This study aimed to evaluate the safety of Manhuning oral liquid and to provide safety basis for clinical treatment. A total of 120 chickens of 14 days old were selected. After one week of adaptive feeding, they were ...This study aimed to evaluate the safety of Manhuning oral liquid and to provide safety basis for clinical treatment. A total of 120 chickens of 14 days old were selected. After one week of adaptive feeding, they were evenly and randomly divided into four groups： one time the therapeutic dose （T1）, three times the therapeutic dose （T2）, five times the therapeutic dose （T3） and control （CK）. In different groups, the chickens were fed with Manhuning oral liquid according to the set doses for one week. At the beginning and at the end of the experiment, total 10 chickens were selected randomly from each group, respectively. They were weighed, and their blood was sampled for determination of routine blood indexes and examination of liver and kidney function. Organ indexes were determined, and pathological examination was conducted for the head, liver, spleen, lung and kidney of the chickens. The results showed that the body mass gain and organ indexes differed insignificantly among different groups （P〉0.05）. No significant differences were found in the routine blood indexes, serum ALT activity, albumin content, creatinine content and urea content among different groups before and after the experiment （P〉0.05）. After the administration, the head, liver, spleen, lung and kidney of the chickens showed no obvious abnormalities. In shod, Manhuning oral liquid had little impact on the physiological and biochemical indexes and had no toxic effects on the head, liver, spleen, lung and kidney of chickens, and it is a low-toxicity safe veterinary drug preparation.展开更多
AIM: To investigate the effect of carbachol on gastrointestinal function in a dog model of oral resuscitation for burn shock. METHODS: Twenty Beagle dogs with intubation of the carotid artery, jugular vein and jejunum...AIM: To investigate the effect of carbachol on gastrointestinal function in a dog model of oral resuscitation for burn shock. METHODS: Twenty Beagle dogs with intubation of the carotid artery, jugular vein and jejunum for 24 h were subjected to 35% total body surface area fullthickness burns, and were divided into three groups: no fluid resuscitation (NR, n = 10), in which animals did not receive fluid by any means in the first 24 h postburn; oral fluid resuscitation (OR, n = 8), in which dogs were gavaged with glucose-electrolyte solution (GES) with volume and rate consistent with the Parkland formula; and oral fluid with carbachol group (OR/CAR, n = 8), in which dogs were gavaged with GES containing carbachol (20 μg/kg), with the same volume and rate as the OR group. Twenty-four hours after burns, all animals were given intravenous fluid replacement, and 72 h after injury, they received nutritional support. Hemodynamicand gastrointestinal parameters were measured serially with animals in conscious and cooperative state. RESULTS: The mean arterial pressure, cardiac output and plasma volume dropped markedly, and gastrointestinal tissue perfusion was reduced obviously after the burn injury in all the three groups. Hemodynamic parameters and gastrointestinal tissue perfusion in the OR and OR/CAR groups were promoted to pre-injury level at 48 and 72 h, respectively, while hemodynamic parameters in the NR group did not return to pre-injury level till 72 h, and gastrointestinal tissue perfusion remained lower than pre-injury level until 120 h post-burn. CO 2 of the gastric mucosa and intestinal mucosa blood flow of OR/CAR groups were 56.4 ± 4.7 mmHg and 157.7 ± 17.7 blood perfusion units (BPU) at 24 h postburn, respectively, which were significantly superior to those in the OR group (65.8 ± 5.8 mmHg and 127.7 ± 11.9 BPU, respectively, all P < 0.05). Gastric emptying and intestinal absorption rates of GES were significantly reduced to the lowest level (52.8% and 23.7% of pre-injury levels) in the OR group at about 2 and 4 h post-burn, and did not return to 80% of pre-injury level until 24 h. In the first 24 h postburn, the rate of gastric emptying and intestinal water absorption were elevated by a mean 15.7% and 11.5%, respectively, in the OR/CAR group compared with the OR group. At 5 days, the mortality in the NR group was 30% (3/10), 12.5% in the OR group (1/8), and none in the OR/CAR group. CONCLUSION: Carbachol had a beneficial effect on oral resuscitation of burn shock by promoting gastric emptying and intestinal absorption in our canine model.展开更多
