The public’s attitudes can affect the experience of stuttering of people who stutter.This study investigated the attitudes held by the public about people who stutter in China.A web-based written survey with closed a...The public’s attitudes can affect the experience of stuttering of people who stutter.This study investigated the attitudes held by the public about people who stutter in China.A web-based written survey with closed and open-ended questions was implemented to develop a rich understanding.One hundred and two respondents in 26 provinces and 3 municipalities provided comments on people who stutter in their life aspects such as personality,speech,social life,work,life participation,education,dating and marriage,capability,and communication skills.The predominantly negative attitudes towards the overall domains were identified.Attitudes to people who stutter varied according to the different sources of knowledge.Familiarity with people who stutter might reduce stereotypes.However,knowledge from the media might aggravate stereotypes.Implications and future research orientation were also discussed.展开更多
Cardiovascular diseases are a group of disorders of the heart and blood vessels,primarily including coronary heart disease,stroke,and other diseases.It is the world’s leading cause of death,and its incidence is incre...Cardiovascular diseases are a group of disorders of the heart and blood vessels,primarily including coronary heart disease,stroke,and other diseases.It is the world’s leading cause of death,and its incidence is increasing yearly.Hypertension is a major risk factor for cardiovascular disease.Wnt signaling comprises a series of highly conservative cascading events controlling fundamental biological processes.Wnt signaling pathways include the canonical Wnt pathway(or Wnt/β-catenin pathway),the non canonical planar cell-polarity pathway,and the non-canonical calcium-dependent pathways.Abnormal Wnt signaling promotes cell proliferation and differentiation,cardiac malformations,various malignancies,so drugs targeting Wnt signaling play a great therapeutic potential.Wnt/β-catenin pathway is involved in the occurrence and development of cardiovascular diseases such as atherosclerosis and stroke by regulating cell proliferation,migration,apoptosis,blood-brain barrier permeability,inflammation,oxidative stress,and immune response.Based on the latest research progress,this review summarizes the role of Wnt/β-catenin signaling in cardiovascular diseases,in order to provide new ideas for the prevention and treatment of cardiovascular diseases.展开更多
Traffic wave theory is used to study the critical conditions for traffic jams according to their features. First, the characteristics of traffic wave propagation is analyzed for the simple signal-controlled lane and t...Traffic wave theory is used to study the critical conditions for traffic jams according to their features. First, the characteristics of traffic wave propagation is analyzed for the simple signal-controlled lane and the critical conditions for oversaturation is established. Then, the basic road is decomposed into a series of one-way links according to its topological characteristics. Based on the decomposition, traffic wave propagation under complex conditions is studied. Three complicated factors are considered to establish the corresponding critical conditions of jam formation, namely, dynamic and insufficient split, channelized section spillover and endogenous traffic flow. The results show that road geometric features, traffic demand structures and signal settings influence the formation and propagation of traffic congestion. These findings can serve as a theoretical basis for future network jam control.展开更多
To alleviate the resulting increase in energy consumption and emissions and other issues caused by the traffic congestion ahead of the expressway toll station, a novel traffic flowcontrol method is put forward based o...To alleviate the resulting increase in energy consumption and emissions and other issues caused by the traffic congestion ahead of the expressway toll station, a novel traffic flowcontrol method is put forward based on the environment-friendly conception. The technical thinking of inducing the slowly moving traffic into a batch pass is determined based on the conclusion of the research, traffic flowtheory and traffic sensing detection technology. The model of stop times is established and the parameters of the system are optimized in accordance with the principle of minimizing the fuel consumption. The optimal location selection of traffic control lights and Detector 2 for queue of different lengths at toll stations are calculated based on the model. Finally, the effect of the congestion flowcontrol system is verified via the Paramics simulation system. The result shows that the control system is capable of reducing90% of fuel consumption for vehicles going through toll stations.展开更多
