Inflammatory bowel diseases(IBD),including ulcerative colitis(UC) and Crohn's disease(CD),are chronic,progressive and disabling disorders.Over the last few decades,new therapeutic approaches have been introduced w...Inflammatory bowel diseases(IBD),including ulcerative colitis(UC) and Crohn's disease(CD),are chronic,progressive and disabling disorders.Over the last few decades,new therapeutic approaches have been introduced which have led not only to a reduction in the mortality rate but also offered the possibility of a favorable modification in the natural history of IBD.The identification of clinical,genetic and serological prognostic factors has permitted a better stratification of the disease,thus allowing the opportunity to indicate the most appropriate therapy.Early treatment with immunosuppressive drugs and biologics has offered the opportunity to change,at least in the short term,the course of the disease by reducing,in a subset of patients with IBD,hospitalization and the need for surgery.In this review,the crucial steps in the natural history of both UC and CD will be discussed,as well as the factors that may change their clinical course.The methodological requirements for high quality studies on the course and prognosis of IBD,the true impact of environmental and dietary factors on the clinical course of IBD,the clinical,serological and genetic predictors of the IBD course(in particular,which of these are rel-evant and appropriate for use in clinical practice),the impact of the various forms of medical treatment on the IBD complication rate,the role of surgery for IBD in the biologic era,the true magnitude of risk of colorectal cancer associated with IBD,as well as the mortality rate related to IBD will be stressed;all topics that are extensively discussed in separate reviews included in this issue of World Journal of Gastroenterology.展开更多
The structure and stability of the compounds MRg^(+)and MRg F(Rg=Ar,Kr,and Xe;M=Co,Rh,and Ir)were investigated using the B3 LYP,MP2,MP4(SDQ)and CCSD(T)methods.We reported the geometry,vibrational frequencies and therm...The structure and stability of the compounds MRg^(+)and MRg F(Rg=Ar,Kr,and Xe;M=Co,Rh,and Ir)were investigated using the B3 LYP,MP2,MP4(SDQ)and CCSD(T)methods.We reported the geometry,vibrational frequencies and thermodynamics properties of these compounds.A series of theoretical methods on the basis of wavefunction analysis,including natural bond orbitals,atoms in molecules,electron localization function,and energy decomposition analysis,were performed to explore bonding nature of the M-Rg and Rg-F bonds.These bonds are mainly noncovalent,the metal weakly interacts with Rg in MRg^(+),but their interaction is much stronger in MRg F.The neutral molecule MRg F can be well described by the Lewis structure[MRg]^(+)F^(-).展开更多
Village is an important implementation unit of national poverty alleviation and development strategies of rural China, and identifying the poverty degree, poverty type and poverty contributing factors of each poverty-...Village is an important implementation unit of national poverty alleviation and development strategies of rural China, and identifying the poverty degree, poverty type and poverty contributing factors of each poverty-stricken village is the precondition and guarantee of taking targeted measures in poverty alleviation strategies of China. To respond it, we construct a village-level multidimensional poverty measuring model, and use indicator contribution degree indices and linear regression method to explore poverty factors, while adopting Least Square Error(LSE) model and spatial econometric analysis model to identify the villages' poverty types and poverty difference. The case study shows that:(1) Spatially, there is obvious territoriality in the distribution of poverty-stricken villages, and the poverty-stricken villages are concentrated in contiguous poverty-stricken areas. The areas with the highest VPI, in a descending order, are Gansu, Yunnan, Guizhou, Guangxi, Hunan, Qinghai, Sichuan, and Xinjiang.(2) The main factors contributing to the poverty of poverty-stricken villages in rural China include road construction, terrain type, frequency of natural disasters, per capita net income, labor force ratio, and cultural quality of labor force. The main causes of poverty include underdeveloped road construction conditions, frequent natural disasters, low level of income, and labor conditions.(3) Chinese poverty-stricken villages include six main subtypes, and most poverty-stricken villages are affected by multiple poverty-forming factors, reflected by a relatively high proportion of the three-factor dominant type, four-factor coordinative type, and five-factor combinative type.(4) There exist significant poverty differences in terms of geographical location and policy support, and the governments still need to carry out targeted poverty alleviation measures according to local conditions. The research can not only draw a macro overall poverty-reduction outline of impoverished villages in China, but also depict the specific poverty characteristics of each village, helping the government departments of pov-erty alleviation at all levels to mobilize all kinds of anti-poverty resources.展开更多