AIM:To report our experience using a recently introduced anchoring balloon for diagnostic and therapeutic direct peroral cholangioscopy(DPOC).METHODS:Consecutive patients referred for diagnostic or therapeutic peroral...AIM:To report our experience using a recently introduced anchoring balloon for diagnostic and therapeutic direct peroral cholangioscopy(DPOC).METHODS:Consecutive patients referred for diagnostic or therapeutic peroral cholangioscopy were evaluated in a prospective cohort study.The patients underwent DPOC using an intraductal anchoring balloon,which was recently introduced to allow consistent access to the biliary tree with an ultraslim upper endoscope.The device was later voluntarily withdrawn from the market by the manufacturer.RESULTS:Fourteen patients underwent DPOC using the anchoring balloon.Biliary access with an ultraslim upper endoscope was accomplished in all 14 patients.In 12(86%) patients,ductal access required sphincteroplasty with a 10-mm dilating balloon.Intraductal placement of the ultraslim upper endoscope allowed satisfactory visualization of the biliary mucosa to the level of the confluence of the right and left hepatic ducts in 13 of 14 patients(93%).Therapeutic interventions by DPOC were successfully completed in all five attempted cases(intraductal biopsy in one and DPOC guided laser lithotripsy in four).Adverse events occurred in a patient on immunosuppressive therapy who developed an intrahepatic biloma at the site of the anchoring balloon.This required hospitalization and antibiotics.Repeat endoscopic retrograde cholangiopancreatography 8 wk after the index procedure showed resolution of the biloma.CONCLUSION:Use of this anchoring balloon allowed consistent access to the biliary tree for performance of diagnostic and therapeutic DPOC distal to the biliary bifurcation.展开更多
The goal of this paper is to present the ethical issues that are relevant at the concept development stage and inspiring its development during the CONFIDENCE （Ubiquitous Care System to Support Independent Living） p...The goal of this paper is to present the ethical issues that are relevant at the concept development stage and inspiring its development during the CONFIDENCE （Ubiquitous Care System to Support Independent Living） project. We propose that the technology must support principles such as human rights, privacy, safety, and dignity. The voluntary contribution of people as participants in research must undergo the scrutiny of research plans by ethical review boards. Informed consent processes and procedures must be observed in this realm. Ethical issues arising in heterogeneous fields involving technology, end-users, service providers, and formal and informal caregivers pose important challenges. Attempting to maximize the ethical compliance of the results of this ICT （information and communication technology） project, we explore and suggest preventive measures for possible scenarios of misuse of this or related technology. Concluding, the observation of ethical principles throughout the development process can empower users to make informed decisions on the acceptance of ICT systems and services when these reach the market.展开更多
This paper addresses the power con- trol problems of Cognitive Radio （CR） trader transmission power and interference tempera- ture constraints. First, we propose the interfer- ence constraint which ensures that the ...This paper addresses the power con- trol problems of Cognitive Radio （CR） trader transmission power and interference tempera- ture constraints. First, we propose the interfer- ence constraint which ensures that the Quality of Service （QoS） standards for primary users is considered and a non-cooperative game power control model. Based on the proposed model, we developed a logical utility function based on the Signal-to-Interference-Noise Ratio （S/NR） and a novel algorithm network power control. that is suitable for CR Then, the existence and uniqueness of the Nash Equilibrium （NE） in our utility function are proved by the principle of game theory and the corresponding optimi- zations. Compared to traditional algorithms, the proposed one could converge to an NE in 3-5 iterative operations by setting an appropriate pricing factor. Finally, simulation results ver- ified the stability and superiority of the novel algorithm in flat-fading channel environments.展开更多
文摘This study aimed to evaluate the safety of Manhuning oral liquid and to provide safety basis for clinical treatment. A total of 120 chickens of 14 days old were selected. After one week of adaptive feeding, they were evenly and randomly divided into four groups： one time the therapeutic dose （T1）, three times the therapeutic dose （T2）, five times the therapeutic dose （T3） and control （CK）. In different groups, the chickens were fed with Manhuning oral liquid according to the set doses for one week. At the beginning and at the end of the experiment, total 10 chickens were selected randomly from each group, respectively. They were weighed, and their blood was sampled for determination of routine blood indexes and examination of liver and kidney function. Organ indexes were determined, and pathological examination was conducted for the head, liver, spleen, lung and kidney of the chickens. The results showed that the body mass gain and organ indexes differed insignificantly among different groups （P〉0.05）. No significant differences were found in the routine blood indexes, serum ALT activity, albumin content, creatinine content and urea content among different groups before and after the experiment （P〉0.05）. After the administration, the head, liver, spleen, lung and kidney of the chickens showed no obvious abnormalities. In shod, Manhuning oral liquid had little impact on the physiological and biochemical indexes and had no toxic effects on the head, liver, spleen, lung and kidney of chickens, and it is a low-toxicity safe veterinary drug preparation.
