China＇s reform and opening up in the area of circulation are an important component of the establishment of a socialist mgrket economy system. Prior to reform and opening up, this area had long been characterized by ...China＇s reform and opening up in the area of circulation are an important component of the establishment of a socialist mgrket economy system. Prior to reform and opening up, this area had long been characterized by a high level of centralization, closedness and segmentation. The domestic market was isolated from the overseas market and internal trade from foreign trade, and each had its own management system and policy environment. The thirty years of reform and opening up, however, have put a new face on the institutional environment of circulation： an open and modern system of circulation has been basically established, an embryonic WTO-consistent business administration system is taking shape, and the extension Of business and trade service ixidustries has facilitated institutional innovation. The main experience of reform is the following： first, taking opening up as the leading principle and making use of opening up to promote reform; second, following an incremental path of dealing with the easier issues before the harder ones, building up while you tear down, and gradual improvement; and third, breaking through the traditional framework of commodity circulation and establishing new business systems that accommodate more service industries. The economic implication of China＇s reform experience is as follows： an export-oriented strategy must inevitably be chosen as the point of entry for reform; there is an inherent linkage between market structure and human capital in the circulation of goods and services; and expanding the circulation of non-material goods is an important basis for institutional innovation.展开更多
Powered by the mitochondrial membrane potential,Ca2+ permeates the mitochondria via a Ca2+ channel termed Ca2+ uniporter and is pumped out by a Na+/Ca2+ exchanger,both of which are located on the inner mitochondrial m...Powered by the mitochondrial membrane potential,Ca2+ permeates the mitochondria via a Ca2+ channel termed Ca2+ uniporter and is pumped out by a Na+/Ca2+ exchanger,both of which are located on the inner mitochondrial membrane.Mitochondrial Ca2+ transients are critical for metabolic activity and regulating global Ca2+ responses.On the other hand,failure to control mitochondrial Ca2+ is a hallmark of ischemic and neurodegenerative diseases.Despite their importance,identifying the uniporter and exchanger remains elusive and their inhibitors are non-specific.This review will focus on the mitochondrial exchanger,initially describing how it was molecularly identified and linked to a novel member of the Na+/Ca2+ exchanger superfamily termed NCLX.Molecular control of NCLX expression provides a selective tool to determine its physiological role in a variety of cell types.In lymphocytes,NCLX is essential for refilling the endoplasmic reticulum Ca2+ stores required for antigen-dependent signaling.Communication of NCLX with the store-operated channel in astroglia controls Ca2+ influx and thereby neuro-transmitter release and cell proliferation.The refilling of the Ca2+ stores in the sarcoplasmic reticulum,which is controlled by NCLX,determines the frequency of action potential and Ca2+ transients in cardiomyocytes.NCLX is emerging as a hub for integrating glucose-dependent Na+ and Ca2+ signaling in pancreatic β cells,and the specific molecular control of NCLX expression resolved the controversy regarding its role in neurons and β cells.Future studies on an NCLX knockdown mouse model and identification of human NCLX mutations are expected to determine the role of mitochondrial Ca2+ efflux in organ activity and whether NCLX inactivation is linked to ischemic and/or neurodegenerative syndromes.Structure-function analysis and protein analysis will identify the NCLX mode of regulation and its partners in the inner membrane of the mitochondria.展开更多
文摘China＇s reform and opening up in the area of circulation are an important component of the establishment of a socialist mgrket economy system. Prior to reform and opening up, this area had long been characterized by a high level of centralization, closedness and segmentation. The domestic market was isolated from the overseas market and internal trade from foreign trade, and each had its own management system and policy environment. The thirty years of reform and opening up, however, have put a new face on the institutional environment of circulation： an open and modern system of circulation has been basically established, an embryonic WTO-consistent business administration system is taking shape, and the extension Of business and trade service ixidustries has facilitated institutional innovation. The main experience of reform is the following： first, taking opening up as the leading principle and making use of opening up to promote reform; second, following an incremental path of dealing with the easier issues before the harder ones, building up while you tear down, and gradual improvement; and third, breaking through the traditional framework of commodity circulation and establishing new business systems that accommodate more service industries. The economic implication of China＇s reform experience is as follows： an export-oriented strategy must inevitably be chosen as the point of entry for reform; there is an inherent linkage between market structure and human capital in the circulation of goods and services; and expanding the circulation of non-material goods is an important basis for institutional innovation.
文摘Powered by the mitochondrial membrane potential,Ca2+ permeates the mitochondria via a Ca2+ channel termed Ca2+ uniporter and is pumped out by a Na+/Ca2+ exchanger,both of which are located on the inner mitochondrial membrane.Mitochondrial Ca2+ transients are critical for metabolic activity and regulating global Ca2+ responses.On the other hand,failure to control mitochondrial Ca2+ is a hallmark of ischemic and neurodegenerative diseases.Despite their importance,identifying the uniporter and exchanger remains elusive and their inhibitors are non-specific.This review will focus on the mitochondrial exchanger,initially describing how it was molecularly identified and linked to a novel member of the Na+/Ca2+ exchanger superfamily termed NCLX.Molecular control of NCLX expression provides a selective tool to determine its physiological role in a variety of cell types.In lymphocytes,NCLX is essential for refilling the endoplasmic reticulum Ca2+ stores required for antigen-dependent signaling.Communication of NCLX with the store-operated channel in astroglia controls Ca2+ influx and thereby neuro-transmitter release and cell proliferation.The refilling of the Ca2+ stores in the sarcoplasmic reticulum,which is controlled by NCLX,determines the frequency of action potential and Ca2+ transients in cardiomyocytes.NCLX is emerging as a hub for integrating glucose-dependent Na+ and Ca2+ signaling in pancreatic β cells,and the specific molecular control of NCLX expression resolved the controversy regarding its role in neurons and β cells.Future studies on an NCLX knockdown mouse model and identification of human NCLX mutations are expected to determine the role of mitochondrial Ca2+ efflux in organ activity and whether NCLX inactivation is linked to ischemic and/or neurodegenerative syndromes.Structure-function analysis and protein analysis will identify the NCLX mode of regulation and its partners in the inner membrane of the mitochondria.
