in tidal levels during the move. Then the model was solved by the penalty function method, the grid method, and improved simulated annealing, respectively. The best optimization model and its corresponding solution were then determined. Finally, it was proven that the model and the method adopted are correct and suitable, by calculating and analysing an example.展开更多
To investigate the optimal retail price and service level in a supply chain under consumer returns, a consumer returns model under the retailer＇s service provision is built. The optimal decision results and optimal p...To investigate the optimal retail price and service level in a supply chain under consumer returns, a consumer returns model under the retailer＇s service provision is built. The optimal decision results and optimal profits are obtained in the vertical integration game and the manufacturer Stackelberg game, respectively. Through comparing the optimal profits with service provision with those of no service provision, the boundary conditions that the retailer＇s service should be provided are derived. The results show that in the manufacturer Stackelberg game, the optimal profit of the retailer and the manufacturer with service is always superior to that of a no service provision. However, in the vertical integration game, the supply chain can only benefit from the service under certain conditions. Finally, through numerical examples, the impacts of the cost for providing services and the consumer return rate on the optimal decisions are analyzed.展开更多
NF-κB-inducing kinase （NIK） is required for NF-κB activation based on the processing of NF-κB p100. Here we report a novel mechanism of NIK regulation involving the chaperone 90 kDa heat shock protein （Hsp90） a...NF-κB-inducing kinase （NIK） is required for NF-κB activation based on the processing of NF-κB p100. Here we report a novel mechanism of NIK regulation involving the chaperone 90 kDa heat shock protein （Hsp90） and autophagy. Functional inhibition of lisp90 by the anti-tumor agent geldanamycin （GA） efficiently disrupts its interaction with NIK, resulting in NIK degradation and subsequent blockage of p100 processing. Surprisingly, GA-induced NIK degradation is mediated by autophagy, but largely independent of the ubiquitin-proteasome system. Hsp90 seems to be specifically involved in the folding/stabilization of NIK protein, because GA inhibition does not affect NIK mRNA transcription and translation. Furthermore, Hsp90 is not required for NIK-mediated recruitment of the α subunit of IκB3 kinase to p 100, a key step in induction of p100 processing. These findings define an alternative mechanism for Hsp90 client degradation and identify a novel function ofautophagy in NF-κB regulation. These findings also suggest a new therapeutic strategy for diseases associated with p 100 processing.展开更多
Glacier area changes in the Qangtang Plateau are analyzed during 1970-2000 using air photos,relevant photogrammetric maps and satellite images based on the multi-temporal grid method.The results indicate that the melt...Glacier area changes in the Qangtang Plateau are analyzed during 1970-2000 using air photos,relevant photogrammetric maps and satellite images based on the multi-temporal grid method.The results indicate that the melting of glaciers accelerated,only a few of glaciers in an advancing state during 1970-2000 in the whole Qangtang Plateau.However,the glaciers seemed still more stable in the study area than in most areas of western China.We estimate that glacier retreat was likely due to air temperature warming during 1970-2000 in the Qangtang Plateau.Furthermore,the functional model of glacier system is applied to study climate sensitivity of glacier area changes,which indicates that glacier lifespan mainly depends on the heating rate,secondly the precipitation,and precipitation increasing can slow down glacier retreat and make glacier lifespan prolonged.展开更多
The ilvaite-bearing skarn associations in the Galinge skarn deposit were studied to determine their physicochemical formation conditions.A thermodynamic model setting pressure of 50 MPa(Pf=Ps=50 MPa)was set up to trac...The ilvaite-bearing skarn associations in the Galinge skarn deposit were studied to determine their physicochemical formation conditions.A thermodynamic model setting pressure of 50 MPa(Pf=Ps=50 MPa)was set up to trace the skarn evolution.Petrographic evidence for replacement of garnet and magnetite by ilvaite in the early retrograde stage(Stage I)combined with thermodynamic modeling suggests that the alteration may have occurred at 400470°C under moderately high fO withΔlgfO(HM)ranges from 4 to 4.2.The model is based on a maximum 22 pressure of 50 MPa calculated from magmatic amphibole geobarometer.The continuous breakdown of ilvaite with quartz to form ferro-actinolite and magnetite occur in the late retrograde stage(Stage II).The reactions occurred at 400440°C under moderate fO(ΔlgfO(HM):4 to 4.4).In Stage III,the breakdown of ilvaite to form calcite,pyrite 22 and ferroactinolite depends on XCO which can be estimated to be in a range of 0.005 to 0.05,and the reaction would 2 occur at higher temperatures with increasing XCO.Under these conditions,the breakdown occurs at 270350°C and 2 low fO(ΔlgfO(HM):up to 5.2).The thermodynamic model for continuous evolution from Stage I to Stage III 22 completely records the conditions of the retrograde alteration,which is inconsistent with the thermobarometry imprints of fluid inclusions.Therefore,the petrography and phase relations of ilvaite are useful indicators of reaction conditions in various skarn deposit types.展开更多
We calculate one-loop R-parity-violating coupling corrections to theprocesses H~- → τv_τ and H~- → bt. We find that the corrections to the H~- → τv_τ decay modeare generally about 0.1%, and can be negligible. B...We calculate one-loop R-parity-violating coupling corrections to theprocesses H~- → τv_τ and H~- → bt. We find that the corrections to the H~- → τv_τ decay modeare generally about 0.1%, and can be negligible. But the corrections to the H~- → bt decay mode canreach a few percent for the favored parameters.展开更多
文摘Launch barge is an effective tool for transporting ship segments from one place to another in shipyards. During shifting of segments onto a barge, the slideway on the barge＇s deck must be adjusted to maintain the same level as the wharf and also the barge must be kept level by adjusting the water in the ballast tanks. When to open the adjusting valves is an important factor influencing the barge＇s trim during the water-adjustment process. Because these adjustments are complex a mathematical model was formulated,after analyzing the characteristics of the process of moving the segments onto the barges deck, and considering the effects of this movement＇s speed and variations in tidal levels during the move. Then the model was solved by the penalty function method, the grid method, and improved simulated annealing, respectively. The best optimization model and its corresponding solution were then determined. Finally, it was proven that the model and the method adopted are correct and suitable, by calculating and analysing an example.