The effects of socio-demographics, land use characteristics and trip attributes on the commute mode choice are studied with a nested logit （NL） model. Based on the random utility maximum theory, the NL model is form...The effects of socio-demographics, land use characteristics and trip attributes on the commute mode choice are studied with a nested logit （NL） model. Based on the random utility maximum theory, the NL model is formulated. The analysis is carried out in the main area of Nanjing. Direct and cross elasticities are calculated to analyze the effects of travel time and travel cost on the selection of travel mode choice. The results reveal that the non-motorized travel modes are more attractive in the areas with higher housing and employment accessibility and car owners are found to be more likely to commute to work by car. The bus and subway choice probabilities are more sensitive to changes in travel times than to changes in travel costs. In conclusion, a comprehensive public transit system and effective integration of land use and transportation policies help to relieve the traffic congestion levels caused by the increasing urban sprawl.展开更多
The common phenomenon of uneven headway in bus service is explored based on the automatic vehicle location （AVL） data of Route 2 in Yichun City of Jiangxi province from 6：00 to 9：00 in the morning. The headway reg...The common phenomenon of uneven headway in bus service is explored based on the automatic vehicle location （AVL） data of Route 2 in Yichun City of Jiangxi province from 6：00 to 9：00 in the morning. The headway regularity of two stages 6： 00--7：00 and 7： 00--9：00 is comparatively analyzed, and it is found that both the traffic conditions and the passenger demand affect headway regularity. A bus arrival model, which assumes that the dwell time of a bus is linear in headway, is built to probe the effect of scheduled headway, and the model is simulated by Matlab. The simulation results reveal that the departure intervals and fluctuations affect headway regularity. Longer intervals and less fluctuation mean higher regularity of headway. And, the fluctuation has a more obvious influence on headway regularity than the interval. Controlling the fluctuations of scheduled headway can effectively raise the regularity of headway and improve the level of public transport service.展开更多
A capacity model of multi-phase signalized intersections is derived by a stopping-line method. It is simplified with two normal situations： one situation involves one straight lane and one left-turn lane; the other s...A capacity model of multi-phase signalized intersections is derived by a stopping-line method. It is simplified with two normal situations： one situation involves one straight lane and one left-turn lane; the other situation involves two straight lanes and one left-turn lane. The results show that the capacity is mainly relative to signal cycle length, phase length, intersection layout and following time. With regard to the vehicles arrival rates, the optimal model is derived based on each phase＇s remaining time balance, and it is solved by Lagrange multipliers. Therefore, the calculation models of the optimal signal cycle length and phase lengths are derived and simplified. Compared to the existing models, the proposed model is more convenient and practical. Finally, a practical intersection is chosen and its signal cycles and phase lengths are calculated by the proposed model.展开更多
Vuggy reservoirs are the most common, albeit important heterogeneous carbonate reservoirs in China. However, saturation calculations using logging data are not well developed, whereas Archie method is more common. In ...Vuggy reservoirs are the most common, albeit important heterogeneous carbonate reservoirs in China. However, saturation calculations using logging data are not well developed, whereas Archie method is more common. In this study, electrical conduction in a vuggy reservoir is theoretically analyzed to establish a new saturation equation for vuggy reservoirs. We found that vugs have a greater effect on saturation than resistivity, which causes inflection in the rock-electricity curve. Using single-variable exPeriments, we evaluated the effects of rug size, vug number, and vug distribution on the rock-electricity relation. Based on the general saturation model, a saturation equation for vuggy reservoirs is derived, and the physical significance of the equation parameters is discussed based on the seepage-electricity similarity. The equation parameters depend on the pore structure, and vugs and matrix pore size distribution. Furthermore, a method for calculating the equation parameters is proposed, which uses nuclear magnetic resonance （NMR） data to calculate the capillary pressure curve. Field application of the proposed equation and parameter derivation method shows good match between calculated and experimental results, with an average absolute error of 5.8%.展开更多
In order to describe the travel time of signalcontrolled roads, a travel time model for urban basic roads based on the cumulative curve is proposed. First, the traffic wave method is used to analyze the formation and ...In order to describe the travel time of signalcontrolled roads, a travel time model for urban basic roads based on the cumulative curve is proposed. First, the traffic wave method is used to analyze the formation and dispersion of the vehicle queue. Cumulative curves for road entrances and exits are established. Based on the cumulative curves, the travel time of the one-lane road under stable flow input is derived. And then, the multi-lane road is decomposed into a series of single-lane links based on its topological characteristics. Hence, the travel time function for the basic road is obtained. The travel time is a function of road length, flow and control parameters. Numerical analyses show that the travel time depends on the supply-demand condition, and it has high sensitivity during peak hours.展开更多