基金Supported by The Special Foundation of the 11th five-yearPlan for Military Medical Projects, No. 06Z055
文摘AIM: To investigate the effect of carbachol on gastrointestinal function in a dog model of oral resuscitation for burn shock. METHODS: Twenty Beagle dogs with intubation of the carotid artery, jugular vein and jejunum for 24 h were subjected to 35% total body surface area fullthickness burns, and were divided into three groups: no fluid resuscitation (NR, n = 10), in which animals did not receive fluid by any means in the first 24 h postburn; oral fluid resuscitation (OR, n = 8), in which dogs were gavaged with glucose-electrolyte solution (GES) with volume and rate consistent with the Parkland formula; and oral fluid with carbachol group (OR/CAR, n = 8), in which dogs were gavaged with GES containing carbachol (20 μg/kg), with the same volume and rate as the OR group. Twenty-four hours after burns, all animals were given intravenous fluid replacement, and 72 h after injury, they received nutritional support. Hemodynamicand gastrointestinal parameters were measured serially with animals in conscious and cooperative state. RESULTS: The mean arterial pressure, cardiac output and plasma volume dropped markedly, and gastrointestinal tissue perfusion was reduced obviously after the burn injury in all the three groups. Hemodynamic parameters and gastrointestinal tissue perfusion in the OR and OR/CAR groups were promoted to pre-injury level at 48 and 72 h, respectively, while hemodynamic parameters in the NR group did not return to pre-injury level till 72 h, and gastrointestinal tissue perfusion remained lower than pre-injury level until 120 h post-burn. CO 2 of the gastric mucosa and intestinal mucosa blood flow of OR/CAR groups were 56.4 ± 4.7 mmHg and 157.7 ± 17.7 blood perfusion units (BPU) at 24 h postburn, respectively, which were significantly superior to those in the OR group (65.8 ± 5.8 mmHg and 127.7 ± 11.9 BPU, respectively, all P < 0.05). Gastric emptying and intestinal absorption rates of GES were significantly reduced to the lowest level (52.8% and 23.7% of pre-injury levels) in the OR group at about 2 and 4 h post-burn, and did not return to 80% of pre-injury level until 24 h. In the first 24 h postburn, the rate of gastric emptying and intestinal water absorption were elevated by a mean 15.7% and 11.5%, respectively, in the OR/CAR group compared with the OR group. At 5 days, the mortality in the NR group was 30% (3/10), 12.5% in the OR group (1/8), and none in the OR/CAR group. CONCLUSION: Carbachol had a beneficial effect on oral resuscitation of burn shock by promoting gastric emptying and intestinal absorption in our canine model.
文摘AIM:To report our experience using a recently introduced anchoring balloon for diagnostic and therapeutic direct peroral cholangioscopy(DPOC).METHODS:Consecutive patients referred for diagnostic or therapeutic peroral cholangioscopy were evaluated in a prospective cohort study.The patients underwent DPOC using an intraductal anchoring balloon,which was recently introduced to allow consistent access to the biliary tree with an ultraslim upper endoscope.The device was later voluntarily withdrawn from the market by the manufacturer.RESULTS:Fourteen patients underwent DPOC using the anchoring balloon.Biliary access with an ultraslim upper endoscope was accomplished in all 14 patients.In 12(86%) patients,ductal access required sphincteroplasty with a 10-mm dilating balloon.Intraductal placement of the ultraslim upper endoscope allowed satisfactory visualization of the biliary mucosa to the level of the confluence of the right and left hepatic ducts in 13 of 14 patients(93%).Therapeutic interventions by DPOC were successfully completed in all five attempted cases(intraductal biopsy in one and DPOC guided laser lithotripsy in four).Adverse events occurred in a patient on immunosuppressive therapy who developed an intrahepatic biloma at the site of the anchoring balloon.This required hospitalization and antibiotics.Repeat endoscopic retrograde cholangiopancreatography 8 wk after the index procedure showed resolution of the biloma.CONCLUSION:Use of this anchoring balloon allowed consistent access to the biliary tree for performance of diagnostic and therapeutic DPOC distal to the biliary bifurcation.
文摘The goal of this paper is to present the ethical issues that are relevant at the concept development stage and inspiring its development during the CONFIDENCE （Ubiquitous Care System to Support Independent Living） project. We propose that the technology must support principles such as human rights, privacy, safety, and dignity. The voluntary contribution of people as participants in research must undergo the scrutiny of research plans by ethical review boards. Informed consent processes and procedures must be observed in this realm. Ethical issues arising in heterogeneous fields involving technology, end-users, service providers, and formal and informal caregivers pose important challenges. Attempting to maximize the ethical compliance of the results of this ICT （information and communication technology） project, we explore and suggest preventive measures for possible scenarios of misuse of this or related technology. Concluding, the observation of ethical principles throughout the development process can empower users to make informed decisions on the acceptance of ICT systems and services when these reach the market.
基金partially supported by the National Natural Science Foundation of China under Grant No.61172073the Open Research Fund of National Mobile Communications Research Laboratory,Southeast University under Grant No.2012D19+1 种基金the Fundamental Research Funds for the Central Universities,Beijing Jiaotong University under Grant No.2013JBZ01the Program for New Century Excellent Talents in University of Ministry of Education of China under Grant No.NCET-12-0766
文摘This paper addresses the power con- trol problems of Cognitive Radio （CR） trader transmission power and interference tempera- ture constraints. First, we propose the interfer- ence constraint which ensures that the Quality of Service （QoS） standards for primary users is considered and a non-cooperative game power control model. Based on the proposed model, we developed a logical utility function based on the Signal-to-Interference-Noise Ratio （S/NR） and a novel algorithm network power control. that is suitable for CR Then, the existence and uniqueness of the Nash Equilibrium （NE） in our utility function are proved by the principle of game theory and the corresponding optimi- zations. Compared to traditional algorithms, the proposed one could converge to an NE in 3-5 iterative operations by setting an appropriate pricing factor. Finally, simulation results ver- ified the stability and superiority of the novel algorithm in flat-fading channel environments.
