A fully integrated CMOS bio-chip is designed in a SMIC 0.18μm CMOS mixed signal process and successfully integrated with a novel bio-nano-system. The proposed circuit integrates an array of 4 × 4 （16 pixels） o...A fully integrated CMOS bio-chip is designed in a SMIC 0.18μm CMOS mixed signal process and successfully integrated with a novel bio-nano-system. The proposed circuit integrates an array of 4 × 4 （16 pixels） of 19μm × 19μm electrodes,a counter electrode, a current mode preamplifier circuit （CMPA） ,a digital decoding circuit,and control logics on a single chip, It provides a - 1.6- 1.6V range of assembly voltage,Sbit potential resolution, and a current gain of 39.8dB with supply voltage of 1.8V. The offset and noise are smaller than 5.9nA and 25.3pArms,respectively. Experimental resuits from on-chip selective assembly of 30nm poly （ethylene glycol） （PEG） coated magnetic nano-particles （MNPs） targeted at biosensor applications are included and discussed to verify the feasibility of the proposed circuits.展开更多
The design of selective and efficient covalent organic frameworks(COFs)based electrocatalysts with tunable morphology for efficient CO_(2) reduction reaction(CO_(2)RR)to CH_(4) is highly desirable.Here,two kinds of an...The design of selective and efficient covalent organic frameworks(COFs)based electrocatalysts with tunable morphology for efficient CO_(2) reduction reaction(CO_(2)RR)to CH_(4) is highly desirable.Here,two kinds of anthraquinone-based COFs(i.e.,AAn-COF and OH-AAn-COF)with tunable 1D superstructures(e.g.,nanofibers(NF)and hollow tubes(HT))have been produced via Schiff-base condensation reaction.Interestingly,a rarely reported nanosheet-based self-template mechanism and a nanosheet-crimping mechanism have been demonstrated for the production of COF-based nanofibers and hollow tubes,respectively.Besides,the obtained COF-based superstructures can be post-modified with transition metals for efficient CO_(2)RR.Specifically,AAn-COF-Cu(NF)and OH-AAn-COF-Cu(HT)exhibit superior faradaic-efficiency with CH_(4)(FECH_(4))of 77%(-128.1 mA cm^(-2),-0.9 V)and 61%(-99.5 mA cm^(-2),-1.0 V)in a flow-cell,respectively.Noteworthy,the achieved FECH_(4) of AAn-COF-Cu(NF)(77%)is the highest one among reported crystalline COFs.This work provides a general methodology in exploring morphology-controlled COFs for electrocatalytic CO_(2)RR.展开更多
文摘A fully integrated CMOS bio-chip is designed in a SMIC 0.18μm CMOS mixed signal process and successfully integrated with a novel bio-nano-system. The proposed circuit integrates an array of 4 × 4 （16 pixels） of 19μm × 19μm electrodes,a counter electrode, a current mode preamplifier circuit （CMPA） ,a digital decoding circuit,and control logics on a single chip, It provides a - 1.6- 1.6V range of assembly voltage,Sbit potential resolution, and a current gain of 39.8dB with supply voltage of 1.8V. The offset and noise are smaller than 5.9nA and 25.3pArms,respectively. Experimental resuits from on-chip selective assembly of 30nm poly （ethylene glycol） （PEG） coated magnetic nano-particles （MNPs） targeted at biosensor applications are included and discussed to verify the feasibility of the proposed circuits.
基金supported by the National Natural Science Foundation of China(21871141,21871142,21901122,22071109 and 92061101)the Natural Science Research of Jiangsu Higher Education Institutions of China(19KJB150011)+3 种基金China Postdoctoral Science Foundation(2018M630572 and 2019M651873)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX201171)Priority Academic Program Development of Jiangsu Higher Education Institutionsthe Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials.
文摘The design of selective and efficient covalent organic frameworks(COFs)based electrocatalysts with tunable morphology for efficient CO_(2) reduction reaction(CO_(2)RR)to CH_(4) is highly desirable.Here,two kinds of anthraquinone-based COFs(i.e.,AAn-COF and OH-AAn-COF)with tunable 1D superstructures(e.g.,nanofibers(NF)and hollow tubes(HT))have been produced via Schiff-base condensation reaction.Interestingly,a rarely reported nanosheet-based self-template mechanism and a nanosheet-crimping mechanism have been demonstrated for the production of COF-based nanofibers and hollow tubes,respectively.Besides,the obtained COF-based superstructures can be post-modified with transition metals for efficient CO_(2)RR.Specifically,AAn-COF-Cu(NF)and OH-AAn-COF-Cu(HT)exhibit superior faradaic-efficiency with CH_(4)(FECH_(4))of 77%(-128.1 mA cm^(-2),-0.9 V)and 61%(-99.5 mA cm^(-2),-1.0 V)in a flow-cell,respectively.Noteworthy,the achieved FECH_(4) of AAn-COF-Cu(NF)(77%)is the highest one among reported crystalline COFs.This work provides a general methodology in exploring morphology-controlled COFs for electrocatalytic CO_(2)RR.