To meet the requirements of modeling the new modality of peer-to-peer（P2P）network applications which have been rapidly developing in the Internet recently, a formal description method for modeling multiparty concurr...To meet the requirements of modeling the new modality of peer-to-peer（P2P）network applications which have been rapidly developing in the Internet recently, a formal description method for modeling multiparty concurrent network interactions is studied. The main characteristics and the classifications of P2P systems are discussed. Considering the requirements of P2P application modeling and referring to the component-based modeling thought, a description method based on communicating sequential processes （CSP）is proposed for the P2P network models. By using a CSP process group, this method can describe the dynamic interactive relationship which focuses on multiparty concurrent interaction of P2P systems more advantageously and accurately. The application of nondeterministic semantemes of CSP in describing the interactive relationship of P2P networks is discussed. The advantages and description abilities of the proposed method are demonstrated through the modeling of a new P2P media-on-demand system.展开更多
[ Objective ] The aim of the research was to study the expression profile changes of genes involved in lipid metabolism pathway during liver regeneration in mice. [ Method] The CCI4 induced mouse model of liver regene...[ Objective ] The aim of the research was to study the expression profile changes of genes involved in lipid metabolism pathway during liver regeneration in mice. [ Method] The CCI4 induced mouse model of liver regeneration was established and the total RNA was isolated from liver tissue of mouse. Then the changes of genes involved in lipid metabolism pathway during different stages of liver regeneration were detected through micro-array chip gene technique and their specific functions were also analyzed. [ Result] Dudng the process of liver regeneration, the expression level of 98 genes involved in lipid metabolism pathway changed, which were divided into eight groups according to change trend. In the mass, the expression of genes was inhibited in the early stage and up-regulated in the late phase. And the gene expression associated with fatty acid synthesis pathway was mainly up-regulated while the catabolic pathway did not change significantly. Most of genes involved in bile acid synthesis pathway were suppressed before 4.5 d and up-regulated after 4.5 d or 7 d. [ Conclusion] During the process of liver regeneration, the genes associated with lipid metabolism are expressed in different trends, and this data should provide a specific range of genes for further studying the regulation effect of lipid metabolism related pathway on liver regeneration.展开更多
文摘The public’s attitudes can affect the experience of stuttering of people who stutter.This study investigated the attitudes held by the public about people who stutter in China.A web-based written survey with closed and open-ended questions was implemented to develop a rich understanding.One hundred and two respondents in 26 provinces and 3 municipalities provided comments on people who stutter in their life aspects such as personality,speech,social life,work,life participation,education,dating and marriage,capability,and communication skills.The predominantly negative attitudes towards the overall domains were identified.Attitudes to people who stutter varied according to the different sources of knowledge.Familiarity with people who stutter might reduce stereotypes.However,knowledge from the media might aggravate stereotypes.Implications and future research orientation were also discussed.
文摘Cardiovascular diseases are a group of disorders of the heart and blood vessels,primarily including coronary heart disease,stroke,and other diseases.It is the world’s leading cause of death,and its incidence is increasing yearly.Hypertension is a major risk factor for cardiovascular disease.Wnt signaling comprises a series of highly conservative cascading events controlling fundamental biological processes.Wnt signaling pathways include the canonical Wnt pathway(or Wnt/β-catenin pathway),the non canonical planar cell-polarity pathway,and the non-canonical calcium-dependent pathways.Abnormal Wnt signaling promotes cell proliferation and differentiation,cardiac malformations,various malignancies,so drugs targeting Wnt signaling play a great therapeutic potential.Wnt/β-catenin pathway is involved in the occurrence and development of cardiovascular diseases such as atherosclerosis and stroke by regulating cell proliferation,migration,apoptosis,blood-brain barrier permeability,inflammation,oxidative stress,and immune response.Based on the latest research progress,this review summarizes the role of Wnt/β-catenin signaling in cardiovascular diseases,in order to provide new ideas for the prevention and treatment of cardiovascular diseases.
