Synthesis of superabsorbent of starch-graft-poly(patassium acrylate-co-acrylamide) has been studied by inverse suspension polymerization.In this paper,the effects of reaction conditions,such as ,monomeric concentratio...Synthesis of superabsorbent of starch-graft-poly(patassium acrylate-co-acrylamide) has been studied by inverse suspension polymerization.In this paper,the effects of reaction conditions,such as ,monomeric concentration,the amount of cross-linking agent,ratio of water to oil,reaction temperature and the best condition being able to obtain the spherical resin were investigated. Experiments show that the water-absorbing resin is strong and capable of resisting pressure of retain water.It keeps the shape of particles after absorbing water.After mixing with soil,it does not become sticky,and the coos structure can better retain air.It just fit agriculture and forest.In addition,thermogravimetric analysis revealed the superior thermal stability of the grafted product,and its large size particles also reduces risk of air pollution.展开更多
OBJECTIVE:To observe the effect of tetrahydroxy stilbene glucoside(TSG) on the behavior of APP695V717 I transgenic mouse models and the expression of autophagy-associated proteins Beclin-1and LC3-Ⅱ.METHODS:Forty 3-mo...OBJECTIVE:To observe the effect of tetrahydroxy stilbene glucoside(TSG) on the behavior of APP695V717 I transgenic mouse models and the expression of autophagy-associated proteins Beclin-1and LC3-Ⅱ.METHODS:Forty 3-month-old APP695V717 I transgenic mice were randomized equally into either a TSG group(n = 20) or a model group(n = 20).A normal control group consisted of C57BL/6J mice of the same age and background(n = 20).The TSG group received TSG intragastric administration for1 month.Behavior was measured using the Morris water maze and the Y-maze tests.Changes in protein expression and mRNA of autophagy-associated Beclin-1 and LC3-Ⅱ in mice hippocampus were detected by western blot and Reverse Transcription-Polymerase Chain Reaction(RT-PCR) analyses.RESULTS:The number of electric-stimulus escapes significantly increased and the Morris water maze test showed prolonged escape latency,greater swimming distance,less time taken to cross the exact former platform location in the model group,and increased mRNA and protein expressions of Beclin-1 and LC3-Ⅱ compared with the control group(P < 0.05).The TSG group showed a decrease in the number of electric-stimulus escapes,shorter escape latency and swimming distance,greater time taken to cross the exact former platform location,and decreased mRNA and protein expressions of Beclin-1 and LC3-Ⅱ compared with the model group(P< 0.05).CONCLUSION:These results indicate that tetrahydroxy stilbene glucoside can decrease expressions of Beclin-1 and LC3-Ⅱ in the autophagy pathway.It can attenuate injury to endoplasmic reticulum functions caused by Ab neurotoxicity,improving learning,memorizing,and spatial orientation behavior in mice.展开更多
文摘Synthesis of superabsorbent of starch-graft-poly(patassium acrylate-co-acrylamide) has been studied by inverse suspension polymerization.In this paper,the effects of reaction conditions,such as ,monomeric concentration,the amount of cross-linking agent,ratio of water to oil,reaction temperature and the best condition being able to obtain the spherical resin were investigated. Experiments show that the water-absorbing resin is strong and capable of resisting pressure of retain water.It keeps the shape of particles after absorbing water.After mixing with soil,it does not become sticky,and the coos structure can better retain air.It just fit agriculture and forest.In addition,thermogravimetric analysis revealed the superior thermal stability of the grafted product,and its large size particles also reduces risk of air pollution.
基金the National Natural Science Foundation of China(Effect of Tetrahydroxy Stilbene Glycoside on Endoplasmic Reticulum Stress Induced byβ-amyloid in Alzheimer's Disease,No.81303097 and the effect of Curcumin on Alzheimer's Disease based on PPARγ-HSP70 Pathway,No.81373794)
文摘OBJECTIVE:To observe the effect of tetrahydroxy stilbene glucoside(TSG) on the behavior of APP695V717 I transgenic mouse models and the expression of autophagy-associated proteins Beclin-1and LC3-Ⅱ.METHODS:Forty 3-month-old APP695V717 I transgenic mice were randomized equally into either a TSG group(n = 20) or a model group(n = 20).A normal control group consisted of C57BL/6J mice of the same age and background(n = 20).The TSG group received TSG intragastric administration for1 month.Behavior was measured using the Morris water maze and the Y-maze tests.Changes in protein expression and mRNA of autophagy-associated Beclin-1 and LC3-Ⅱ in mice hippocampus were detected by western blot and Reverse Transcription-Polymerase Chain Reaction(RT-PCR) analyses.RESULTS:The number of electric-stimulus escapes significantly increased and the Morris water maze test showed prolonged escape latency,greater swimming distance,less time taken to cross the exact former platform location in the model group,and increased mRNA and protein expressions of Beclin-1 and LC3-Ⅱ compared with the control group(P < 0.05).The TSG group showed a decrease in the number of electric-stimulus escapes,shorter escape latency and swimming distance,greater time taken to cross the exact former platform location,and decreased mRNA and protein expressions of Beclin-1 and LC3-Ⅱ compared with the model group(P< 0.05).CONCLUSION:These results indicate that tetrahydroxy stilbene glucoside can decrease expressions of Beclin-1 and LC3-Ⅱ in the autophagy pathway.It can attenuate injury to endoplasmic reticulum functions caused by Ab neurotoxicity,improving learning,memorizing,and spatial orientation behavior in mice.
