PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130

Maintenance of the Golgi apparatus （GA） structure and function depends on Golgi matrix proteins. The posttranslational modification of Golgi proteins such as phosphorylation of members of the golgin and GRASP families is important for determining Golgi architecture. Some Golgi proteins including golgin-84 are also known to be methylated, but the function of golgin methylation remains unclear. Here, we show that the protein arginine methyltransferase 5 （PRMT5） localizes to the GA and forms complexes with several components involved in GA ribbon formation and vesicle tethering. PRMT5 interacts with the golgin GM130, and depletion of PRMT5 causes defects in Golgi ribbon formation. Furthermore, PRMT5 methylates N-terminal arginines in GM130, and such arginine methylation appears critical for GA ribbon formation. Our findings reveal a molecular mechanism by which PRMT5-dependent arginine methylation of GM130 controls the maintenance of GA architecture.

ADS-B Anomaly Data Detection Model Based on Deep Learning and Difference of Gaussian Approach

Due to the influence of terrain structure,meteorological conditions and various factors,there are anomalous data in automatic dependent surveillance-broadcast(ADS-B)message.The ADS-B equipment can be used for positioning of general aviation aircraft.Aim to acquire the accurate position information of aircraft and detect anomaly data,the ADS-B anomaly data detection model based on deep learning and difference of Gaussian(DoG)approach is proposed.First,according to the characteristic of ADS-B data,the ADS-B position data are transformed into the coordinate system.And the origin of the coordinate system is set up as the take-off point.Then,based on the kinematic principle,the ADS-B anomaly data can be removed.Moreover,the details of the ADS-B position data can be got by the DoG approach.Finally,the long short-term memory(LSTM)neural network is used to optimize the recurrent neural network(RNN)with severe gradient reduction for processing ADS-B data.The position data of ADS-B are reconstructed by the sequence to sequence(seq2seq)model which is composed of LSTM neural network,and the reconstruction error is used to detect the anomalous data.Based on the real flight data of general aviation aircraft,the simulation results show that the anomaly data can be detected effectively by the proposed method of reconstructing ADS-B data with the seq2seq model,and its running time is reduced.Compared with the RNN,the accuracy of anomaly detection is increased by 2.7%.The performance of the proposed model is better than that of the traditional anomaly detection models.

The Influence of Demoiselle Aircraft on Light and General Aviation Design

In 1907, aviation pioneer Santos-Dumont had the idea of building a very light airplane. He designed and built the SD 19, the Demoiselle, an aircraft with a 6 meter wing span and a 24 HP engine of his own design. The Demoiselle was very successful in flying and, became very popular and its development continued as SD20, SD21 and SD22 （his last airplane）. The influence of the Demoiselle on design principles of light aircraft and general aviation were studied in this work, using statistical entropy, The designs number 20 and 22 may be considered dominant and influenced the design principles of light aircraft and general aviation.

Reviews and Expectations on the Maiden Voyage of a Chinese Merchant Ship in the Arctic Northeast Route

This paper introduces the preparatory work and conducts an integrated review on the maiden voyage of a Chinese commercial ship on the Arctic Northeast Route. It puts forth expectations on the exploitation and utilization of the Arctic Northeast Route in the aspects of safety, fastness, low costs, low consumption of energy and less pollution, knowledge of maritime law and navigation practice, building seaworthiness ships and making studies on the methods of sailing and maneuvering for navigation in polar waters, training qualified seafarers with navigation experiences in ice waters and establishing a safeguard system for the navigation in this route through the analysis on the weather, temperature, ice condition, route and hydrology encountered in the practice of a Chinese merchant ship in its maiden voyage in the route, and studies on the ice pilotage, convoy by icebreaker, practical condition of communication and navigation equipment in sea areas of high latitude and the economic benefit of the navigation in the Arctic Northeast Route.

The planning and comprehensive utilization of Three Gorges Project

As the most significant water project,the Three Gorges Project (TGP) was designed to take care of multiple objectives for water utilization such as flood control,power generation and navigation.The implementation of the project improved the flood safety level of Jingjiang reach to more than 100-year return period,which reduced greatly the flood risk at the mid-lower reaches of Changjiang River,produce huge quantity of energy for the central,east and south China,and improved significantly the navigation conditions of Chuanjiang River.Meanwhile,the operation of the TGP in dry season which compensate the downstream water resources,will as well deepen the navigation channel and thus improve the navigation conditions in the middle river reach.With the increasing demands raised from various aspects of the society,new requirements will be made for the TGP for the purpose of harnessing,development and protection of the Yangtze River Basin.Therefore,it will be a long-term task for the operation of TGP on how to optimize the water resources utilization and implement an effective operation.

A new type of facility to assist ship safely though the Rapids Rubber Dam

Rapids and shoals in the channel have a huge impact on the safety of the ship navigation, Based on the principle of a rubber dam can always adjust the height of the dam and raise upstream water level, This thesis creatively proposed the principle which applied to rapids and shoals in the Channel. In order to achieve the purpose of assisting ship through the channel safely. In this paper, through theoretical calculations verified the rubber dam has characteristics of raising water level, increasing the depth of the shoals, reducing the flow velocity, reducing water surface slope and improving the conditions of navigation. Therefore, this study has a wide range of practical value and application prospects in the project

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