基金The National Basic Research Program of China(973 Program)(No.2006CB705505)the Basic Scientific Research Fund of Jilin University(No.200903209)
文摘Traffic wave theory is used to study the critical conditions for traffic jams according to their features. First, the characteristics of traffic wave propagation is analyzed for the simple signal-controlled lane and the critical conditions for oversaturation is established. Then, the basic road is decomposed into a series of one-way links according to its topological characteristics. Based on the decomposition, traffic wave propagation under complex conditions is studied. Three complicated factors are considered to establish the corresponding critical conditions of jam formation, namely, dynamic and insufficient split, channelized section spillover and endogenous traffic flow. The results show that road geometric features, traffic demand structures and signal settings influence the formation and propagation of traffic congestion. These findings can serve as a theoretical basis for future network jam control.
基金The Natural Science Foundation of Hebei Province(No.E2013202228)the Science and Technology Planning Project of the Department of Transportation of Hebei Province(No.R070245)
文摘To alleviate the resulting increase in energy consumption and emissions and other issues caused by the traffic congestion ahead of the expressway toll station, a novel traffic flowcontrol method is put forward based on the environment-friendly conception. The technical thinking of inducing the slowly moving traffic into a batch pass is determined based on the conclusion of the research, traffic flowtheory and traffic sensing detection technology. The model of stop times is established and the parameters of the system are optimized in accordance with the principle of minimizing the fuel consumption. The optimal location selection of traffic control lights and Detector 2 for queue of different lengths at toll stations are calculated based on the model. Finally, the effect of the congestion flowcontrol system is verified via the Paramics simulation system. The result shows that the control system is capable of reducing90% of fuel consumption for vehicles going through toll stations.
基金The National Natural Science Foundation of China(No.50908051)
文摘The effects of socio-demographics, land use characteristics and trip attributes on the commute mode choice are studied with a nested logit （NL） model. Based on the random utility maximum theory, the NL model is formulated. The analysis is carried out in the main area of Nanjing. Direct and cross elasticities are calculated to analyze the effects of travel time and travel cost on the selection of travel mode choice. The results reveal that the non-motorized travel modes are more attractive in the areas with higher housing and employment accessibility and car owners are found to be more likely to commute to work by car. The bus and subway choice probabilities are more sensitive to changes in travel times than to changes in travel costs. In conclusion, a comprehensive public transit system and effective integration of land use and transportation policies help to relieve the traffic congestion levels caused by the increasing urban sprawl.
基金The National Basic Research Program of China(973 Program)(No.2012CB725402)the National Natural Science Foundation of China(No.50978057)Program of Scientific Innovation Research of College Graduate in Jiangsu Province(No.CXLX12_0108)
文摘The common phenomenon of uneven headway in bus service is explored based on the automatic vehicle location （AVL） data of Route 2 in Yichun City of Jiangxi province from 6：00 to 9：00 in the morning. The headway regularity of two stages 6： 00--7：00 and 7： 00--9：00 is comparatively analyzed, and it is found that both the traffic conditions and the passenger demand affect headway regularity. A bus arrival model, which assumes that the dwell time of a bus is linear in headway, is built to probe the effect of scheduled headway, and the model is simulated by Matlab. The simulation results reveal that the departure intervals and fluctuations affect headway regularity. Longer intervals and less fluctuation mean higher regularity of headway. And, the fluctuation has a more obvious influence on headway regularity than the interval. Controlling the fluctuations of scheduled headway can effectively raise the regularity of headway and improve the level of public transport service.
基金China Postdoctoral Science Foundation(No.2004035208)Jiangsu Communication Science Foundation (No.06Y36)
文摘A capacity model of multi-phase signalized intersections is derived by a stopping-line method. It is simplified with two normal situations： one situation involves one straight lane and one left-turn lane; the other situation involves two straight lanes and one left-turn lane. The results show that the capacity is mainly relative to signal cycle length, phase length, intersection layout and following time. With regard to the vehicles arrival rates, the optimal model is derived based on each phase＇s remaining time balance, and it is solved by Lagrange multipliers. Therefore, the calculation models of the optimal signal cycle length and phase lengths are derived and simplified. Compared to the existing models, the proposed model is more convenient and practical. Finally, a practical intersection is chosen and its signal cycles and phase lengths are calculated by the proposed model.
