Since Caenorhabditis elegans was chosen as a model organism by Sydney Brenner in 1960's, genetic studies in this organism have been instrumental in discovering the function of genes and in deciphering molecular si...Since Caenorhabditis elegans was chosen as a model organism by Sydney Brenner in 1960's, genetic studies in this organism have been instrumental in discovering the function of genes and in deciphering molecular signaling network. The small size of the organism and the simple nervous system enable the complete reconstruction of the first connectome. The stereotypic developmental program and the anatomical reproducibility of synaptic connections provide a blueprint to dissect the mechanisms underlying synapse formation. Recent technological innovation using laser surgery of single axons and in vivo imaging has also made C. elegans a new model for axon regeneration. Importantly, genes regulating synaptogenesis and axon regeneration are highly conserved in function across animal phyla. This mini-review will summarize the main approaches and the key findings in understanding the mechanisms underlying the development and maintenance of the nervous system. The impact of such findings underscores the awesome power of C. elegans genetics.展开更多
In this paper, we provide a framework of fuzzy landscape theory and discuss an application to alliance analysis. The fuzzy landscape theory may allow us to analyses a variety of aggregation processes in political, eco...In this paper, we provide a framework of fuzzy landscape theory and discuss an application to alliance analysis. The fuzzy landscape theory may allow us to analyses a variety of aggregation processes in political, economic, and social problems in a more flexible manner. The simulation results for the problems of the international alignment of the Second World War in Europe and the coalition formation in standard-setting alliances in the case of the UNIX operating system are compared with those given by the original theory.展开更多
基金support from the National Institute of Healththe Howard Hughes Medical Institute of the United States of America
文摘Since Caenorhabditis elegans was chosen as a model organism by Sydney Brenner in 1960's, genetic studies in this organism have been instrumental in discovering the function of genes and in deciphering molecular signaling network. The small size of the organism and the simple nervous system enable the complete reconstruction of the first connectome. The stereotypic developmental program and the anatomical reproducibility of synaptic connections provide a blueprint to dissect the mechanisms underlying synapse formation. Recent technological innovation using laser surgery of single axons and in vivo imaging has also made C. elegans a new model for axon regeneration. Importantly, genes regulating synaptogenesis and axon regeneration are highly conserved in function across animal phyla. This mini-review will summarize the main approaches and the key findings in understanding the mechanisms underlying the development and maintenance of the nervous system. The impact of such findings underscores the awesome power of C. elegans genetics.
基金This research is supported by CAS,NSFC and the National Basic Research Programme in Natural Sciences of Vietnam.
文摘In this paper, we provide a framework of fuzzy landscape theory and discuss an application to alliance analysis. The fuzzy landscape theory may allow us to analyses a variety of aggregation processes in political, economic, and social problems in a more flexible manner. The simulation results for the problems of the international alignment of the Second World War in Europe and the coalition formation in standard-setting alliances in the case of the UNIX operating system are compared with those given by the original theory.