文摘Inflammatory bowel diseases(IBD),including ulcerative colitis(UC) and Crohn's disease(CD),are chronic,progressive and disabling disorders.Over the last few decades,new therapeutic approaches have been introduced which have led not only to a reduction in the mortality rate but also offered the possibility of a favorable modification in the natural history of IBD.The identification of clinical,genetic and serological prognostic factors has permitted a better stratification of the disease,thus allowing the opportunity to indicate the most appropriate therapy.Early treatment with immunosuppressive drugs and biologics has offered the opportunity to change,at least in the short term,the course of the disease by reducing,in a subset of patients with IBD,hospitalization and the need for surgery.In this review,the crucial steps in the natural history of both UC and CD will be discussed,as well as the factors that may change their clinical course.The methodological requirements for high quality studies on the course and prognosis of IBD,the true impact of environmental and dietary factors on the clinical course of IBD,the clinical,serological and genetic predictors of the IBD course(in particular,which of these are rel-evant and appropriate for use in clinical practice),the impact of the various forms of medical treatment on the IBD complication rate,the role of surgery for IBD in the biologic era,the true magnitude of risk of colorectal cancer associated with IBD,as well as the mortality rate related to IBD will be stressed;all topics that are extensively discussed in separate reviews included in this issue of World Journal of Gastroenterology.
文摘The structure and stability of the compounds MRg^(+)and MRg F(Rg=Ar,Kr,and Xe;M=Co,Rh,and Ir)were investigated using the B3 LYP,MP2,MP4(SDQ)and CCSD(T)methods.We reported the geometry,vibrational frequencies and thermodynamics properties of these compounds.A series of theoretical methods on the basis of wavefunction analysis,including natural bond orbitals,atoms in molecules,electron localization function,and energy decomposition analysis,were performed to explore bonding nature of the M-Rg and Rg-F bonds.These bonds are mainly noncovalent,the metal weakly interacts with Rg in MRg^(+),but their interaction is much stronger in MRg F.The neutral molecule MRg F can be well described by the Lewis structure[MRg]^(+)F^(-).
基金National Natural Science Foundation of China,No.41771157National Key Research and Development Program of China,No.2018YFB0505402+1 种基金Scientific Research Project of Beijing Education Committee,No.KM201810028014Capacity Building for Sci-Tech Innovation-Fundamental Scientific Research Funds,No.025185305000/192
文摘Village is an important implementation unit of national poverty alleviation and development strategies of rural China, and identifying the poverty degree, poverty type and poverty contributing factors of each poverty-stricken village is the precondition and guarantee of taking targeted measures in poverty alleviation strategies of China. To respond it, we construct a village-level multidimensional poverty measuring model, and use indicator contribution degree indices and linear regression method to explore poverty factors, while adopting Least Square Error(LSE) model and spatial econometric analysis model to identify the villages' poverty types and poverty difference. The case study shows that:(1) Spatially, there is obvious territoriality in the distribution of poverty-stricken villages, and the poverty-stricken villages are concentrated in contiguous poverty-stricken areas. The areas with the highest VPI, in a descending order, are Gansu, Yunnan, Guizhou, Guangxi, Hunan, Qinghai, Sichuan, and Xinjiang.(2) The main factors contributing to the poverty of poverty-stricken villages in rural China include road construction, terrain type, frequency of natural disasters, per capita net income, labor force ratio, and cultural quality of labor force. The main causes of poverty include underdeveloped road construction conditions, frequent natural disasters, low level of income, and labor conditions.(3) Chinese poverty-stricken villages include six main subtypes, and most poverty-stricken villages are affected by multiple poverty-forming factors, reflected by a relatively high proportion of the three-factor dominant type, four-factor coordinative type, and five-factor combinative type.(4) There exist significant poverty differences in terms of geographical location and policy support, and the governments still need to carry out targeted poverty alleviation measures according to local conditions. The research can not only draw a macro overall poverty-reduction outline of impoverished villages in China, but also depict the specific poverty characteristics of each village, helping the government departments of pov-erty alleviation at all levels to mobilize all kinds of anti-poverty resources.