基金supported by the National S&T Major Special Project(No.2011ZX05020-008)
文摘Vuggy reservoirs are the most common, albeit important heterogeneous carbonate reservoirs in China. However, saturation calculations using logging data are not well developed, whereas Archie method is more common. In this study, electrical conduction in a vuggy reservoir is theoretically analyzed to establish a new saturation equation for vuggy reservoirs. We found that vugs have a greater effect on saturation than resistivity, which causes inflection in the rock-electricity curve. Using single-variable exPeriments, we evaluated the effects of rug size, vug number, and vug distribution on the rock-electricity relation. Based on the general saturation model, a saturation equation for vuggy reservoirs is derived, and the physical significance of the equation parameters is discussed based on the seepage-electricity similarity. The equation parameters depend on the pore structure, and vugs and matrix pore size distribution. Furthermore, a method for calculating the equation parameters is proposed, which uses nuclear magnetic resonance （NMR） data to calculate the capillary pressure curve. Field application of the proposed equation and parameter derivation method shows good match between calculated and experimental results, with an average absolute error of 5.8%.
基金The National Basic Research Program of China (973 Program) ( No. 2006CB705505)the Basic Scientific Research Fund of Jilin University ( No. 200903209)
文摘In order to describe the travel time of signalcontrolled roads, a travel time model for urban basic roads based on the cumulative curve is proposed. First, the traffic wave method is used to analyze the formation and dispersion of the vehicle queue. Cumulative curves for road entrances and exits are established. Based on the cumulative curves, the travel time of the one-lane road under stable flow input is derived. And then, the multi-lane road is decomposed into a series of single-lane links based on its topological characteristics. Hence, the travel time function for the basic road is obtained. The travel time is a function of road length, flow and control parameters. Numerical analyses show that the travel time depends on the supply-demand condition, and it has high sensitivity during peak hours.
基金The National Basic Research Program of China (973 Program)(No.2003CB314801,2009CB320501)
文摘To meet the requirements of modeling the new modality of peer-to-peer（P2P）network applications which have been rapidly developing in the Internet recently, a formal description method for modeling multiparty concurrent network interactions is studied. The main characteristics and the classifications of P2P systems are discussed. Considering the requirements of P2P application modeling and referring to the component-based modeling thought, a description method based on communicating sequential processes （CSP）is proposed for the P2P network models. By using a CSP process group, this method can describe the dynamic interactive relationship which focuses on multiparty concurrent interaction of P2P systems more advantageously and accurately. The application of nondeterministic semantemes of CSP in describing the interactive relationship of P2P networks is discussed. The advantages and description abilities of the proposed method are demonstrated through the modeling of a new P2P media-on-demand system.
文摘[ Objective ] The aim of the research was to study the expression profile changes of genes involved in lipid metabolism pathway during liver regeneration in mice. [ Method] The CCI4 induced mouse model of liver regeneration was established and the total RNA was isolated from liver tissue of mouse. Then the changes of genes involved in lipid metabolism pathway during different stages of liver regeneration were detected through micro-array chip gene technique and their specific functions were also analyzed. [ Result] Dudng the process of liver regeneration, the expression level of 98 genes involved in lipid metabolism pathway changed, which were divided into eight groups according to change trend. In the mass, the expression of genes was inhibited in the early stage and up-regulated in the late phase. And the gene expression associated with fatty acid synthesis pathway was mainly up-regulated while the catabolic pathway did not change significantly. Most of genes involved in bile acid synthesis pathway were suppressed before 4.5 d and up-regulated after 4.5 d or 7 d. [ Conclusion] During the process of liver regeneration, the genes associated with lipid metabolism are expressed in different trends, and this data should provide a specific range of genes for further studying the regulation effect of lipid metabolism related pathway on liver regeneration.