基金The National Natural Science Foundation of China(No.71171049)the Scientific Innovation Research of College Graduates in Jiangsu Province(No.CXLX_0122)
文摘To investigate the optimal retail price and service level in a supply chain under consumer returns, a consumer returns model under the retailer＇s service provision is built. The optimal decision results and optimal profits are obtained in the vertical integration game and the manufacturer Stackelberg game, respectively. Through comparing the optimal profits with service provision with those of no service provision, the boundary conditions that the retailer＇s service should be provided are derived. The results show that in the manufacturer Stackelberg game, the optimal profit of the retailer and the manufacturer with service is always superior to that of a no service provision. However, in the vertical integration game, the supply chain can only benefit from the service under certain conditions. Finally, through numerical examples, the impacts of the cost for providing services and the consumer return rate on the optimal decisions are analyzed.
文摘NF-κB-inducing kinase （NIK） is required for NF-κB activation based on the processing of NF-κB p100. Here we report a novel mechanism of NIK regulation involving the chaperone 90 kDa heat shock protein （Hsp90） and autophagy. Functional inhibition of lisp90 by the anti-tumor agent geldanamycin （GA） efficiently disrupts its interaction with NIK, resulting in NIK degradation and subsequent blockage of p100 processing. Surprisingly, GA-induced NIK degradation is mediated by autophagy, but largely independent of the ubiquitin-proteasome system. Hsp90 seems to be specifically involved in the folding/stabilization of NIK protein, because GA inhibition does not affect NIK mRNA transcription and translation. Furthermore, Hsp90 is not required for NIK-mediated recruitment of the α subunit of IκB3 kinase to p 100, a key step in induction of p100 processing. These findings define an alternative mechanism for Hsp90 client degradation and identify a novel function ofautophagy in NF-κB regulation. These findings also suggest a new therapeutic strategy for diseases associated with p 100 processing.
基金supported by the National Natural Science Foundation of China (Nos.40871043,40801025)the Project of National Scientific Basic Special Fund on the Ministry of Science and Technology of China (No.2006FY110200)the Key Construction Disciplines of Hunan Province (No.40652001)
文摘Glacier area changes in the Qangtang Plateau are analyzed during 1970-2000 using air photos,relevant photogrammetric maps and satellite images based on the multi-temporal grid method.The results indicate that the melting of glaciers accelerated,only a few of glaciers in an advancing state during 1970-2000 in the whole Qangtang Plateau.However,the glaciers seemed still more stable in the study area than in most areas of western China.We estimate that glacier retreat was likely due to air temperature warming during 1970-2000 in the Qangtang Plateau.Furthermore,the functional model of glacier system is applied to study climate sensitivity of glacier area changes,which indicates that glacier lifespan mainly depends on the heating rate,secondly the precipitation,and precipitation increasing can slow down glacier retreat and make glacier lifespan prolonged.
基金Projects(41172076,41802080)supported by the National Natural Science Foundation of ChinaProject(1212011085528)supported by Geological Survey Program from the China Geological Survey+3 种基金Project(2019CX035)supported by Innovation-driven Plan of Central South University,ChinaProject(201411025)supported by the Scientific Research Fund from Ministry of Land and Re-sources,ChinaProject(201309)supported by the Program of High-level Geological Talents,ChinaProject(201112)supported by the Youth Geological Talents of the China Geological Survey
文摘The ilvaite-bearing skarn associations in the Galinge skarn deposit were studied to determine their physicochemical formation conditions.A thermodynamic model setting pressure of 50 MPa(Pf=Ps=50 MPa)was set up to trace the skarn evolution.Petrographic evidence for replacement of garnet and magnetite by ilvaite in the early retrograde stage(Stage I)combined with thermodynamic modeling suggests that the alteration may have occurred at 400470°C under moderately high fO withΔlgfO(HM)ranges from 4 to 4.2.The model is based on a maximum 22 pressure of 50 MPa calculated from magmatic amphibole geobarometer.The continuous breakdown of ilvaite with quartz to form ferro-actinolite and magnetite occur in the late retrograde stage(Stage II).The reactions occurred at 400440°C under moderate fO(ΔlgfO(HM):4 to 4.4).In Stage III,the breakdown of ilvaite to form calcite,pyrite 22 and ferroactinolite depends on XCO which can be estimated to be in a range of 0.005 to 0.05,and the reaction would 2 occur at higher temperatures with increasing XCO.Under these conditions,the breakdown occurs at 270350°C and 2 low fO(ΔlgfO(HM):up to 5.2).The thermodynamic model for continuous evolution from Stage I to Stage III 22 completely records the conditions of the retrograde alteration,which is inconsistent with the thermobarometry imprints of fluid inclusions.Therefore,the petrography and phase relations of ilvaite are useful indicators of reaction conditions in various skarn deposit types.
文摘We calculate one-loop R-parity-violating coupling corrections to theprocesses H~- → τv_τ and H~- → bt. We find that the corrections to the H~- → τv_τ decay modeare generally about 0.1%, and can be negligible. But the corrections to the H~- → bt decay mode canreach a few percent for the favored parameters.
