Hypertension is believed to be a major risk factor that causes cardiovascular disease in patients on hemodialysis （HD）. Removing of excess water during HD, accurate assessment of dry weight and anti-hypertension the...Hypertension is believed to be a major risk factor that causes cardiovascular disease in patients on hemodialysis （HD）. Removing of excess water during HD, accurate assessment of dry weight and anti-hypertension therapeutics are the most com- monly used measures to lower blood pressure in patients on HD.展开更多
Object： To observe the dynamic changes of dopamine （DA） in the striatum with the process of duplicating cerebral ischemia and reperfusion （CIR） model on rats. And observe the effect of electroacupuncture （EA） o...Object： To observe the dynamic changes of dopamine （DA） in the striatum with the process of duplicating cerebral ischemia and reperfusion （CIR） model on rats. And observe the effect of electroacupuncture （EA） on such changes. Methods： Using microdialysis sampling, high performance liquid chromatography （HPLC） detecting technology, dynamic sampling from experimental animals at multiple moments to observe the changes of dopamine in striatum with ischemia. And observe the effect of EA at Fengchi （GB 20） on such changes. Result： About the extracellular level of DA in normal group, sham-operation group and sham-operation ＋ EA group, no significant changes were observed during the measuring period. The extracellular level of DA peaked at 15-45 min after MCAO and 0-30 min （P〈0.05） after reperfusion. A rising trend was also observed following 120 min after reperfusion. After EA, the extracellular level of DA was significant lower than ischemia group following 90 min after reperfusion （P 〈0.05）. And there was no peak again. Conclusion： EA at Fenchi （GB 20） can regulate the disorder of DA. EA can improve the integrity neurological function. This may be one of the mechanisms of acupuncture treating the lesion of cerebral ischemia and reperfusion.展开更多
文摘Hypertension is believed to be a major risk factor that causes cardiovascular disease in patients on hemodialysis （HD）. Removing of excess water during HD, accurate assessment of dry weight and anti-hypertension therapeutics are the most com- monly used measures to lower blood pressure in patients on HD.
基金the Science and Technology Commission of Shanghai Municipality(014319364)the Science Foundation of Shanghai Municipal Commission of Science and Technology(05DZ19745,06DZ19732,064319053,07DZ19722,07DZ19733)+1 种基金the National Basic Research Program of China(973 Program,2005CB523306)Shanghai Leading Academic Discipline Project(B112 and T0302)
文摘Object： To observe the dynamic changes of dopamine （DA） in the striatum with the process of duplicating cerebral ischemia and reperfusion （CIR） model on rats. And observe the effect of electroacupuncture （EA） on such changes. Methods： Using microdialysis sampling, high performance liquid chromatography （HPLC） detecting technology, dynamic sampling from experimental animals at multiple moments to observe the changes of dopamine in striatum with ischemia. And observe the effect of EA at Fengchi （GB 20） on such changes. Result： About the extracellular level of DA in normal group, sham-operation group and sham-operation ＋ EA group, no significant changes were observed during the measuring period. The extracellular level of DA peaked at 15-45 min after MCAO and 0-30 min （P〈0.05） after reperfusion. A rising trend was also observed following 120 min after reperfusion. After EA, the extracellular level of DA was significant lower than ischemia group following 90 min after reperfusion （P 〈0.05）. And there was no peak again. Conclusion： EA at Fenchi （GB 20） can regulate the disorder of DA. EA can improve the integrity neurological function. This may be one of the mechanisms of acupuncture treating the lesion of cerebral ischemia and reperfusion.
